Lifetime Stressor Severity and Diurnal Cortisol in Older African American Adults: A Comparison of Three Theoretical Models
Developmental Psychobiology,
Journal Year:
2025,
Volume and Issue:
67(2)
Published: March 1, 2025
ABSTRACT
Multiple
theoretical
models
have
been
proposed
to
explain
how
stressor
exposure
across
the
life
course
relates
functioning
of
hypothalamic‐pituitary‐adrenal
(HPA)
axis,
as
indexed
by
daily
cortisol
secretion.
However,
this
association
remains
understudied
in
African
Americans.
The
present
study
tested
three
competing
severity
lifespan
and
diurnal
secretion
a
sample
203
older
American
adults.
cumulative
model
emphasizes
total
lifespan,
biological
embedding
early‐life
severity,
sensitization
instead
interaction
between
recent
severity.
Lifetime
was
assessed
using
Stress
Adversity
Inventory
for
Adults
(Adult
STRAIN).
Analyses
did
not
support
any
but,
rather,
characteristics
perspective,
wherein
specific
associated
with
blunted
slopes.
Sensitivity
analyses
revealed
that
early
count,
rather
than
Rather
supporting
one
our
findings
provide
preliminary
evidence
approach
when
examining
lifetime
affects
HPA‐axis
activity.
Language: Английский
Religious stress coping is associated with lower entorhinal tau pathology and better memory performance in autosomal dominant Alzheimer's disease
Journal of Alzheimer s Disease,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
Stress
is
a
known
risk
factor
for
Alzheimer's
disease
(AD),
but
religious
stress
coping
practices,
(e.g.,
prayer
and
attending
services)
may
reduce
this
risk.
We
investigated
the
relation
between
memory
in
cognitively-unimpaired
individuals
from
Colombian
kindred
with
autosomal
dominant
AD.
Additionally,
we
examined
link
brain
pathology.
Religious
was
associated
lower
entorhinal
tau
(
p
=
0.02)
better
performance
0.04)
Presenilin-1
E280A
mutation
carriers,
not
non-carriers.
These
findings
suggest
that
mitigate
AD
pathology
cognitive
decline
warrant
further
investigation.
Language: Английский
The prevalence of lifetime trauma and association with physical and psychosocial health among adults at the end of life
Journal of the American Geriatrics Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
Abstract
Background
National
guidelines
recognize
lifetime
trauma
as
relevant
to
clinical
care
for
adults
nearing
the
end
of
life.
We
determined
prevalence
early
life
and
cumulative
among
persons
at
by
gender
birth
cohort,
association
with
end‐of‐life
physical,
mental,
social
well‐being.
Methods
used
nationally
representative
Health
Retirement
Study
data
(2006–2020),
including
age
>
50
who
died
while
enrolled
(
N
=
6495).
Early
traumatic
events
were
measured
using
an
11‐item
scale
(cumulative
trauma:
0–5+
over
lifespan).
included
six
cohorts
(born
<1924;
children
depression
[1924–1930];
HRS
cohort
[1931–1941];
war
babies
[1942–1947];
baby‐boomers
[1948–1953];
mid‐baby
boomers
[1954–1959]).
End‐of‐life
outcomes
validated
measures
physical
(pain,
fatigue,
dyspnea),
mental
(depression,
satisfaction),
(loneliness,
isolation)
needs.
report
adjusted
probability
each
outcome
multivariable
logistic
regression.
Results
The
mean
death
was
78
years
(SD
11.1)
52%
female.
Lifetime
common
(0
events:
19%;
1–2:
47%;
3–4:
25%;
5+:
9%),
variation
in
individual
(e.g.,
a
child,
weapons
combat)
cohort.
After
adjustment,
increasing
significantly
associated
p
‐value<0.001)
higher
reports
moderate‐to‐severe
pain
46%;
1–2
50%;
3–4
57%;
5+
60%),
fatigue
(58%;
60%;
66%;
69%),
dyspnea
(46%;
51%;
56%;
58%),
(24%;
33%;
37%;
40%),
loneliness
(12%;
17%;
22%),
lower
satisfaction
(73%;
63%;
58%;
54%).
Conclusion
Older
last
high
which
are
worse
psychosocial
health.
A
trauma‐informed
approach
management
needs
may
improve
patient's
quality
Language: Английский