Kinases and Phosphatases, Journal Year: 2025, Volume and Issue: 3(1), P. 3 - 3
Published: Feb. 6, 2025
Phosphodegrons are critical motifs that play a pivotal role in the regulation of protein stability and function via phosphorylation-dependent signaling pathways. These serve as recognition elements for ubiquitin ligases, facilitating targeted degradation proteins. By modulating key cellular processes such cell cycle progression, DNA repair, apoptosis, phosphodegrons essential maintaining homeostasis. Dysregulation has been implicated wide range diseases, including cancer neurodegenerative disorders, highlighting their potential therapeutic targets. This review provides an overview phosphodegron functions along with biological significance health disease. Additionally, we discuss current methodologies studying explore emerging trends identification targeting. synthesizing recent advances field, this article aims to offer insights into future directions challenges research, ultimately underscoring importance disease pathology.
Language: Английский