There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Aifang Zhong, Yejun Tan, Yaqiong Liu

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(15)

Published: July 31, 2024

Background The association between poor cardiovascular health and cognitive decline as well dementia progression has been inconsistent across studies. This study used Mendelian randomization (MR) to investigate the causal relationship Alzheimer disease (AD), circulating levels of total‐tau, coronary artery (CAD). Methods Results MR AD or total‐tau CAD, including ischemic heart disease, myocardial infarction, atherosclerosis, failure. primary analysis inverse‐variance weighted method, with pleiotropy heterogeneity assessed using MR‐Egger regression Q statistic. overall results indicated that did not exhibit a effect on failure (odds ratio [OR], 0.969 [95% CI, 0.921–1.018]; P =0.209), infarction (OR, 0.972 0.915–1.033]; =0.359), 1.013 0.949–1.082]; =0.700), 1.005 0.937–1.078]; =0.881), atherosclerosis 0.987 0.926–1.052]; =0.690). No significant CAD was observed in reverse analysis. Additionally, our findings revealed influence nor increase risk CAD. Sensitivity assessment horizontal suggested these factors distort estimates. Conclusions this indicate absence direct from genetic perspective. Therefore, managing 2 diseases should be more independent targeted. Concurrently, investigating mechanism underlying their comorbidity may yield meaningful insights for advancing treatment strategies.

Language: Английский

Causal associations between COVID-19 and childhood mental disorders DOI Creative Commons
Fei Chen, Hongbao Cao, Ancha Baranova

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 8, 2023

Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade both the peripheral and central nervous systems impact function of brain. Therefore, it is necessary to evaluate mutual influences between COVID-19 outcomes childhood mental disorders. Methods We examined genetic correlations potential causalities three disorders phenotypes by genetically proxied analyses. included attention-deficit/hyperactivity disorder (ADHD, N = 292,548), Tourette’s (TS, 14,307), autism spectrum (ASD, 46,350). traits SARS-CoV-2 infection (N 2,597,856), hospitalized 2,095,324), critical 1,086,211). Literature-based analysis was used build gene-based pathways connecting ADHD COVID-19. Results positively correlated with (R g : 0.22 ~ 0.30). Our Mendelian randomization (MR) analyses found that confers a causal effect on (odds ratio (OR): 1.36, 95% confidence interval (CI): 1.10–1.69). TS (OR: 1.14, CI: 1.04–1.25). Genetic liability may not increase risk for Pathway identified several immunity-related genes link COVID-19, including CRP , OXT IL6 PON1 AR TNFSF12 IL10 . Conclusions study suggests augment severity through pathways. However, our results did support role in

Language: Английский

Citations

8
Unlocking the Protective Potential of Upper Respiratory Infection Treatment Histories against Alzheimer’s Disease: A Korean Adult Population Study DOI Open Access
Ho Suk Kang, Ji Hee Kim, Joo‐Hee Kim

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(1), P. 260 - 260

Published: Jan. 2, 2024

With increasing interest in the inflammation-pathogen infection hypothesis and its potential links to Alzheimer’s disease (AD) development, there is growing consideration of using upper respiratory (URI) treatments as interventions for AD. This nested case–control study explored association between prior URI histories AD development a Korean adult population national health screening cohort data (2002–2019). The included 26,920 patients 107,680 matched control individuals, focusing on those seeking treatment. Logistic regression analyses assessed impact treatment risk while adjusting covariates. Our results revealed that over 1-year period, individuals with (≥1, ≥2, or ≥3 instances) exhibited decreasing probabilities developing AD, reductions 19%, 15%, 12%, respectively. Expanding our investigation 2-year period consistently showed 17% reduction risk. effect remained robust across diverse demographic groups after covariates, encompassing comorbidities, hypertension, hyperlipidemia, blood glucose levels, lifestyle factors. Subgroup further substantiated this association. In conclusion, findings cautiously suggest protective role mitigating development.

