Bidirectional causal associations between type 2 diabetes and COVID‐19

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Aug. 27, 2022

Abstract Observational studies have reported high comorbidity between type 2 diabetes (T2D) and severe COVID‐19. However, the causality T2D COVID‐19 has yet to be validated. We performed genetic correlation Mendelian randomization (MR) analyses assess relationships potential causal associations three outcomes (severe acute respiratory syndrome coronavirus [SARS‐CoV‐2] infection, hospitalization, critical COVID‐19). Molecular pathways connecting SARS‐CoV‐2 were reconstructed extract insights into mechanisms underlying connection. identified a overlap each outcome (genetic correlations 0.21–0.28). The MR indicated that liability confers effect on hospitalized (odds ratio 1.08, 95% confidence interval [CI] 1.04–1.12) (1.09, 1.03–1.16), while infection exerts (1.25, 1.00–1.56). There was suggestive evidence associated with an increased risk for (1.02, 1.00–1.03), (1.06, 1.00–1.13) 0.99–1.19) T2D. Pathway analysis panel of immunity‐related genes may mediate links at molecular level. Our study provides robust support bidirectional contribute amplifying severity COVID‐19, increase

Language: Английский

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COVID-19 and Selenium Deficiency: a Systematic Review

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(9), P. 3945 - 3956

Published: Nov. 5, 2021

Abstract Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and case COVID-19, several reported heterogeneous results concerning association with severity disease. To summarize available data surrounding body levels outcomes a systematic search was performed Medline database (PubMed), Scopus, Cochrane Library, Embase, Web Science using keywords including “SARS-CoV-2,” “COVID-19,” “selenium,” Studies evaluating COVID-19 were included. Among 1,862 articles viewed search, 10 included after title, abstract, full-text review. One study further searching literature again for any newly published articles. Out 11 studies, measured serum level, one investigated urinary level. Three SELENOP level as well Glutathione peroxidase-3 also assessed study. The severity, mortality, risk COVID-19. Nine lower is associated worse outcomes. Two no significant between In study, to higher severe fatal cases compared non-severe recovered patients, respectively. most cases, outcomes, patients than healthy individuals. Thus, it could concluded cautious supplementation helpful prevent disease progression. However, randomized clinical trials are needed confirm this.

Language: Английский

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Safety of SARS-CoV-2 vaccination during pregnancy- obstetric outcomes from a large cohort study

BMC Pregnancy and Childbirth, Journal Year: 2022, Volume and Issue: 22(1)

Published: Feb. 28, 2022

COVID-19 during pregnancy is associated with adverse outcomes for mother and fetus. SARS-CoV-2 vaccination has significantly reduced the risk of symptomatic disease. Several small studies have reported safety pregnancy, no effect on obstetric outcomes.To examine association between maternal neonatal in a large cohort study. Furthermore, to evaluate if timing related outcomes.A retrospective study women who delivered December 2020 July 2021 at tertiary medical center. Excluded were multiple prior infection or before unknown vaccination. Primary incidence preterm labor gestational age. Secondary other complications. A secondary analysis investigating time was also performed. Multivariable logistic regression models used adjust potential confounders.There 5618 met inclusion criteria: 2,305 (41%) vaccinated 3,313 (59%) unvaccinated. There differences non-vaccinated patients respect primary outcomes. The rate birth 5.5% group compared 6.2% unvaccinated (p = 0.31). Likewise, rates age comparable two groups (6.2% vs. 7.0% respectively, p 0.2). In focusing its relationship outcomes, second trimester (n 964) third 1329) independently their counterparts. Women more likely (8.1% 6.2%, < 0.001). This persisted after adjusting confounders (adjusted odds ratio 1.49, 95%CI 1.11, 2.01).SARS-CoV-2 vaccine appears be safe increase women. However, there may an birth.

Language: Английский

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Comparison of clinical features and perinatal outcomes between pre-variant and post-variant periods in pregnant women with SARS-CoV-2: analysis of 1935 cases

Archives of Gynecology and Obstetrics, Journal Year: 2022, Volume and Issue: 306(6), P. 1939 - 1948

Published: March 7, 2022

Language: Английский

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COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss

Human Reproduction Update, Journal Year: 2023, Volume and Issue: 30(2), P. 133 - 152

Published: Nov. 28, 2023

Abstract BACKGROUND Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates be stillborn or admitted a neonatal unit. The World Health Organization declared in May 2023 an end the disease 2019 (COVID-19) pandemic as global health emergency. However, pregnant still becoming SARS-CoV-2 there is limited information available regarding effect of infection early pregnancy on outcomes. OBJECTIVE AND RATIONALE We conducted this systematic review determine prevalence loss SARS-Cov-2 compare risk without infection. SEARCH METHODS Our based prospectively registered protocol. search PregCov19 consortium was supplemented extra electronic specifically up 10 March PubMed, Google Scholar, LitCovid. included retrospective prospective studies infection, provided that they contained losses first and/or second trimester. Primary outcome miscarriage defined before 20 weeks gestation, however, reported 22 24 were also included. Additionally, we report occur at trimester specifying gestational age, for only when study presented stillbirths foetal separately from miscarriages. Data stratified into Secondary outcomes ectopic (any extra-uterine pregnancy), termination pregnancy. At least three researchers independently extracted data assessed quality. calculated odds ratios (OR) differences (RDs) corresponding 95% CI pooled using random effects meta-analysis. To estimate prevalence, performed meta-analysis proportions. Heterogeneity by I2. OUTCOMES 120 comprising total 168 444 infection; which 18 233 Evidence level considered low moderate certainty, mostly owing selection bias. did not find evidence association between (OR 1.10, 0.81–1.48; I2 = 0.0%; RD 0.0012, −0.0103 0.0127; 0%; 9 studies, 4439 women). Miscarriage occurred 9.9% (95% 6.2–14.0%; 68%; 46 1797 women) SARS CoV-2 1.2% 0.3–2.4%; 34%; 33 studies; 3159 proportion pregnancies 1.4% 0.02–4.2%; 66%; 14 950 Termination 0.6% 0.01–1.6%; 79%; 39 1166 WIDER IMPLICATIONS found no indication increases provide better estimates, well-designed needed include conception consider clinical manifestation severity loss, well potential confounding factors such previous loss. For practice, should advised take precautions avoid exposure receive vaccination.

Language: Английский

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Management of pregnant women with COVID‐19: A tertiary pandemic center experience on 1416 cases

Journal of Medical Virology, Journal Year: 2021, Volume and Issue: 94(3), P. 1074 - 1084

Published: Oct. 29, 2021

The aim of this study is to share the comprehensive experience a tertiary pandemic center on pregnant women with COVID-19 and compare clinical outcomes between pregnancy trimesters. present prospective cohort consisted who were followed up at Ankara City Hospital March 11, 2020 February 20, 2021. Clinical characteristics perinatal compared A total 1416 (1400 singletons 16 twins) evaluated. Twenty-six (1.8%) patients admitted intensive care unit (ICU) maternal mortality was observed in six (0.4%) cases. Pregnancy complications 227 (16.1%) cases preterm labor most common one (n = 42, 2.9%). There 311, 433, 672 first, second, third trimesters pregnancy, respectively. Rates mild severe/critic highest first second trimesters, hospitalization rate trimester. complications, mortality, NICU admission rates similar groups. course disease obstetric may be different among worse even without any coexisting health problems.

Language: Английский

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The utility of systemic immune‐inflammation index and systemic immune‐response index in the prediction of adverse outcomes in pregnant women with coronavirus disease 2019: Analysis of 2649 cases

Journal of Obstetrics and Gynaecology Research, Journal Year: 2022, Volume and Issue: 49(3), P. 912 - 919

Published: Dec. 29, 2022

To investigate the association of systemic immune-inflammation index (SII) and immune-response (SIRI) with adverse perinatal outcomes in pregnant women coronavirus disease 2019 (COVID-19).The cases were divided into (1) Mild-moderate COVID-19 group (n = 2437) (2) Severe-critical 212). Clinical characteristics, outcomes, SII (neutrophilXplatelet/lymphocyte), SIRI (neutrophilXmonocyte/lymphocyte) compared between groups. Afterward, values subgroups based on pregnancy complications, neonatal intensive care unit (NICU) admission, maternal mortality. A receiver operator characteristic analysis was performed for determination optimal cutoff prediction severity, NICU mortality.Both significantly higher complicated (p < 0.05). Cutoff severe-critical 1309.8 SII, 2.3 SIRI. For 973.2 1.6. 1045.4 1.8 calculated admission. Finally, cut-off 1224.2 2.4 found mortality.SII might be used combination other clinical findings poor outcomes.

Language: Английский

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Experiences of women in prenatal, childbirth, and postpartum care during the COVID-19 pandemic in selected cities in Brazil: The resignification of the experience of pregnancy and giving birth

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(5), P. e0284773 - e0284773

Published: May 5, 2023

The COVID-19 pandemic has impacted public and private health systems around the world, impairing good practices in women's care. However, little is known about experiences, knowledge, feelings of Brazilian women this period. objective was to analyze experiences women, seen at maternity hospitals accredited by Unified Health System (SUS, acronym Portuguese), regarding care during pregnancy, childbirth, postpartum periods, their interpersonal relationships, perceptions pandemic. This a qualitative, exploratory research, carried out three municipalities with hospitalized 2020, or period, not. For data collection, semi-structured individual interviews (in person, telephone, digital platform) were conducted, recorded transcribed. content analysis thematic modalities displayed as per following axes: i) Knowledge disease; ii) Search for prenatal, periods; iii) Experience suffering from COVID-19; iv) Income work; v) Family dynamics social support network. A total 46 interviewed São Luís-MA, Pelotas-RS, Niterói-RJ. Use media important convey information fight fake news. negatively access contributing worsening population's economic vulnerabilities. Women experienced diverse manifestations disease, psychic disorders very frequent. Social isolation disrupted network these who found strategies communication technologies. Women-centered care-including qualified listening mental support-can reduce severity cases pregnant, parturient, women. Sustainable employment income maintenance policies are essential mitigate vulnerabilities risks

Language: Английский

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Impact of COVID-19 on pregnant women in South Korea: Focusing on prevalence, severity, and clinical outcomes

Journal of Infection and Public Health, Journal Year: 2022, Volume and Issue: 15(2), P. 270 - 276

Published: Jan. 17, 2022

In the era of coronavirus disease 2019 (COVID-19) pandemic, there is a paucity information regarding actual prevalence COVID-19 in pregnant women compared to non-pregnant women. The purpose this study was investigate infection and clinical outcome women.This nationwide cross-sectional South Korea between January 2020 February 2021 using claim database. primary women, secondary occurrence severe illness among infected patients. Severity classified into four categories according WHO ordinal scale.The lower than aged 20-44 (0·02% vs. 0.14%, p < 0.0001). However, positive at age 20-44, higher risk oxygen therapy after hospitalization (score 4 scale: 6.4% 1.6%, 0.05). There were no deaths or hospitalized with COVID-19, although majority them (96·2%) admitted hospital. On other hand, 42·3% hospital 0.04% died 0.1% had disease.The Korea, resulting relatively small cases fatality. It has implications that public health policy, such as an effective response powerful preemptive strategy for can better outcomes COVID-19.

Language: Английский

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Decreased fetal cardiac output in pregnant women with severe SARS‐Cov‐2 infection

Echocardiography, Journal Year: 2022, Volume and Issue: 39(6), P. 803 - 810

Published: May 20, 2022

Abstract Aim We aimed to examine fetal cardiac output (CO) in patients who recovered from severe acute respiratory syndrome Coronavirus 2 (SARS‐CoV‐2) infection. Materials This prospective study included 48 pregnant women SARS‐CoV‐2 infection and 50 control cases. was diagnosed by polymerase chain reaction (PCR) test patients. Fetal echocardiographic evaluations were performed at 24–37 weeks of gestation the group. Results The median value ultrasound evaluation 34 (2.6) recovery (RSI) group, 32 (7.6) group ( p = .565). Left (LCO) z score significantly lower RSI than .041). LCO combine (CCO) disease mild, moderate groups, controls .019 .013). CCO (ml/min/kg) decreased when compared with mild groups .044). Conclusion In present study, found be reduced those disease, while there no significant difference Placental dysfunction inflammatory cytokines might cause changes. Further studies could clarified on impact function.

Language: Английский

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