Parvovirus B19 Outbreak in Israel: Retrospective Molecular Analysis from 2010 to 2023

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 480 - 480

Published: March 20, 2024

This study presents an analysis of the epidemiological trends parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on outbreak 2023. The utilized molecular diagnostic data individual patients obtained at Central Virology Laboratory. Between and 2022, 8.5% PCR-tested samples were positive for B19V, whereas this percentage surged 31% samples. Throughout period, annual cycles consistently peaked early spring/summer, most recent prominent occurring 2016. Predominantly, diagnoses made children women aged 20–39. Despite notable surge over 80% cases continued be observed young women, a decrease during winter months. Furthermore, genotype 1a virus remained predominant strain circulating outbreak. In light these circumstances, consideration should given implementing screening measures, particularly among high-risk groups such as pregnant women.

Language: Английский

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Population-Based Incidence of Infectious Mononucleosis and Related Hospitalizations: 2010 Through 2021

Mayo Clinic Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Molecular Epidemiology of Human Adenovirus from Acute Gastroenteritis Cases in Brazil After the COVID-19 Pandemic Period, 2021–2023

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 577 - 577

Published: April 17, 2025

Human enteric adenoviruses (HAdV-F40/41) play a crucial role as causative agents of acute gastroenteritis (AGE), particularly affecting children in low-and middle-income countries. This study investigated the prevalence, genetic diversity, and molecular characteristics HAdV-F40/41 AGE cases reported Brazil from 2021 to 2023, period after COVID-19 pandemic. A total 1980 stool samples collected medically attended patients nine states were analyzed by TaqMan-based qPCR. Overall, HAdV was detected 16.6% (n = 328/1980) cases, with highest prevalence observed under five years age. The positive genotyped through partial sequencing hexon and/or fiber genes followed phylogenetic analysis. Enteric HAdVs 3.2% 63/1980) samples, HAdV-F41 (44.1%) being most common genotype. Among non-enteric types, HAdV-C (29.4%) prevalent, HAdV-B (13.2%), HAdV-A (10.3%), HAdV-D (2.9%). Phylogenetic analysis (HVR1–HVR6) (Shaft) gene regions identified two major clusters, H-GTC1 F-GTC2, showing close relationships global strains. demonstrated significantly higher viral loads compared HAdVs. These findings highlight importance continued surveillance HAdV-F better understand its support public health strategies, including potential vaccine development.

Language: Английский

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The Outbreak of Unexplained Acute Hepatitis in Children: The Role of Viral Infections in View of the COVID-19 Pandemic

Viruses, Journal Year: 2024, Volume and Issue: 16(5), P. 808 - 808

Published: May 20, 2024

Background and Aims: An increase in the number of cases acute hepatitis unknown origin (HUO) children was observed 2021. Adenovirus adeno-associated virus 2 (AAV2) infections have been suggested as possible triggers. However, potential etiology is still unclear. We aimed to characterize a cohort with HUO Israel view COVID-19 pandemic. Method: Demographics, clinical data, laboratory results on compatible CDC criteria for were collected by established registry Ministry Health. Available specimens sent Central Virology Laboratory. Results: A total 39 included registry. 20 enrolled prospectively, which human herpes 6 (HHV6) infection or reactivation identified 11/19, adenovirus found 4/19 cases, AAV2 detected 2/16. Past exposure recorded 24/39 children. 10 underwent liver biopsy, 8 successfully treated steroids transplantation. Conclusions: The pandemic related containment measures combined active other viruses could trigger outbreak. In our cohort, HHV6 most abundant finding.

Language: Английский

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Learning from the universal, proactive outreach of the Brazilian Community Health Worker model: impact of a Community Health and Wellbeing Worker initiative on vaccination, cancer screening and NHS health check uptake in a deprived community in the UK

BMC Health Services Research, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 12, 2023

