MicroRNAs: Potential prognostic and theranostic biomarkers in chronic lymphocytic leukemia

eJHaem, Journal Year: 2024, Volume and Issue: 5(1), P. 191 - 205

Published: Feb. 1, 2024

Abstract Small noncoding ribonucleic acids called microRNAs coordinate numerous critical physiological and biological processes such as cell division, proliferation, death. These regulatory molecules interfere with the function of many genes by binding 3'‐UTR region target mRNAs to inhibit their translation or even degrade them. Given that a large proportion miRNAs behave either tumor suppressors oncogenes, any genetic epigenetic aberration changeing structure and/or could initiate formation development. An example cancers is chronic lymphocytic leukemia (CLL), most prevalent adult in Western nations, which caused unregulated growth buildup defective cells peripheral blood lymphoid organs. Genetic alterations at cellular molecular levels play an important role occurrence development CLL. In this vein, it was noted disease noticeably affected changes expression miRNAs. Many studies on have shown these are pivotal prognosis different cancers, including CLL, (e.g., methylation) can predict progression response treatment. Furthermore, involved drug resistance targeting be considered new therapeutic approach for treatment disease. MiRNA screening offer information etiology Considering importance gene regulation, application diagnosis, prognosis, CLL reviewed paper.

Language: Английский

Patterns of microRNA and CD Expression Associated with Chronic Lymphocytic Leukemia in a Set of Sudanese Patients

Saudi Journal of Biomedical Research, Journal Year: 2024, Volume and Issue: 9(03), P. 33 - 41

Published: May 17, 2024

Background: CLL is an adult leukemia presented with a clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival patients, and determining first-line treatment. Methodology: The current research used lymphoma data obtained from El-Obeid Oncology Center. Included were details pertaining to patients who received their diagnoses between January 2018 2020. One hundred including sixty-one forty-nine without, made up full coverage sample. Immunohistochemistry molecular analyses conducted on subset individuals. Additionally, several underwent flow cytometry analysis for some CD markers as well microRNA prediction. Results: CD19 was shown positively expressed all studied (100%), while 88% non-CLL also showed same expression. Ninety-three percent nine examined CD5-positive expressions. Only 16.7% 66.7% tested positive CD22. Among studied, 92.3% CD23 expressions, no did. Every single patient every without negative CD38. We observed presence FMC70 analyzed samples two out three cases. evaluated predictive significance cohort 12 finding that around 83% Conclusion: more prevalent Sudan than reported global epidemiology common among elder men variants. According prognostic markers, has bad indicators.

Language: Английский

Fasting and Diet: Overview in Chronic Lymphocytic Leukemia

Hemato, Journal Year: 2024, Volume and Issue: 5(4), P. 420 - 433

Published: Oct. 19, 2024

Background: This review aims to provide an overview of the potential impact fasting and diet on cancer, in particular, chronic lymphocytic leukemia (CLL), which is most frequent form Western world. Methods: Experimental clinical studies have provided evidence crucial role enhancing cancer treatment improving outcomes for oncological patients, particularly at early stages disease. Results: Emerging highlights that creates a differential stress response under critical conditions by fostering survival normal cells while limiting growth cells. Pivotal CLL highlighted dietary components influence stromal microenvironment certain metabolic pathways, thereby affecting cell apoptosis immune response. In addition, explorative initial suggest specific diets can mitigate toxicity chemotherapy. Conclusions: Clinical trials are needed evaluate efficacy safety nutritional approaches CLL. Future investigations could new insights into prevention potentially leading more effective personalized therapeutic strategies.

Language: Английский