Unraveling the interaction mechanism between orphan drug Nitisinone and bovine serum albumin through spectroscopic and in silico approaches DOI
Mehmetcan Bilkay,

Sule Yazıcı,

Cem Erkmen

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 322, P. 124818 - 124818

Published: July 15, 2024

Language: Английский

Co-Existing Nanoplastics Further Exacerbates the Effects of Triclosan on the Physiological Functions of Human Serum Albumin DOI Creative Commons
Yan Bao, Yaoyao Wang, Hongbin Liu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 16, 2025

The potential health risks posed by the coexistence of nanoplastics (NPs) and triclosan (TCS) have garnered significant attention. However, effects underlying mechanisms NPs TCS on key functional proteins at molecular level remain poorly understood. This study reports effect polystyrene (PSNPs) binding to human serum albumin (HSA) using multispectral methods simulation systems. experimental results show that significantly inhibits HSA esterase activity, with exacerbating inhibition in presence PSNPs, which is attributed alteration conformation microenvironment amino acid residues induced PSNPs. Molecular docking site marker competitive studies indicate predominantly binds I subdomain Sudlow II PSNPs does not affect sites. Spectra analyses quenching mechanism between belongs static type change fluorescence type. conformational alterations are further enhanced indicating enhance making more accessible provides valuable information about toxicity case co-exposure.

Language: Английский

Citations

0
Biophysical and structural insights into Azamethiphos-DNA interactions DOI
Pratik Singh, Priyanka Gopi,

Majji Sai Sudha Rani

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125934 - 125934

Published: Feb. 23, 2025

Language: Английский

Citations

0
Evaluating the carcinogenic potential of Trazodone Hydrochloride via duplex DNA targeting: Molecular Interaction, Binding Mechanism and Affinity Assessment via Structural Calculations DOI
Palak Sharma, Shweta Singh, Priyanka Gopi

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 263, P. 116881 - 116881

Published: April 20, 2025

Language: Английский

Citations

0
Hemoglobin Targeting Potential of Aminocarb Pesticide: Investigation into Dynamics, Conformational Stability, and Energetics in Solvent Environment DOI
Shweta Singh, Priyanka Gopi, Palak Sharma

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 736, P. 150896 - 150896

Published: Oct. 25, 2024

Language: Английский

Citations

1
Unraveling the interaction mechanism between orphan drug Nitisinone and bovine serum albumin through spectroscopic and in silico approaches DOI
Mehmetcan Bilkay,

Sule Yazıcı,

Cem Erkmen

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 322, P. 124818 - 124818

Published: July 15, 2024

Language: Английский

Citations

0