Pharmacological Research, Journal Year: 2022, Volume and Issue: 186, P. 106535 - 106535
Published: Nov. 2, 2022
Language: Английский
Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106553 - 106553
Published: Nov. 16, 2022
Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response
Language: Английский
Citations
83
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 712 - 712
Published: Feb. 20, 2023
Due to rising incidence rates of liver cancer and worries about the toxicity current chemotherapeutic medicines, hunt for further alternative methods treat this malignancy has escalated. Compared chemotherapy, quercetin, a flavonoid, is relatively less harmful normal cells regarded as an excellent free-radical scavenger. Apoptotic cell death caused by quercetin been demonstrated many prior studies. It present in fruits, vegetables, herbs. Quercetin targets apoptosis, upregulating Bax, caspase-3, p21 while downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2. Additionally, it reported increase STAT3 protein degradation decreasing activation. potential future chemoprevention, based on substantial research its anticancer effects. The review discusses quercetin’s mechanisms action, nanodelivery strategies, other cellular effects cancer.
Language: Английский
Citations
69
Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 245, P. 154442 - 154442
Published: April 6, 2023
Language: Английский
Citations
50
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: Sept. 8, 2023
Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth, and early metastasis. The clinical outcomes of LC patients are generally poor due to the insufficient elucidation pathological mechanisms, low efficiency detection assessment methods, lack individualized therapeutic strategies. Non-coding RNAs (ncRNAs), including microRNA (miRNA), long non-coding RNA (lncRNA), circular (circRNA), endogenous regulators that widely involved in modulation almost all aspects life activities, from organogenesis aging immunity cancer. They commonly play vital roles various biological processes by regulating gene expression via their interactions DNA, RNA, or protein. An increasing amount studies have demonstrated ncRNAs closely correlated initiation development LC. Their dysregulation promotes progression distinct such as influencing protein activity, activating oncogenic signaling pathways, altering specific expression. Furthermore, some present certain values biomarker candidates targets for patients. A complete understanding mechanisms may be highly beneficial developing ncRNA-based therapeutics This review mainly focuses on intricate miRNA, lncRNA, circRNA discuss underlying applications treatment.
Language: Английский
Citations
44
Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27184 - e27184
Published: Feb. 28, 2024
Endoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment HSPA5 from pan-cancer perspective using multi-omics data. We analyzed function in multiple tumor types databases. Finally, immunohistochemistry was used examine relationship between expression tissue microarrays 100 patients with bladder cancer prognosis cancer. Using TCGA database, we were able determine that is significantly elevated number common malignancies linked bad prognosis. Cox regression analysis showed high correlated OS, progression free survival (PFS), disease (DFS), special (DSS) adrenocortical carcinoma (ACC). In addition, discovered significant disparities methylation phosphorylation levels various normal tissues. infiltrating cells immune checkpoint genes. highly expressed have poor Our basis for further understanding role ER gene different genesis development. has also been shown be prognostic biomarker patients.
Language: Английский
Citations
19
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116685 - 116685
Published: May 5, 2024
Colorectal cancer (CRC), with its significant incidence and metastatic rates, profoundly affects human health. A common oncogenic event in CRC is the aberrant activation of Wnt/β-catenin signalling pathway, which drives both initiation progression disease. Persistent facilitates epithelial-mesenchymal transition (EMT), accelerates invasion metastasis. This review provides a summary recent molecular studies on role axis regulating EMT cells, triggers pathogenesis. We present comprehensive examination process transcriptional controllers, an emphasis crucial functions β-catenin, transcription factors (EMT-TFs). also evidences showing that hyperactive phenotypes via "Destruction complex" β-catenin mechanisms. Potential therapeutic challenges approache to suppress prevent cells metastasis by targeting are discussed. These include direct inhibitors novel targets Wnt finally highlight potential combinational treatment options based inhibition pathway.
Language: Английский
Citations
19
Science Bulletin, Journal Year: 2024, Volume and Issue: 69(11), P. 1776 - 1797
Published: March 29, 2024
Undruggable targets typically refer to a class of therapeutic that are difficult target through conventional methods or have not yet been targeted, but great clinical significance. According statistics, over 80% disease-related pathogenic proteins cannot be targeted by current treatment methods. In recent years, with the advancement basic research and new technologies, development various technologies mechanisms has brought perspectives overcome challenging drug targets. Among them, protein degradation technology is breakthrough strategy for This can specifically identify directly degrade utilizing inherent pathways within cells. form includes types such as proteolysis targeting chimera (PROTAC), molecular glue, lysosome-targeting Chimaera (LYTAC), autophagosome-tethering compound (ATTEC), autophagy-targeting (AUTAC), (AUTOTAC), degrader-antibody conjugate (DAC). article systematically summarizes application in degraders Finally, looks forward future direction prospects technology.
Language: Английский
Citations
18
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: July 4, 2024
Abstract Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells, characterized by osteolytic bone lesions, anemia, hypercalcemia, renal failure, and accumulation malignant cells. The pathogenesis MM involves interaction between cells marrow microenvironment through soluble cytokines cell adhesion molecules, which activate various signaling pathways such as PI3K/AKT/mTOR, RAS/MAPK, JAK/STAT, Wnt/β-catenin, NF-κB pathways. Aberrant activation these contributes to proliferation, survival, migration, drug resistance making them attractive targets for therapeutic intervention. Currently, approved drugs targeting in are limited, with many inhibitors inducers still preclinical or clinical research stages. Therapeutic options include non-targeted like alkylating agents, corticosteroids, immunomodulatory drugs, proteasome inhibitors, histone deacetylase inhibitors. Additionally, targeted monoclonal antibodies, chimeric antigen receptor T bispecific T-cell engagers, antibodies being used treatment. Despite significant advancements treatment, disease remains incurable, emphasizing need development novel combined therapies based on emerging theoretical knowledge, technologies, platforms. In this review, we highlight key role progression treatment MM, exploring advances therapy potential treatments offer further insights improving management outcomes.
Language: Английский
Citations
18
Archives of Toxicology, Journal Year: 2022, Volume and Issue: 97(1), P. 103 - 120
Published: Nov. 28, 2022
Language: Английский
Citations
56
Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1185 - 1185
Published: Aug. 26, 2022
There have been magnificent advancements in the understanding of molecular mechanisms chronic diseases over past several years, but these continue to be a considerable cause death worldwide. Most approved medications available for prevention and treatment target only single gene/protein/pathway are known severe side effects less effective than they anticipated. Consequently, development finer therapeutics that outshine existing ones is far-reaching. Natural compounds enormous applications curbing disastrous fatal diseases. Oroxylin A (OA) flavonoid obtained from plants
Language: Английский
Citations
42