Language: Английский

Citations

2
The role of exosome-shuttled miRNAs in heavy metal-induced peripheral tissues and neuroinflammation in Alzheimer's disease DOI Open Access
Qing Dong,

Huanyong Fu,

Hong Jiang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116880 - 116880

Published: June 7, 2024

Heavy metal-induced neuroinflammation is a significant pathophysiologic mechanism in Alzheimer's disease (AD). Microglia-mediated plays crucial role the pathogenesis of AD. Multiple miRNAs are differentially expressed peripheral tissues after heavy metal exposure, and increasing evidence suggests that they involved AD progression by regulating microglial homeostasis. Exosomes, which capable loading crossing bloodbrain barrier, serve as mediators communication between brain. In this review, we summarize current on link exposure propose for neurodegenerative phenotype (MGnD) This study will help to elucidate tissue damage MGnD-mediated exposure. Additionally, regulatory effects natural compounds tissue-derived miRNAs, could be potential therapeutic targets regulate exosomal ameliorate patients with

Language: Английский

Citations

2
Potential value and research frontiers of virus in neuroinflammation: a bibliometric and visualized analysis DOI Creative Commons
Danyang Li, Minghua Wu

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

Background Neuroinflammation represents the immune response of central nervous system to nerve injury, infection, toxin stimulation, or autoimmunity and is implicated in a wide range neurological disorders. Viruses play pivotal role as extrinsic biological drivers neuroinflammation; however, numerous aspects remain unexplored. In this study, we employed bibliometric analysis assess current status viral research neuroinflammation anticipate future directions emerging trends. Methods Conduct comprehensive search for scholarly publications within Web Science Core Collection database, with terms on virus. Apply Microsoft Excel Office, Hiplot, R (version 4.3.1), VOSviewer 1.6.20) CiteSpace (6.2.R6, advanced) software visualization. Results A total 4230 articles reviews virus were identified, demonstrating consistent upward trend over time. The United States was country that contributed most publications. Approximately 22274 authors from 4474 institutions research. Johns Hopkins University leads highest number citations. top three published field are Power, C., Lane, T. E., Buch, S. Journal authoritative choice researchers. main focuses include multiple sclerosis, Parkinson’s disease, blood-brain barrier, COVID-19, Alzheimer’s gene therapy. recent years, stress have emerged hot keywords, particularly depression, human immunodeficiency virus-associated neurocognitive disorders, gut microbiota related directions, indicating potential shift focus. Conclusion Research has attracted increasing attention past decade. European American countries been conducting neuroinflammation, while China produced significant publications, its impact still limited. Stress likely emerge next area focus field. association regulation between infection psychiatric disorders not fully understood, further needed explore caused by different types

Language: Английский

Citations

2
There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Aifang Zhong, Yejun Tan, Yaqiong Liu

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(15)

Published: July 31, 2024

Background The association between poor cardiovascular health and cognitive decline as well dementia progression has been inconsistent across studies. This study used Mendelian randomization (MR) to investigate the causal relationship Alzheimer disease (AD), circulating levels of total‐tau, coronary artery (CAD). Methods Results MR AD or total‐tau CAD, including ischemic heart disease, myocardial infarction, atherosclerosis, failure. primary analysis inverse‐variance weighted method, with pleiotropy heterogeneity assessed using MR‐Egger regression Q statistic. overall results indicated that did not exhibit a effect on failure (odds ratio [OR], 0.969 [95% CI, 0.921–1.018]; P =0.209), infarction (OR, 0.972 0.915–1.033]; =0.359), 1.013 0.949–1.082]; =0.700), 1.005 0.937–1.078]; =0.881), atherosclerosis 0.987 0.926–1.052]; =0.690). No significant CAD was observed in reverse analysis. Additionally, our findings revealed influence nor increase risk CAD. Sensitivity assessment horizontal suggested these factors distort estimates. Conclusions this indicate absence direct from genetic perspective. Therefore, managing 2 diseases should be more independent targeted. Concurrently, investigating mechanism underlying their comorbidity may yield meaningful insights for advancing treatment strategies.

Language: Английский

Citations

2