Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(12), P. 18659 - 18664
Published: Jan. 1, 2023
Language: Английский
Applied Sciences, Journal Year: 2023, Volume and Issue: 13(11), P. 6735 - 6735
Published: June 1, 2023
Oral lichen planus (OLP) is considered a T cell-mediated chronic inflammatory process activated by an unknown antigen, making basal keratinocytes vulnerable to cytotoxic cell mediated immune response. The aim of this review summarize information on the role and pathways Epstein–Barr virus (EBV) cells in inducing OLP as autoimmune lesion. pathogenesis analyzed from immunological aspects interactions between EBV oral mucosa. results available studies allow us assume that can act both exogenous endogenous antigen OLP. We emphasized antigen-presenting (APC), such dendritic (Langerhans cells, LC), detecting capturing antigens modulating adaptive Although shows tropism for B epithelial under certain conditions it infect monocytes, LCs, NK, lymphocytes. It means some circumstances process, particles react agents. During development decisive played loss tolerance. Factors like activity cytokines, chemokines, autoantibodies secreted EBV-positive plasma autoantigens formed due protein mimicry human proteins, new self-peptides released damaged tissues, self-reactive dysregulation LC function, anti-apoptotic effect early lytic antigens, imbalance anti-inflammatory facilitate process.
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8
Published: Jan. 1, 2024
Language: Английский
Citations
0
International Journal of Surgical Pathology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 21, 2024
Epstein-Barr virus (EBV) is a highly prevalent among adults worldwide. In an immunocompetent individual, EBV infection generally results in lifelong latency of the and no sequelae. However, setting immune dysfunction, can induce development autoimmune disorders, hyperplastic proliferations, cancers, including lymphoma. Here, we explore pathogenic oncogenic role Burkitt lymphoma, diffuse large B-cell Hodgkin plasmablastic lymphomatoid granulomatosis, post-transplant lymphoproliferative disorders associated with deficiency dysregulation. addition to describing general mechanisms EBV-associated oncogenesis, also discuss oncogenesis context each disorder, as well their microscopic, phenotypic, clinical presentations.
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37045 - e37045
Published: Aug. 28, 2024
BackgroundNumerous studies have investigated a possible correlation between Epstein-Barr virus (EBV) and autoimmune rheumatic diseases (ARDs). However, establishing cause-and-effect relationship remains challenging endeavor. This study employs Mendelian randomization to examine the impact of EBV nuclear antigen-1 antibody (EBNA-1) levels on susceptibility nine distinct ARDs, including rheumatoid arthritis (RA), primary Sjogren's syndrome (PSS), systemic lupus erythematosus (SLE), undifferentiated reactive (UA), sclerosis (SSc), adult-onset Still's disease (AOSD), psoriatic (PsA), dermatomyositis (DM), ankylosing spondylitis (AS).MethodsThe researchers applied two-sample approach, utilizing online data from separate cohorts European descent. We drew upon GWAS related EBNA-1 autoimmune-related disorders. Our analyses predominantly relied Inverse Variance Weighted methodology, complemented by range sensitivity assessments.ResultsOur analysis revealed significant direct associations risk developing PSS (95 % CI: 0.44 0.85, p = 0.003), PsA 0.36 0.99, 0.044), AS 0.07 0.88, 0.031), UA 0.56 0.96, 0.025). These results remained consistent through comprehensive analyses. no clear were found for other specified conditions.ConclusionsOur findings provide compelling evidence that play role in ARDs. enhance our understanding ARD pathogenesis hold substantial promise potential treatment strategies.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 29(2), P. 38 - 46
Published: May 1, 2024
Language: Английский
Citations
0
Russian Journal of Infection and Immunity, Journal Year: 2023, Volume and Issue: 13(3), P. 446 - 456
Published: March 7, 2023
The aim of the study was to investigate features changes in monocytes subset composition and phagocytic activity children with infectious mononucleosis (IM) exposed granulocyte-macrophage colony-stimulating factor (GM-CSF) vitro. We examined 84 aged 3 11 years EpsteinBarr virus (EBV) infection diagnosed by clinical signs, positive EBV DNA test blood lymphocytes ELISA data (EBV-VCAIgM (+), EBV-EA-DIgG (+)). control group consisted 40 apparently healthy age-matched children. Monocytes were obtained standard method on adhesion plastic from mononuclear cells isolated heparinized venous density gradient centrifugation. divided into two samples: (without GM-CSF) experimental (50 ng GM-CSF per 1 ml cell suspension). monocyte both samples measured flow cytometry after 1-hour incubation at 37C ina CO2-incubator. It found that progressing IM, subpopulation their is impaired. changed during development IM. Changes acute IM did not depend age (36 711 years) characterized increased number pro-inflammatory (intermediate) decreased level anti-inflammatory (non-classical) monocytes. Features altered depended age. all three subsets reduced 36 old while had only intermediate non-classical effect vitro patients regardless children, led significantly less. An increase for classical noted index this fraction remained unchanged. years. presented results determine scientific value studying mechanisms immune system prove cytokine can be used a new immunotherapeutic strategy treatment
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(12), P. 18659 - 18664
Published: Jan. 1, 2023
Language: Английский
Citations
0