Gut Microbiota Profile and Functional Gastrointestinal Disorders in Infants: A Longitudinal Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 16, 2025

The gut microbiota is involved in modulating gastrointestinal function and consequently contributes to the manifestation of functional disorders (FGIDs). aim study was analyze composition infants with (infantile colic, constipation, gastroesophageal reflux, diarrhea) according age, environmental factors, clinical manifestations. laboratory examination 134 divided into two groups: group I (n = 82) FGIDs Rome IV criteria, four subgroups diarrhea), II 52) without FGIDs. To assess intestinal microbiota, a bacteriological analysis fecal samples performed. Infants presented an imbalance microflora, which characterized by significant decrease main representatives acidifying flora represented Lactobacillus, Bifidobacterium, Enterococcus high abundance proteolytic microorganisms from Enterobacteriaceae family such as Klebsiella species Escherichia coli. In born cesarean section or artificially fed, incidence dysbiosis significantly higher. microbial could be key occurrence first year life.

Language: Английский

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Diet, Physical Activity and Depression: Does Gastrointestinal Health Help Explain the Relationship Between Lifestyle Factors and Depression?

Nutrition Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Lifestyle factors such as diet and physical activity are involved in the development maintenance of depression, but mechanism by which these influence mental health remains unclear. The aim this study was to investigate whether gastrointestinal helps explain some relationship between lifestyle depression. used a cross-sectional design compare dietary intake, three groups, healthy (n = 235), lifetime depression 161) current 86). Dietary intake measured Fruit And Vegetable VAriety index, N-3 PUFA Food Frequency Questionnaire Prebiotic Probiotic Questionnaire. Analysis variance, Pearson correlations Hayes PROCESS macro mediation analysis were groups examine relationships. Physical differed significantly with no differences overall fruit vegetable, omega-3 probiotic food intake. Bootstrapped showed that higher vegetable associated lower symptom scores, effects weak. Furthermore, occurrence symptoms moderately scores. Results from series exploratory analyses suggested mediated status. These data indicate on might partly work through system. findings help further understand mechanisms activity, can inform future longitudinal experimental studies.

Language: Английский

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Advances in gut-lung axis research: clinical perspectives on pneumonia prevention and treatment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

In recent years, the study of interaction between gut microbiota and distant organs such as heart, lungs, brain, liver has become a hot topic in field microbiology. With deeper understanding its immune regulation mechanisms action, these findings have increasingly highlighted their guiding value clinical practice. The is not only largest digestive organ human body but also habitat for most microorganisms. Imbalances microbial communities been associated with various lung diseases, allergic asthma cystic fibrosis. Furthermore, significant impacts on metabolic function responses. Their metabolites regulate gastrointestinal systems may affect lungs brain. As one common types respiratory system diseases worldwide, pulmonary infections high morbidity mortality rates. Pulmonary caused by dysfunction can lead to problems like diarrhea, further resulting imbalances within complex interactions that are abnormal manifestations under disequilibrium conditions. Meanwhile, interventions significantly modulate composition microbiota, alteration subsequently indicate susceptibility even contribute prevention or progression. This review delves into infections, elucidating latest advancements gut-lung axis research providing fresh perspective treatment pneumonia.

Language: Английский

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Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy

Published: May 27, 2024

SIBO is a pathology of the small intestine and may predispose individuals to range nutritional deficiencies. Very little known whether specific subtypes SIBO, such as hydrogen-dominant (H+), methane-dominant (M+), or hydrogen/methane –dominant (H+/M+), impact status dietary intake in patients. The aim this study was investigate possible correlations between biochemical parameters, nutrient intake, distinct subtypes. This observational included 67 patients who were newly diagnosed with SIBO. Biochemical parameters diet studied utilizing laboratory tests food records, respectively. H+/M+ group associated low serum vitamin D (p<0.001), ferritin (p=0.001) fiber (p=0.001). M+ correlated high folic acid (p=0.002) intakes lactose (p=0.002). H+ (p=0.027). These results suggest that subtype have varying effects on leading deficiencies body. Conversely, patterns development subtype. assessment diet, along diagnosis substype, are believed be key components therapy.

Language: Английский

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Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial

Medicine, Journal Year: 2024, Volume and Issue: 103(31), P. e39134 - e39134

Published: Aug. 2, 2024

Background: Irritable bowel syndrome (IBS) is a major global healthcare burden that requires effective and well-tolerated intervention. This study aimed to investigate the effectiveness safety of Bacillus coagulans BCP92, probiotic, in managing IBS symptoms. Methods: randomized controlled trial included 100 participants who strictly adhered protocol. Various parameters such as severity, digestive symptom frequency, gastrointestinal stool consistency, interleukin-6 levels, stress relief, anxiety levels were evaluated over 12 weeks. Results: B. BCP92 significantly improved severity ( P < .001), frequency .001) compared with control group. The consistency .001). Mental relief was remarkable = differentiating test groups. No significant change observed; however, assessment revealed an excellent profile no reported severe adverse events. Conclusion: one most promising therapeutic options for management because it has shown efficacy alleviating symptoms among patients suffering from this condition, resulting changes addition improving overall mental well-being its users, thereby foreseeing elimination any potential side effects experienced during implementation approach strategy within our health care system, patient outcomes leading individualization treatment plans all individuals diagnosed disease entity may have symptoms, including abdominal pain or discomfort associated habits.

Language: Английский

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