Revolutionizing pancreatic islet organoid transplants: Improving engraftment and exploring future frontiers
Noella Abraham,
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Tejaswini Kolipaka,
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Giriraj Pandey
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et al.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
343, P. 122545 - 122545
Published: March 6, 2024
Language: Английский
The Evolving Function of Vasculature and Pro-angiogenic Therapy in Fat Grafting
Cell Transplantation,
Journal Year:
2024,
Volume and Issue:
33
Published: Jan. 1, 2024
Autologous
fat
grating
is
a
widely-accepted
method
to
correct
soft
tissue
deficiency.
Although
transplantation
shows
excellent
biocompatibility
and
simple
applicability,
the
relatively
low
retention
rate
caused
by
necrosis
still
challenge.
The
vasculature
integral
after
grafting,
serving
multiple
crucial
functions.
Rapid
effective
angiogenesis
within
grafts
essential
for
supplying
oxygen
necessary
adipocytes'
survival.
It
facilitates
influx
of
inflammatory
cells
remove
necrotic
adipocytes
aids
in
delivery
regenerative
adipose
regeneration
grafts.
also
provides
niche
interaction
between
progenitor
vascular
cells,
enhancing
adipogenesis
Various
methods,
such
as
enriching
with
diverse
pro-angiogenic
or
utilizing
cell-free
approaches,
have
been
employed
enhance
angiogenesis.
Beige
dedifferentiated
could
increase
vessel
density.
This
review
aims
outline
function
grafting
discuss
different
cell
approaches
that
can
following
grafting.
Language: Английский
Effect of Different Fatty Acid Types on Mitochondrial Dysfunction Associated With Brown and Beige Adipose Tissue
Nutrition Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Abstract
Adipose
tissue
serves
as
a
dynamic
endocrine
organ
that
is
pivotal
in
metabolic
regulation.
Augmenting
mitochondrial
activity
within
this
holds
promise
combating
obesity.
Mitochondrial
function
intricately
modulated
by
diverse
fatty
acid
compositions.
This
comprehensive
review
aimed
to
elucidate
the
molecular
mechanisms
underlying
dysfunction
induced
various
profiles.
While
saturated
acids
(SFAs)
pose
threat
integrity,
polyunsaturated
(PUFAs),
notably
n-3,
mitigate
SFA-induced
damage,
concurrently
regulating
thermogenic
gene
expression.
With
regard
monounsaturated
(MUFAs),
their
impact
on
adipose
remains
relatively
unexplored.
Although
human
studies
are
imperative
for
insights,
prioritizing
consumption
of
n-3
and
MUFAs
has
emerged
strategic
approach,
potentially
enhancing
biogenesis
pathways.
synthesis
underscores
critical
need
further
investigation
differential
effects
types
mitochondria,
offering
potential
avenues
obesity
intervention.
Language: Английский
Low‐Crosslinked Hydrophilic Decellularized Adipose Matrix Hydrogels Achieve Efficient and Functional Xenotransplant Fat Regeneration by Optimizing Stem Cell Niche
Xiaomu Ma,
No information about this author
Yue Qiang,
No information about this author
Su Fu
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et al.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Abstract
Xenogeneic
decellularized
adipose
matrix(DAM)
scaffolds
are
significant
in
soft
tissue
regeneration
by
addressing
donor
site
morbidity
and
limited
availability.
However,
natural
DAM
xenotransplantation
remains
unachieved.
Previous
efforts
have
relied
on
chemical
modifications
to
reduce
foreign
body
reactions,
with
inherent
drawbacks
outcomes.
This
study
proposes
a
hydrogel
scaffold
that
achieves
efficient
functional
xenotransplant
fat
regeneration.
Primarily,
hydrophilic
DAM(H‐DAM)
is
confirmed
lower
antigen
content,
but
its
regenerative
potential
constrained
encapsulation
impedes
seed
cell
infiltration.
Thus,
H‐DAM
prepared
enhance
the
speed
extent
of
It
observed
topological
structure
impacts
infiltration,
immune
inflammatory
response,
Low‐crosslinked
hydrogels
emerged
as
optimal
for
adipogenic
differentiation
due
loose
networks
degradation
rates
synchronizing
Furthermore,
wall‐like
rather
than
filamentous
provides
superior
niche
stem
engraftment
activity.
Finally,
integrated
multi‐omics
data
analysis
demonstrated
regenerated
functionally
mimics
native
tissue.
These
findings
indicate
xenogeneic
gel
support
both
structural
reconstruction
tissue,
offering
novel
insights
promising
approach
clinical
translation
DAM‐based
therapies.
Language: Английский
ECM-mimicking hydrogel models of human adipose tissue identify deregulated lipid metabolism in the prostate cancer-adipocyte crosstalk under antiandrogen therapy
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
30, P. 101424 - 101424
Published: Dec. 25, 2024
Language: Английский