Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta‐analysis

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 14(1), P. 57 - 70

Published: Dec. 13, 2022

Muscle ultrasound is an emerging tool for diagnosing sarcopenia. This review aims to summarize the current knowledge on diagnostic test accuracy of diagnosis We collected data from Ovid Medline, Embase and Cochrane Central Register Controlled Trials. Diagnostic studies using muscle detect sarcopenia were included. Bivariate random-effects models based sensitivity specificity pairs used calculate pooled estimates sensitivity, area under curves (AUCs) summary receiver operating characteristic (SROC), if possible. screened 7332 publications included 17 with 2143 participants (mean age range: 52.6-82.8 years). All had a high risk bias. The study populations, reference standards measurement methods varied across studies. Lower extremity muscles commonly studied, whereas thickness (MT) was most widely measured parameter, followed by cross-sectional (CSA). MTs gastrocnemius, rectus femoris, tibialis anterior, soleus, abdominis geniohyoid showed moderate (SROC-AUC 0.83, 8 studies; SROC-AUC 0.78, 5 AUC 0.82, 1 study; 0.76-0.78, 2 0.76, 0.79, study, respectively), vastus intermedius, quadriceps femoris transversus low (AUC 0.67-0.71, 3 0.64, 4 0.68, respectively). CSA biceps brachii gastrocnemius fascicle length also 0.70-0.90, 0.81, 0.78-0.80, echo intensity (EI) 0.52-0.67, 0.48-0.50, 0.43-0.49, 0.69, combination EI or better than either alone shows low-to-moderate depending different parameters, muscles, populations. quality indicators (e.g., EI) quantity MT) might provide accuracy.

Language: Английский

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Making the invisible visible: imaging techniques for assessing muscle mass and muscle quality in chronic kidney disease

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(3)

Published: Feb. 20, 2024

ABSTRACT Muscle wasting and low muscle mass are prominent features of protein energy (PEW), sarcopenia sarcopenic obesity in patients with chronic kidney disease (CKD). In addition, is associated strength, impaired function adverse clinical outcomes such as quality life, hospitalizations increased mortality. While assessment well justified, the skeletal should go beyond quantity. Imaging techniques provide means for non-invasive, comprehensive, in-depth infiltration ectopic fat. These include computed tomography (CT), magnetic resonance imaging (MRI) ultrasound. Dual X-ray absorptiometry also an technique, but one that only provides quantitative not qualitative data on muscle. The main advantage compared other methods bioelectrical impedance analysis anthropometry they offer higher precision accuracy. On hand, cost acquiring maintaining equipment, especially CT MRI, makes these less-used options available mostly research purposes. field CKD end-stage (ESKD), gaining attention evaluating quantity more recently fat infiltration. This review describes potential ESKD settings

Language: Английский

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Skeletal muscle estimation: A review of techniques and their applications

Clinical Physiology and Functional Imaging, Journal Year: 2024, Volume and Issue: 44(4), P. 261 - 284

Published: March 1, 2024

Abstract Quantifying skeletal muscle size is necessary to identify those at risk for conditions that increase frailty, morbidity, and mortality, as well decrease quality of life. Although strength, quality, physical performance have been suggested important assessments in the screening, prevention, management sarcopenic cachexic individuals, still a critical objective marker. Several techniques exist estimating size; however, each technique presents with unique characteristics regarding simplicity/complexity, cost, radiation dose, accessibility, portability are factors assessors consider before applying these modalities practice. This narrative review discussion centred on theory applications current non‐invasive diverse populations. Common instruments assessment include imaging such computed tomography, magnetic resonance imaging, peripheral quantitative dual‐energy X‐ray absorptiometry, Brightness‐mode ultrasound, non‐imaging like bioelectrical impedance analysis anthropometry. Skeletal can be acquired from methods using whole‐body and/or regional assessments, prediction equations. Notable concerns when conducting absence standardised image acquisition/processing protocols variation cut‐off thresholds used define low by clinicians researchers, which could affect accuracy prevalence diagnoses. Given importance evaluating size, it imperative practitioners informed their respective strengths weaknesses.

Language: Английский

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The diagnostic performance of phase angle for sarcopenia among older adults: A systematic review and diagnostic meta-analysis

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105754 - 105754

Published: Jan. 6, 2025

Language: Английский

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Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions

Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1696 - 1696

Published: April 27, 2024

Despite a better understanding of the mechanisms causing cancer cachexia (CC) and development promising pharmacologic supportive care interventions, CC persists as an underdiagnosed undertreated condition. contributes to fatigue, poor quality life, functional impairment, increases treatment related toxicity, reduces survival. The core elements such weight loss appetite should be identified early. Currently, addressing contributing conditions (hypothyroidism, hypogonadism, adrenal insufficiency), managing nutrition impact symptoms leading decreased oral intake (nausea, constipation, dysgeusia, stomatitis, mucositis, pain, depressed mood, or anxiety), addition agents when appropriate (progesterone analog, corticosteroids, olanzapine) is recommended. In Japan, clinical practice has changed based on availability Anamorelin, ghrelin receptor agonist that improved lean body mass, weight, appetite-related life (QoL) compared placebo, in phase III trials. Other therapeutic currently trials include Espindolol, non-selective β blocker monoclonal antibody GDF-15. future, single agent perhaps multiple medications targeting various may prove effective strategy. Ideally, these incorporated into multimodal interdisciplinary approach includes exercise nutrition.

