SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116917 - 116917

Published: June 21, 2024

Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass, strength, and physical function, severely affecting the quality of life (QoL) elderly population. Sirtuin 1 (SIRT1), as a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, has been reported to participate in various signaling pathways exert protective effect on many human diseases. SIRT1 functioned important role occurrence progression sarcopenia through regulating key related protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance autophagy muscle, including SIRT1/Forkhead Box O (FoxO), AMP-activated kinase (AMPK)/SIRT1/nuclear factor κB (NF-κB), SIRT1/p53, AMPK/SIRT1/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), SIRT1/live B1 (LKB1)/AMPK pathways. However, specific mechanisms these processes have not fully illuminated. Currently, several SIRT1-mediated interventions preliminarily developed, such activator polyphenolic compounds, exercising calorie restriction. In this review, we summarized predominant involved therapeutic modalities targeting for prevention prognosis sarcopenia.

Language: Английский

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Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 427 - 427

Published: Jan. 31, 2024

In recent decades, following the spread of obesity, metabolic dysfunction has come to represent leading cause liver disease. The classical clinical presentation cirrhotic patient has, therefore, greatly changed, with a dramatic increase in subjects who appear overweight or obese. Due an obesogenic lifestyle (lack physical activity and overall malnutrition, excess caloric intake together deficit proteins micronutrients), these patients frequently develop complex condition defined as sarcopenic obesity (SO). interplay between cirrhosis SO lies sharing multiple pathogenetic mechanisms, including malnutrition/malabsorption, chronic inflammation, hyperammonemia insulin resistance. presence worsens outcome patients, affecting morbidity mortality. International nutrition diseases societies strongly agree on recommending use food integral part healing process comprehensive management reduction intake, protein micronutrient supplementation sodium restriction. Based pathophysiological paths shared by SO, this narrative review aims highlight nutritional interventions currently advocated international guidelines, well provide hints possible role micronutrients nutraceuticals treatment multifaceted condition.

Language: Английский

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Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2367 - 2367

Published: May 18, 2023

Sarcopenia, the age-related loss of muscle mass and function increasing risk disability adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models aging wasting indicate that intake specific polyphenol compounds can be associated with myoprotective effects, improvements strength performance. Such findings have also been confirmed a smaller number human studies. However, gut lumen, polyphenols undergo extensive biotransformation microbiota into wide range bioactive compounds, which contribute to bioactivity on skeletal muscle. Thus, beneficial effects may consistently vary across individuals, depending composition metabolic functionality bacterial communities. The understanding such variability has recently improved. For example, resveratrol urolithin interaction produce different biological according metabotype. In frequently characterized dysbiosis, overrepresentation opportunistic pathogens, increased inter-individual variability, actions phenolic at level. These interactions should taken great consideration for designing effective nutritional strategies counteract sarcopenia.

Language: Английский

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Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3854 - 3854

Published: Sept. 4, 2023

Sarcopenic obesity, low muscle mass, and high body fat are growing health concerns in the aging population. This review highlights need for standardized criteria explores nutraceuticals as potential therapeutic agents. obesity is associated with insulin resistance, inflammation, hormonal changes, reduced physical activity. These factors lead to impaired activity, intramuscular accumulation, protein synthesis, resulting catabolism increased mass. Myostatin irisin myokines that regulate synthesis energy expenditure, respectively. Nutritional supplementation vitamin D calcium recommended increasing mass reducing content. Testosterone therapy decreases improves strength. Vitamin K, specifically menaquinone-4 (MK-4), mitochondrial function reduces damage. Irisin a hormone secreted during exercise enhances oxidative metabolism, prevents resistance bone quality. Low-glycemic-index diets green cardamom methods managing sarcopenic obesity. In conclusion, along dietary support, nutraceuticals, such D, calcium, natural agonists of or testosterone, can serve promising future alternatives.

