Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Autophagy is a degradative process that makes rapid turnover of old and impaired proteins organelles possible. It highly instigated by stress signals, like starvation, contributes to the cell’s homeostasis. performs crucial function in keeping cell genomic integrity stable. Impaired autophagic flux implicated neurodegenerative diseases, abnormal ageing, cancerous diseases. In diseases cancer, autophagy dualistic function; it can have both tumor-suppressive supportive role. initial phases tumorigenesis maintains genome and, if fails, leads death, thus having Meanwhile, also imparts pro-survival mechanism latter stages supports cells surviving conditions hypoxia increased oxidative stress. helps develop drug resistance some cases. Thus, modulation possible therapeutic strategy cancer therapy as its inhibition sensitise anti-cancerous drugs. The promotion autophagy, cases, safeguard from toxic protein aggregation enhanced Excessive result death. regulates several cellular processes death pathways, apoptosis. Therefore, an in-depth knowledge regulating molecules critically important. Pharmaceutical small or target help modulate context specific disease conditions.

Language: Английский