Revolutionizing bone healing: the role of 3D models DOI Creative Commons
Raffaella De Pace, Maria Rosa Iaquinta,

Assia Benkhalqui

et al.

Cell Regeneration, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 21, 2025

Abstract The increasing incidence of bone diseases has driven research towards Bone Tissue Engineering (BTE), an innovative discipline that uses biomaterials to develop three-dimensional (3D) scaffolds capable mimicking the natural environment tissue. Traditional approaches relying on two-dimensional (2D) models have exhibited significant limitations in simulating cellular interactions and complexity microenvironment. In response these challenges, 3D such as organoids spheroids emerged effective tools for studying regeneration. Adult mesenchymal stem cells proven crucial this context, they can differentiate into osteoblasts contribute tissue repair. Furthermore, integration composite shown substantial potential enhancing healing. Advanced technologies like microfluidics offer additional opportunities create controlled environments cell culture, facilitating more detailed studies These advancements represent a fundamental step forward treatment pathologies promotion skeletal health. review, we report evolution vitro culture applied study healing/regrowth, starting from 2 cultures microfluids. different methodologies model generation, are presented discussed.

Language: Английский

Integral invariant manifold method applied to a mathematical model of osteosarcoma DOI Creative Commons
Ophir Nave

Results in Control and Optimization, Journal Year: 2025, Volume and Issue: unknown, P. 100529 - 100529

Published: Jan. 1, 2025

Language: Английский

Citations

0
Revolutionizing bone healing: the role of 3D models DOI Creative Commons
Raffaella De Pace, Maria Rosa Iaquinta,

Assia Benkhalqui

et al.

Cell Regeneration, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 21, 2025

Abstract The increasing incidence of bone diseases has driven research towards Bone Tissue Engineering (BTE), an innovative discipline that uses biomaterials to develop three-dimensional (3D) scaffolds capable mimicking the natural environment tissue. Traditional approaches relying on two-dimensional (2D) models have exhibited significant limitations in simulating cellular interactions and complexity microenvironment. In response these challenges, 3D such as organoids spheroids emerged effective tools for studying regeneration. Adult mesenchymal stem cells proven crucial this context, they can differentiate into osteoblasts contribute tissue repair. Furthermore, integration composite shown substantial potential enhancing healing. Advanced technologies like microfluidics offer additional opportunities create controlled environments cell culture, facilitating more detailed studies These advancements represent a fundamental step forward treatment pathologies promotion skeletal health. review, we report evolution vitro culture applied study healing/regrowth, starting from 2 cultures microfluids. different methodologies model generation, are presented discussed.

Language: Английский

Citations

0