The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 286 - 286

Published: April 23, 2025

Alterations in sympathetic nervous activity are evident response to changes body weight. Sympathetic and responses weight change regionalized, with alterations end organ function dependent on the occurring brain regulatory pathways invoked effector organs engaged. The obesity-induced activation of system likely contributes initiation worsening cardiometabolic risk factors, including elevated blood pressure, cardiac dysfunction, dyslipidaemia, increased fasting glucose, insulin resistance, non-alcoholic steatohepatitis. Unintended loss, as occurs cachexia, is driven, at least part, by nervous-stimulated thermogenesis. complexity regulation renders use global measures problematic development targeted therapies difficult, but these not without promise or precedent. Knowledge central peripheral involved has opened up opportunities for pharmacological, surgical, device-based approaches mitigating burden disease progression. In this narrative review, we elaborate weight, involved, cardiovascular metabolic risks associated perturbations regional activity.

Language: Английский

Does anamorelin have beneficial effects in advanced cancer patients with systemic inflammation in the real world?

Investigational New Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский