Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders DOI Creative Commons
Emmanuel Ortega-Robles, Benito de Celis Alonso, Jessica Cantillo-Negrete

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 79 - 79

Published: Jan. 16, 2025

Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview their applications in this field, offering an updated perspective on potential for early diagnosis, monitoring, and therapeutic evaluation. Emerging MRI modalities such as neuromelanin-sensitive imaging, diffusion-weighted magnetization transfer relaxometry provide sensitive biomarkers that can detect microstructural degeneration, iron deposition, connectivity disruptions key regions like substantia nigra. These enable earlier more accurate differentiation disorders, including Parkinson's disease, progressive supranuclear palsy, multiple system atrophy, corticobasal Lewy body frontotemporal dementia, Huntington's dystonia. Furthermore, provides objective metrics tracking progression assessing efficacy, making it indispensable tool clinical trials. Despite these advances, absence standardized protocols limits integration routine practice. Addressing gap incorporating systematically could bring field closer to leveraging advanced personalized treatment strategies, ultimately improving outcomes individuals with disorders.

Language: Английский

Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders DOI Creative Commons
Emmanuel Ortega-Robles, Benito de Celis Alonso, Jessica Cantillo-Negrete

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 79 - 79

Published: Jan. 16, 2025

Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview their applications in this field, offering an updated perspective on potential for early diagnosis, monitoring, and therapeutic evaluation. Emerging MRI modalities such as neuromelanin-sensitive imaging, diffusion-weighted magnetization transfer relaxometry provide sensitive biomarkers that can detect microstructural degeneration, iron deposition, connectivity disruptions key regions like substantia nigra. These enable earlier more accurate differentiation disorders, including Parkinson's disease, progressive supranuclear palsy, multiple system atrophy, corticobasal Lewy body frontotemporal dementia, Huntington's dystonia. Furthermore, provides objective metrics tracking progression assessing efficacy, making it indispensable tool clinical trials. Despite these advances, absence standardized protocols limits integration routine practice. Addressing gap incorporating systematically could bring field closer to leveraging advanced personalized treatment strategies, ultimately improving outcomes individuals with disorders.

Language: Английский

Citations

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