The Potential Mechanism of Soy Isoflavones in Treating Osteoporosis: Focusing on Bone Metabolism and Oxidative Stress

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Osteoporosis is divided into primary and secondary types. Primary osteoporosis may result from estrogen deficiency in postmenopausal women, imbalanced bone remodeling the elderly, or adolescent-type development. Secondary can be caused by factors like long-term glucocorticoid treatment, chronic kidney disease (CKD), deprivation, oxidative stress, diabetes, obesity. This review focuses on therapeutic potential of soy isoflavones for osteoporosis. At cellular level, isoflavones, as natural plant extracts phytoestrogens, are crucial osteoblastogenesis differentiation, osteoclastogenesis, osteoclast mineralization, marrow mesenchymal stromal cell differentiation. They also maintain calcium homeostasis regulating extracellular vitamin D levels. In terms mitigate it endoplasmic reticulum mitochondria, thus senescence, autophagy, processes. Moreover, relieve symptoms related to CKD inhibit secretion, which directly indirectly benefits treatment Overall, have treat enhancing health, metabolism, alleviating stress. Future research should explore phytoestrogens treating exploration focus clarifying safety, identifying side effects, determining optimal dosage regimen, developing strategies any adverse reactions. addition, further large-scale, multicenter human clinical trials necessary accurately evaluate actual effect

Language: Английский

Association of nuclear magnetic resonance-based metabolomics with bone health in the UK Biobank

Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117460 - 117460

Published: March 1, 2025

Language: Английский

Atherogenic index of plasma is associated with vertebral fracture: a longitudinal study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 28, 2025

Purpose The atherogenic index of plasma (AIP), recognized as a marker atherosclerosis, which also has profound impact on bone metabolism. However, research exploring the association between AIP and probability vertebral fractures in populations is still relatively scarce. study aims to evaluate individuals longitudinal study. Patients methods A total 1395 subjects who were older than 55 years underwent CT scans for lung cancer screening July 2019 2021 enrolled followed up duration ranging from 8 months 6 years. Among them, 91 experienced new fractures. Participants stratified into four groups based quartiles. was then assessed by cox proportional hazards model. Results incidence fracture decreased with increasing (p trend = 0.001). Kaplan-Meier survival analysis indicated that more likely occur patients low levels (log-rank, all P < 0.05). Multivariate Cox regression showed negatively associated even after accounting confounding factors (adjusted hazard ratio (aHR) 0.27, 95%CI 0.10-0.71 continuous AIP; aHR 0.48, 0.26-0.90 Q2; 0.41, 0.19-0.88 Q4, respectively). Subgroup such associations mainly observed male subjects. Restricted cubic splines further adjusting confounders overall population men, but not women. Conclusion Our demonstrated strong fracture. Low may be an factor

Language: Английский