Dual Photoredox/Copper-Catalyzed Three-Component Alkylcyanation of Alkenes and 1,4-Alkylcyanation of 1,3-Enynes Employing Sulfoxonium Ylides as the Carbon Radical Precursors DOI
Zixuan Yang,

Xue-Cen Xu,

Bowen He

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

A novel dual photoredox/copper-catalyzed three-component alkylcyanation of alkenes and 1,4-alkylcyanation 1,3-enynes have been developed. In this radical cyanoalkylation reaction, the photoredox induced alkyl from sulfoxonium ylides adds to carbon-carbon double bonds styrenes or 1,3-enynes, generated benzylic allenyl radicals couple with a Cu(II) cyanide complex achieve selective cyanation. The reaction exhibits high chemo- regioselectivity wide substrate scope, providing an efficient method for synthesis nitriles in single step.

Language: Английский

Dual Photoredox/Copper-Catalyzed Three-Component Alkylcyanation of Alkenes and 1,4-Alkylcyanation of 1,3-Enynes Employing Sulfoxonium Ylides as the Carbon Radical Precursors DOI
Zixuan Yang,

Xue-Cen Xu,

Bowen He

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

A novel dual photoredox/copper-catalyzed three-component alkylcyanation of alkenes and 1,4-alkylcyanation 1,3-enynes have been developed. In this radical cyanoalkylation reaction, the photoredox induced alkyl from sulfoxonium ylides adds to carbon-carbon double bonds styrenes or 1,3-enynes, generated benzylic allenyl radicals couple with a Cu(II) cyanide complex achieve selective cyanation. The reaction exhibits high chemo- regioselectivity wide substrate scope, providing an efficient method for synthesis nitriles in single step.

Language: Английский

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