Podocyte injury and death: New insights into lupus nephritis pathogenesis and therapy DOI Creative Commons
Xiaolei Shi, Zhipeng Wang, Ruihan Tang

et al.

Rheumatology & autoimmunity, Journal Year: 2023, Volume and Issue: 3(4), P. 193 - 204

Published: Dec. 1, 2023

Abstract Lupus nephritis (LN), an immune complex‐mediated glomerulonephritis, is one of the most severe complications systemic lupus erythematosus. Current therapeutic regimens for LN mainly involve nonspecific immunosuppressants and biologics targeting cells, but these treatments are not always effective some patients nonresponsive susceptible to recurrence. Podocytes essential maintaining glomerular filtration barrier. Injury loss podocytes lead proteinuria, a hallmark renal involvement LN. are, therefore, emerging as prospective targets There numerous mechanisms underlying podocyte malfunction in LN, with autophagy, mitochondrial dysregulation, programmed cell death being main processes behind loss. This review summarizes recent advances understanding dysfunction pathogenesis discusses potential interventions

Language: Английский

Obtusifolin inhibits podocyte apoptosis by inactivating NF-κB signaling in acute kidney injury DOI
Haiyan Xiang,

Yan Wu,

Yun Zhang

et al.

Cytotechnology, Journal Year: 2024, Volume and Issue: 76(5), P. 559 - 569

Published: June 21, 2024

Language: Английский

Citations

1
Podocyte injury and death: New insights into lupus nephritis pathogenesis and therapy DOI Creative Commons
Xiaolei Shi, Zhipeng Wang, Ruihan Tang

et al.

Rheumatology & autoimmunity, Journal Year: 2023, Volume and Issue: 3(4), P. 193 - 204

Published: Dec. 1, 2023

Abstract Lupus nephritis (LN), an immune complex‐mediated glomerulonephritis, is one of the most severe complications systemic lupus erythematosus. Current therapeutic regimens for LN mainly involve nonspecific immunosuppressants and biologics targeting cells, but these treatments are not always effective some patients nonresponsive susceptible to recurrence. Podocytes essential maintaining glomerular filtration barrier. Injury loss podocytes lead proteinuria, a hallmark renal involvement LN. are, therefore, emerging as prospective targets There numerous mechanisms underlying podocyte malfunction in LN, with autophagy, mitochondrial dysregulation, programmed cell death being main processes behind loss. This review summarizes recent advances understanding dysfunction pathogenesis discusses potential interventions

Language: Английский

Citations

3