The effect of low birth weight as an intrauterine exposure on the early onset of sarcopenia through possible molecular pathways

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(3), P. 770 - 780

Published: March 29, 2024

Sarcopenia, a musculoskeletal disease characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, presents significant challenges to global public health due its adverse effects on mobility, morbidity, mortality, healthcare costs. This comprehensive review explores intricate connections between sarcopenia low birth weight (LBW), emphasizing developmental origins (DOHaD) hypothesis, inflammatory processes (inflammaging), mitochondrial dysfunction, circadian rhythm disruptions, epigenetic mechanisms, genetic variations revealed through genome-wide studies (GWAS). A systematic search strategy was developed using PubMed identify relevant English-language publications sarcopenia, LBW, DOHaD, inflammaging, disruption, GWAS. The consist 46.2% reviews, 21.2% cohort studies, 4.8% 1.9% cross-sectional 13.4% animal 5.8% epigenome-wide book chapters. identified key factors contributing development, including DOHaD LBW impact influence clock genes, role theory suggests that induces alterations during foetal impacting long-term outcomes, early onset sarcopenia. correlates with reduced grip lean body mass in adulthood, increasing risk Chronic inflammation (inflammaging) dysfunction contribute linked increased oxidative stress dysfunction. Disrupted rhythms, regulated genes such as BMAL1 CLOCK, are associated both lipid metabolism, ageing process. Early-life exposures, induce modifications like DNA methylation (DNAm) histone changes, playing pivotal development. Genome-wide have candidate variants weakness, providing insights into disorder. emerges potential predictor reflecting intrauterine exposures outcomes. Understanding complex interplay is essential for elucidating pathogenesis developing targeted interventions. Future research GWAS underlying mechanisms LBW-associated warranted inform preventive strategies improve

Language: Английский

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Misinformation and Junk Science in Obstetrics Medical Malpractice

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(2), P. e073 - e073

Published: March 27, 2025

The practice of obstetrics continues to be influenced by concerns medical–legal liability. Whereas assessments clinical are commonly judged against society and community standards, issues injury causation often analyzed a more complex scientific integration anatomy, physiology, pathophysiology. Misinformation refers false or inaccurate information, especially that which is deliberately intended deceive; junk science theories flawed, unreliable, lacking in credibility. In the course obstetric litigation, both misinformation may expounded an attempt bolster case argument. These theories, though their appeal juries have adverse consequences on clinicians health care institutions unfortunately alter future practice. Herein presented several examples been used falsely attribute harm clinician. Together, medical societies courts should aim restrict use science.

Language: Английский

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Short- and longer-term growth and development of fat mass in preterm infants

Seminars in Fetal and Neonatal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101636 - 101636

Published: April 1, 2025

Language: Английский

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Decoding the Impact of Theabrownin on Skeletal Muscle Function in Gestational Diabetic Offspring: Insights from Integrated Metabolome and Transcriptome Analysis

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Gestational diabetes mellitus (GDM) often leads to long-term metabolic issues, including skeletal muscle dysfunction in the offspring, with traditional managements focusing solely on blood glucose regulation and not addressing structural changes. Theabrownin (TB), a polyphenol derived from Pu-erh tea, has known antioxidant benefits, but its effects function GDM offspring remain unclear. In this study, model was induced mice, their were treated by TB. Transcriptomic metabolomic analyses identified key genes metabolites involved lipid metabolism, oxidative stress, inflammation. TB treatment significantly improved reduced alleviated inflammation of offspring. Key (Fabp3, Acot1, Acot4) (Palmitic acid, Oleic acid) regulated Pathway analysis revealed that mitigates GDM-induced through modulation biosynthesis unsaturated fatty acids. These findings highlight potential theabrownin (TB) as therapeutic agent for improving metabolism. Further investigation is needed elucidate mechanisms evaluate effects.

Language: Английский

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Epigenomics of Cardio-Oncology

JACC CardioOncology, Journal Year: 2024, Volume and Issue: 6(5), P. 743 - 745

Published: Sept. 10, 2024

Language: Английский

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