もやもや病の慢性脳虚血に伴うCNS-interstitial fluidopathyと脳血行再建術後の変化 DOI Open Access
Shoko Hara, Shigeki Aoki, Taketoshi Maehara

et al.

Japanese Journal of Magnetic Resonance in Medicine, Journal Year: 2023, Volume and Issue: 44(1), P. 17 - 22

Published: Dec. 14, 2023

Moyamoya disease is a rare cerebrovascular of unknown origin that causes stenooclusive changes in major intracranial arteries and chronic cerebral ischemia. Although no fundamental cure exists, revascularization surgery can improve Recent studies have shown patients with moyamoya suffer from central nervous system (CNS) interstitial fluidopathy. Imaging findings CNS fluidopathy reported this include enlarged perivascular spaces, white matter hyperintensity, medullary streaks, free water measured multi-shell diffusion magnetic resonance imaging, an index diffusivity along the choroid plexus perfusion, volume. These are, at least some parts, reversible if improves Decreased arterial input may result disrupted function intramural peri-arterial drainage pathways glymphatic system, thus, CSF homeostasis. Because driving force waste clearance brain, it reasonable to infer homeostasis under ischemia induces pathological Alzheimer's disease. However, regarding aspect serum biomarkers positron emission tomography not revealed amyloid beta accumulation Further are required investigate whether should be treatment target for neuronal damage induced by

Language: Английский

Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease DOI
D. Botta,

Ioana Hutuca,

Elyas El Ghoul

et al.

Journal of Neuroradiology, Journal Year: 2025, Volume and Issue: 52(3), P. 101322 - 101322

Published: Jan. 31, 2025

Language: Английский

Citations

3
The glymphatic system in migraine and other headaches DOI Creative Commons

Maria Grazia Vittorini,

Aysenur Sahin,

Antonin Trojan

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: March 11, 2024

Abstract Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It made a network perivascular spaces, filled in cerebrospinal interstitial fluid, encompassing penetrating pial vessels communicating with subarachnoid space. separated by blood barrier tissue endfeet astrocytes rich aquaporin 4, membrane protein which controls water flow along Animal models magnetic resonance (MR) studies allowed to characterize glymphatic function determine how its impairment could lead numerous neurological disorders (e.g. Alzheimer’s disease, stroke, sleep disturbances, migraine, idiopathic normal pressure hydrocephalus). This review aims summarize role pathophysiology migraine order provide new ways approaching this disease therapy.

Language: Английский

Citations

16
Pathophysiology of cerebral small vessel disease: a journey through recent discoveries DOI Creative Commons
Nicolas Dupré, Antoine Drieu, Anne Joutel

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(10)

Published: May 14, 2024

Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related pathologies that affect multiple regions. Disease manifestations range from lesions incidentally detected on neuroimaging (white matter hyperintensities, deep infarcts, microbleeds, or enlarged perivascular spaces) to severe disability and cognitive impairment. cSVD accounts for approximately 25% ischemic strokes the vast majority spontaneous intracerebral hemorrhage is also most important vascular contributor dementia. Despite its high prevalence potentially long therapeutic window, there are still no mechanism-based treatments. Here, we provide an overview recent advances in this field. We summarize data highlighting remarkable continuum between monogenic multifactorial cSVDs involving NOTCH3, HTRA1, COL4A1/A2 genes. Taking vessel-centric view, discuss possible cause-and-effect relationships risk factors, structural functional changes, manifestations, underscoring some major knowledge gaps. Although endothelial dysfunction rightly considered central feature cSVD, contributions smooth muscle cells, pericytes, other cells warrant continued investigation.

Language: Английский

Citations

16
The glymphatic system and multiple sclerosis: An evolving connection DOI Creative Commons
Alaa Alghanimy, Lorraine M. Work, William M. Holmes

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105456 - 105456

Published: Jan. 21, 2024

Language: Английский

Citations

10
Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response DOI
Bo Jin,

Jiahui Xu,

Jing Hu

et al.