Language: Английский

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Diagnostic test accuracy of serum creatinine and cystatin C-based index for sarcopenia: a systematic review and meta-analysis

Age and Ageing, Journal Year: 2024, Volume and Issue: 53(1)

Published: Jan. 1, 2024

Abstract Background Sarcopenia is an important prognostic factor, but its optimal screening methods remain challenging. Several new indices developed based on serum creatinine (Cr) and cystatin C (CysC) have been proposed to be diagnostic biomarkers for sarcopenia screening. Objective This review aimed evaluate the accuracy of Cr- CysC-based diagnosis. Methods We systematically searched MEDLINE, EMBASE, SCIE SCOPUS from inception 2 April 2023. Methodological quality was assessed using Quality Assessment Diagnostic Accuracy Studies-2 tool. A bivariate random-effects model used synthesise pooled sensitivity, specificity area under curves summary receiver operating characteristic (SROC-AUC). Results retrieved 936 publications included 16 studies with 5,566 participants (mean age ranged: 51.0–78.4 years, 50.2% men). The prevalence ranged 7.8 69.5%. All presented a moderate high risk bias. showed (pooled sensitivity: 0.67, 95% CI 0.57–0.75; specificity: 076, 0.67–0.83; SROC-AUC: 0.78, 0.74–0.81). Cr/CysC ratio most widely studied index, followed by Cr × eGFRcys index. Overall, both indicators had satisfactory comparable performance in sarcopenia. Conclusion Serum indices—the index—had evaluating may serve as surrogate markers However, further validation required verify these findings.

Language: Английский

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Ultrasound for body composition assessment: a narrative review

Internal and Emergency Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Language: Английский

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A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 5, 2025

Abstract Background The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the maximum muscle circumference (CMMC) measured by ultrasound and not reported. We aims to construct a predictive model for based on CMMC in hospitalized older patients. Methods This was retrospective controlled study of patients > 60 years age geriatric department Hunan Provincial People’s Hospital. were thoroughly evaluated questionnaires, laboratory, examinations, including measuring thickness using ultrasound. Patients categorized into non-sarcopenia groups according consensus diagnosis recommended Asian Working Group Sarcopenia 2019 (AWGS2). Independent predictors identified univariate multivariate logistic regression analyses, developed simplified. prediction performance models assessed sensitivity, specificity, area under curve (AUC) compared with independent predictors. Results found that patient age, albumin level (ALB), brachioradialis (BRMT), gastrocnemius lateral head (Glh MT), established simplified Logistic P = -4.5 + 1.4 × 1.3 ALB 1.6 BR MT 3.7 1.8 Glh MT, best cut-off value 0.485. AUC 0.884 (0.807–0.962), 0.837 (0.762–0.911), 0.927 (0.890–0.963), respectively. kappa coefficient this diagnostic criteria AWGS2 0.709. Conclusion constructed five variables: level, CMMC. could quickly predict

Language: Английский

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A wearable approach for Sarcopenia diagnosis using stimulated muscle contraction signal

Biomedical Engineering Letters, Journal Year: 2025, Volume and Issue: 15(2), P. 443 - 454

Published: Feb. 5, 2025

Sarcopenia is a rapidly rising health concern in the fast-aging countries, but its demanding diagnostic process hurdle for making timely responses and devising active strategies. To address this, our study developed evaluated novel sarcopenia diagnosis system using Stimulated Muscle Contraction Signals (SMCS), aiming to facilitate rapid accessible community settings. We recruited 199 adults from Wonju Severance Christian Hospital between July 2022 October 2023. SMCS data were collected surface electromyography sensors with wearable device exoPill. Their skeletal muscle mass index, handgrip strength, gait speed also measured as reference. Binary classification models trained classify each criterion diagnosing based on AWGS cutoffs. The binary achieved high discriminative abilities an AUC score near 0.9 criterion. When combining these criteria evaluations, proposed performance accuracy of 89.4% males 92.4% females, sensitivities 81.3% 87.5%, specificities 91.0% 93.8%, respectively. This significantly enhances diagnostics by providing quick, reliable, non-invasive method, suitable broad use. promising result indicates that contains extensive information about neuromuscular system, which could be crucial understanding managing more effectively. potential remote patient care personal management significant, opening new avenues monitoring proactive potentially other disorders.

Language: Английский

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Discriminative Ability and Associations of Sarcopenia Using Point-of-Care Ultrasound with Functional, Mobility and Frailty Status in Older Inpatients

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1603 - 1603

Published: Feb. 27, 2025

Background/Objectives: We aimed to assess the discriminative ability of point-of-care ultrasound (POCUS) rectus femoris (RF) detect sarcopenia and examine associations these measures with functional, mobility, frailty status among older inpatients. Methods: Data were analysed from 161 patients aged 70 years consecutively admitted a tertiary geriatric rehabilitation hospital between October December 2023. The RF thickness cross-sectional area (CSA) measured using POCUS applying validated cut-offs. Ability muscle based on bioelectrical impedance analysis (BIA) as reference standard was calculated receiver operating characteristics analyses (ROC). Second, either ultrasonographic thickness, or frailty, mobility multivariable logistic regression analyses. Results: Mean age 84.0 (standard deviation (SD) 6.1 years) 64.4% women. Overall, 31 (19.3%) had low grip strength mass BIA. mean CSA 13 mm (SD 4.1) 4.3 cm2 1.7), respectively. Correlation coefficients BIA-muscle r = 0.52 in males, versus 0.40 females. Both positively associated functional (adjusted odds ratio (OR) 9.3 (95% CI 3.7–23.4) 9.2 (3.6–23.7)) (OR 4.0 2.1–12.1) (1.8–10.4)). None significantly status. Conclusions: Rectus by showed fair BIA, suggesting that BIA measure different aspects health. A strong association suggest potential utility diagnostic evaluation hospitalised patients; however, further study is required. Research should focus establishing valid sex-specific cut-offs for mass, ultimate goal developing low-cost, bedside, sensitive toolkit detecting patients.

Language: Английский

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