Language: Английский

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Impact of Chinese herbal medicine on sarcopenia in enhancing muscle mass, strength, and function: A systematic review and meta‐analysis of randomized controlled trials

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2303 - 2322

Published: Feb. 29, 2024

Abstract Sarcopenia has become important to the public health with increase in aging population society. However, therapeutic effects of conventional approaches, including pharmacotherapy, exercise, and nutritional intervention, are far from satisfactory. Chinese herbal medicine is a new treatment format interesting possibilities sarcopenia been widely practiced. The study aims explore effectiveness sarcopenia. We comprehensively searched following electronic databases: Medline, EMBASE, APA PsycInfo, Cochrane Library, Web Science, PubMed, database establishment December 2022 (no language restrictions). Randomized controlled clinical studies on use were selected compliance PRISMA guidelines. Review Manager Stata used for statistical analysis mean difference standardized adopted. Of 277 identified studies, 17 eligible included our ( N = 1440 participants). results showed that can improve total efficiency (RR 1.29, 95% CI [1.21, 1.36], p < 0.00001) enhance muscle mass (SMD 1.02, [0.55, 1.50], 0.0001), strength measured by grip 0.66, [0.36, 0.96], 60°/s knee extension peak TQ (MD 5.63, [−0.30, 11.57], 0.06) function 6‐meter walking speed 1.34, [0.60, 2.08], 0.0004), short physical performance battery 1.50%, (1.05, 1.95), EuroQoL 5‐dimension 0.27, [−0.10, 0.65], 0.16), suggesting alone or combined ameliorating effect potential strategy funnel plot Egger's test indicated publication bias. To confirm conclusions, further high‐quality should be conducted.

Language: Английский

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In silico study to identify novel NEK7 inhibitors from natural sources by a combination strategy

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Language: Английский

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Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: a single nutrient, a whole food, and a whole diet approach

Proceedings of The Nutrition Society, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Oct. 17, 2024

Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults associated with an increased risk disability, frailty premature death. Finding cost-effective prevention treatment strategies for sarcopenia the growing ageing population therefore great public health interest. Although nutrition considered important factor aetiology sarcopenia, its potential and/or still being evaluated. Nutrition research utilises three main approaches to understand muscle-nutrition relationships, evaluating: single nutrients, whole foods diet effects - both alone or combined exercise. Applying these approaches, we summarise recent evidence from qualitative quantitative syntheses findings observational intervention studies healthy adults, those sarcopenia. We consider protein supplements, (fruits vegetables) Mediterranean as exemplars. There some beneficial supplementation ≥ 0·8 g/kg body weight/d on when exercise training sarcopenic adults. In contrast, function (strength physical performance) inconclusive. reasonably consistent epidemiological suggesting benefits higher fruits vegetables consumption better performance. Similarly, adherence studies. However, are lacking. This review discusses how current may inform development preventive optimal nutritional policy aimed at combatting

Language: Английский

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The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper.

Archives of Medical Science, Journal Year: 2023, Volume and Issue: unknown

Published: June 8, 2023

Muscle wasting is one of the main causes for exercise intolerance and ventilatory inefficiency in patients with heart failure a strong predictor frailty reduced survival. The prevalence sarcopenia at least 20% failure. Patients often have subclinical systemic inflammation, which may exert sustained effects on skeletal muscle. Besides exercise, nutrition should also be carefully evaluated as an appropriate diet selected nutraceuticals able to stimulate muscle anabolism inhibit catabolism. This review summarizes epidemiological clinical trial evidence supporting recommendations use anti-inflammatory properties provides overview state nutraceutical supplementation prevent and/or mitigate wasting.

Language: Английский

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Composites made of Ginkgo biloba fibers and polylactic acid exhibit non-isothermal crystallization kinetics

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127232 - 127232

Published: Oct. 2, 2023

Language: Английский

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Plant‐Derived Treatments for Different Types of Muscle Atrophy

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

With the development of medicine and chemistry, an increasing number plant-derived medicines have been shown to exert beneficial therapeutic on treatment various physical psychological diseases. In particular, by using chemistry methods, we are able examine chemical components plants effects these substances human body. Muscle atrophy (MA) is characterized decreased muscle mass function, caused multiple factors severely affects quality life patients. The multifactorial complex pathogenesis MA hinders drug research disease treatment. However, phytotherapy has achieved significant results in MA. We searched PubMed Web Science for articles related atrophy. After applying exclusion inclusion criteria, 166 79 met respectively. A total 173 were included study after excluding duplicates. important role phytoactives such as curcumin, resveratrol, ginsenosides (e.g., maintaining a positive nitrogen balance muscles exerting anti-inflammatory antioxidant effects) extensively studied. Unfortunately, dose not single cause, each cause its own unique mechanism injury. This review focuses mechanisms active plant provides insights into personalized

Language: Английский

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