Seizure, Journal Year: 2025, Volume and Issue: 125, P. 31 - 36

Published: Jan. 1, 2025

Language: Английский

Citations

1
Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism DOI Creative Commons
Stefano Sotgiu, Vanna Cavassa, Mariangela Valentina Puci

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 9, 2025

The glymphatic system allows cerebrospinal fluid (CSF) flow along the brain's perivascular spaces (PVS), aiding in removal of harmful substances into venous system. Previous studies have suggested that younger males with severe autism spectrum disorder (ASD) exhibit enlarged PVS (ePVS), although specific regions or extent enlargement remain unclear. Additionally, it is still unknown whether localization ePVS correlates ASD symptoms. Using automated MRI-based quantification, we conducted a descriptive observational study to map number, diameter, and volume across 72 brain areas, correlating these features clinical severity presence absence three distinct symptoms: language impairment, stereotypies, hypersensoriality. involved 36 children (ages 1–9 years). A thorough analysis white matter underlying cortical areas revealed different symptoms localizations. Moreover, beneath two rostral middle frontal were associated overall as well (verbal dysfunction, hypersensoriality). When prefrontal subregions experience excessive enlargement, may lead hypoactivity dorsolateral cortex (DLPFC), contributing manifestation

Language: Английский

Citations

1
Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease DOI Creative Commons
Gemma Solé‐Guardia, Hao Li,

Luc Willemse

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(4)

Published: April 1, 2025

Abstract Cerebral small vessel disease (SVD) is recognized as a major vascular contributor to cognitive decline, ultimately leading dementia and stroke. While the pathogenesis of SVD remains unclear, emerging evidence suggests that waste clearance involving perivascular space (PVS) – also known glymphatic system dysfunction may play role. Among radiological markers, increased presence dilated PVS marker disruption. Recently developed neuroimaging methods have been proposed indirect measures brain fluid dynamics, but they currently lack formal validation. Here, we provide comprehensive overview latest advancements for assessing including function in SVD. We review mechanisms by which might contribute Finally, argue robust, multimodal, longitudinal studies are essential understanding (involving PVS) establishing diagnostic gold standard. Highlights The majority not visible on MRI, making it crucial understand how why become dilated. origin disruption be multifactorial. BBB likely affect each other, forming vicious cycle, promoting further amyloid beta accumulation. Yet their direct association humans over time studied. Comparative can aid standardization function.

Language: Английский

Citations

1
Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease DOI
Shoko Hara, Junko Kikuta, Kaito Takabayashi

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2024, Volume and Issue: 44(10), P. 1787 - 1800

Published: April 4, 2024

Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, waste clearance system. We evaluated 46 adult patients with MMD 33 age- sex-matched controls using diffusivity along perivascular space (ALPS) measured diffusion tensor imaging (ALPS index), partly reflect multishell MRI to generate freewater maps. Twenty-three were also via 15 O-gas positron emission tomography (PET), all underwent cognitive tests. Compared controls, (38.4 (13.2) years old, 35 females) had lower ALPS indices in left right hemispheres (1.94 (0.27) vs. 1.65 (0.25) 1.94 (0.22) (0.19), P < 0.001). While index showed no correlation, was correlated parenchymal ( ρ = −0.47, 0.001); perfusion PET (cerebral blood flow, 0.70, 0.001; mean transit time, −0.60, 0.003; oxygen extraction fraction, −0.52, 0.003); tests (trail making test part B for executive function; −0.37, 0.01). Adult exhibit decreased is degree increased interstitial freewater, dysfunction, but further investigation needed.

Language: Английский

Citations

6
3D Quantitative-Amplified Magnetic Resonance Imaging (3D q-aMRI) DOI Creative Commons
Itamar Terem, Kyan Younes, Nan Wang

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 851 - 851

Published: Aug. 20, 2024

Amplified MRI (aMRI) is a promising new technique that can visualize pulsatile brain tissue motion by amplifying sub-voxel in cine data, but it lacks the ability to quantify field physical units. Here, we introduce novel post-processing algorithm called 3D quantitative amplified (3D q-aMRI). This enables visualization and quantification of motion. q-aMRI was validated optimized on digital phantom applied

Language: Английский

Citations

4
Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct DOI
Salvatore Rudilosso, Emma Muñoz‐Moreno, Carlos Laredo

et al.

Neuroradiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0