The unexpected loss of the ‘hunger hormone’ ghrelin in true passerines: a game changer in migration physiology DOI Creative Commons
Stefan Prost, Jean P. Elbers, Julia Slezacek

et al.

Royal Society Open Science, Journal Year: 2025, Volume and Issue: 12(3)

Published: March 1, 2025

Migratory birds must accumulate large amounts of fat prior to migration sustain long flights. In passerines, the small body size limits amount energy stores that can be transported, and therefore undergo cycles extreme fattening rapid exhaustion reserves. Research on these physiological adaptations was rattled by discovery have lost main vertebrate regulator deposition, leptin. Recent studies thus focused ghrelin, known as 'hunger hormone', a peptide secreted gastrointestinal tract regulate, e.g. food intake mass in vertebrates. Studies domestic species showed that, birds, ghrelin has effects opposite those described mammals such inhibiting instead promoting intake. Furthermore, recent shown administration influences migratory behaviour passerine birds. Using comparative genomics immunoaffinity chromatography, we show been Eupasseres after basic split from Acanthisitti about 50 Ma. We found receptor is still conserved passerines. The maintenance functional system suggests Eupasserines, another ligand replaced perhaps bypass feedback would hinder pre-migratory accumulation subcutaneous fat.

Language: Английский

The unexpected loss of the ‘hunger hormone’ ghrelin in true passerines: a game changer in migration physiology DOI Creative Commons
Stefan Prost, Jean P. Elbers, Julia Slezacek

et al.

Royal Society Open Science, Journal Year: 2025, Volume and Issue: 12(3)

Published: March 1, 2025

Migratory birds must accumulate large amounts of fat prior to migration sustain long flights. In passerines, the small body size limits amount energy stores that can be transported, and therefore undergo cycles extreme fattening rapid exhaustion reserves. Research on these physiological adaptations was rattled by discovery have lost main vertebrate regulator deposition, leptin. Recent studies thus focused ghrelin, known as 'hunger hormone', a peptide secreted gastrointestinal tract regulate, e.g. food intake mass in vertebrates. Studies domestic species showed that, birds, ghrelin has effects opposite those described mammals such inhibiting instead promoting intake. Furthermore, recent shown administration influences migratory behaviour passerine birds. Using comparative genomics immunoaffinity chromatography, we show been Eupasseres after basic split from Acanthisitti about 50 Ma. We found receptor is still conserved passerines. The maintenance functional system suggests Eupasserines, another ligand replaced perhaps bypass feedback would hinder pre-migratory accumulation subcutaneous fat.

Language: Английский

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