Abstract Background Delays in preventative service uptake are increasing the UK. Universal, comprehensive monthly outreach by Community Health and Wellbeing Workers (CHW), who integrated at GP practice local authority, offer a promising alternative to general public health campaigns as it personalises promotion prevention of disease holistically household level. We sought test ability this model, which is based on Brazilian Family Strategy, increase Methods Analysis primary care patient records for 662 households that were allocated five CHWWs from July 2021. Primary outcome was Composite Referral Completion Indicator (CRCI), measure how many activities received members relative ones they eligible during period 2021-April 2022. The CRCI compared between intervention group (those had least one visit) control (allocated yet receive visit). A secondary number visits groups study year prior. Results Intervention largely comparable terms occupancy eligibilities. total 2251 patients corresponding 5 CHWs 160 visit period. remaining included group. Overall 40% higher (CRCI: 0.21 ± 0.15 0.19 respectively). Likelihood immunisation specifically 47% cancer screening NHS Checks 82% higher. average consultations per decreased 7.4% over first 10 months pilot preceding its start, with 0.6% decrease Conclusions Despite short these findings deprived, traditionally hard reach community demonstrates potential worker model be impactful Further analysis needed examine if approach can reduce inequalities cost effectiveness approaches.

Language: Английский

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Predicting community acquired bloodstream infection in infants using full blood count parameters and C-reactive protein; a machine learning study

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(7), P. 2983 - 2993

Published: April 18, 2024

Early recognition of bloodstream infection (BSI) in infants can be difficult, as symptoms may non-specific, and culture take up to 48 h. As a result, many receive unneeded antibiotic treatment while awaiting the results. In this study, we aimed develop model that reliably identify who do not have positive blood cultures (and, by extension, BSI) based on full count (FBC) C-reactive protein (CRP) values. Several models (i.e. multivariable logistic regression, linear discriminant analysis, K nearest neighbors, support vector machine, random forest decision tree) were trained using FBC CRP values 2693 aged 7 60 days with suspected BSI between 2005 2022 tertiary paediatric hospital Dublin, Ireland. All tested showed similar sensitivities (range 47% - 62%) specificities 85%-95%). A tree applied dataset containing 2023 good segregation low-risk high-risk group. Negative predictive for these two high (> 99%) 97%), low both (4%-20%). Conclusion: We identified several predict days. Application could prevent administration antimicrobial burdensome diagnostics need them. What is Known: • Bloodstream cause non-specific difficult diagnose. Results hours. New: Machine learning contribute clinical making results are yet known.

Language: Английский

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Assessing the impact of COVID-19 non-pharmaceutical interventions and relaxation policies on Class B respiratory infectious diseases transmission in China

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 11, 2024

Language: Английский

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Global Impact of COVID-19 Pandemic on Gastrointestinal Infections: A Scoping Review

Foodborne Pathogens and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

During the COVID-19 pandemic, nonpharmaceutical public health interventions (NPIs) were implemented worldwide to control spread of severe acute respiratory syndrome coronavirus 2. However, incidence other pathogens, including gastrointestinal (GI) was also affected. Here, we reviewed studies assessing impact NPIs during pandemic on GI infections, particularly foodborne infections. A systems literature search conducted in May 2023, using Living Evidence (COAP) and Scopus. Articles identified selected through a screening process with inclusion exclusion criteria based Preferred Reporting Items for Systematic Reviews Meta-Analysis statement. Data extracted from each full-text article included review. Parameters viruses, bacteria, against associated pathogens. total 42 articles review, representing 18 countries. Overall, larger reduction observed viral infections compared bacterial norovirus. For

Language: Английский

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Epidemiological characteristics of community-acquired Mycoplasma pneumoniae in hospitalized children around COVID-19 from Jiangsu Province, China: a multicenter retrospective study

Translational Pediatrics, Journal Year: 2024, Volume and Issue: 13(12), P. 2155 - 2163

Published: Dec. 1, 2024

It has been reported that the emergence of coronavirus disease 2019 (COVID-19) changed epidemiological characteristics many pathogens, but Mycoplasma (MP) infection in hospitalized children with community-acquired pneumonia (CAP) are not clear. The aim this study was to answer question. Children CAP three tertiary hospitals (hospitals A, B and C) from 2018 2023 were selected. Data on gender, age, number date MP obtained medical record. intensity epidemic measured as a percentage CAP. In A B, before pandemic (in 2019), proportion total had shown significant upward trend, control measures led slight decline. hospital C, low during COVID-19 period. After lifted, increased sharply, aged more than 7 years old significantly 2022 2023. From 2019, there already an trend hospital. 2020 2022, after outbreak COVID-19, incidence stabilized, it broke out. This may be due severe restrictive taken early effectively controlled spread MP, pausing its pandemic.

Language: Английский

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