Machine learning versus multivariate logistic regression for predicting severe COVID‐19 in hospitalized children with Omicron variant infection

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(2)

Published: Feb. 1, 2024

Abstract With the emergence of Omicron variant, number pediatric Coronavirus Disease 2019 (COVID‐19) cases requiring hospitalization and developing severe or critical illness has significantly increased. Machine learning multivariate logistic regression analysis were used to predict risk factors develop prognostic models for COVID‐19 in hospitalized children with variant this study. Of 544 including 243 301 mild groups, respectively. Fever (92.3%) was most common symptom, followed by cough (79.4%), convulsions (36.8%), vomiting (23.2%). The showed that age (1–3 years old, odds ratio (OR): 3.193, 95% confidence interval (CI): 1.778–5.733], comorbidity (OR: 1.993, CI:1.154–3.443), 0.409, CI:0.236–0.709), baseline neutrophil‐to‐lymphocyte 1.108, CI: 1.023–1.200), lactate dehydrogenase 1.154–3.443), blood urea nitrogen 1.002, 1.000–1.003) total bilirubin 1.178, 1.005–3.381) independent COVID‐19. area under curve (AUC) prediction constructed machine (RandomForest + TomekLinks) 0.7770 0.8590, top 10 important variables random forest selected build a model, an AUC 0.8210. Compared regression, could more accurately infection.

Language: Английский

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COVID-19 has no impact on disease activity, progression and cognitive performance in people with multiple sclerosis: a 2-year study

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2023, Volume and Issue: unknown, P. jnnp - 332073

Published: Oct. 19, 2023

Sequelae of COVID-19 in people with multiple sclerosis (PwMS) have not been characterised. We explored whether is associated an increased risk disease activity, disability worsening, neuropsychological distress and cognitive dysfunction during the 18-24 months following SARS-COV-2 infection.

Language: Английский

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Influence of SARS-CoV-2 omicron variant infection on seizure occurrence among children: The large-scale multicenter study

Brain and Development, Journal Year: 2025, Volume and Issue: 47(3), P. 104341 - 104341

Published: March 29, 2025

Language: Английский

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Neurological manifestations and risk factors associated with poor prognosis in hospitalized children with Omicron variant infection

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(5), P. 2353 - 2363

Published: March 2, 2024

Language: Английский

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Pathophysiological, Neuropsychological, and Psychosocial Influences on Neurological and Neuropsychiatric Symptoms of Post-Acute COVID-19 Syndrome: Impacts on Recovery and Symptom Persistence

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2831 - 2831

Published: Dec. 13, 2024

Although the impact of post-acute COVID-19 syndrome (PACS) on patients and public health is undeniably significant, its etiology remains largely unclear. Much research has been conducted pathophysiology, shedding light various aspects; however, due to multitude symptoms clinical conditions that directly or indirectly define PACS, it challenging establish definitive causations. In this exploration, through systematically reviewing latest pathophysiological findings related neurological syndrome, we aim examine how psychosocial neuropsychological may overlap with ones, they not only serve as risk factors but also contribute persistence some primary disorder. Findings from our synthesis suggest psychological factors, such anxiety, depression, loneliness, interact in a self-reinforcing feedback loop. This cycle seems be affecting both physical distress, potentially increasing severity PACS symptoms. By pointing out interaction, review study, attempt offer new perspective interconnected nature psychological, psychosocial, emphasizing importance integrated treatment approaches disrupt improve outcomes when possible.

Language: Английский

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SARS-CoV-2 infectivity and antigenic evasion: spotlight on isolated Omicron sub-lineages

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 29, 2024

Since the SARS-CoV-2 outbreak in 2019, a diversity of viral genomic variants has emerged and spread globally due to increased transmissibility, pathogenicity, immune evasion. By first trimester 2023 Chile, as most countries, BQ XBB were predominant circulating sub-lineages Omicron. The molecular antigenic characteristics these have been mainly determined using non-authentic spike pseudoviruses, which is often described limitation. Additionally, few comparative studies isolates from recent Omicron conducted. In this study, we isolated clinical samples, including ancestral B.1.1, Delta, BA.1, BA.2 BA.5. We assessed their infectivity through cell culture infections antibody evasion neutralization assays. observed variations plaque size, morphology, cytotoxicity upon infection Vero E6-TMPRSS2 cells for each variant compared B.1.1 virus. BA.2-derived sub-variants, such XBB.1.5, showed attenuated replication, while BA.5-derived variants, BQ.1.1, exhibited replication rates similar Similar trends intestinal Caco-2 cells, except Delta. Antibody experiments sera individuals infected during COVID-19 wave (FWI) consistent but moderate reduction against sub-lineages. Interestingly, despite being less prevalent, BQ.1.1 6.1-fold greater escape than XBB.1.5. Neutralization patterns when tested vaccinated with 3xBNT162b2 (PPP) or Coronavac-Coronavac-BNT162b2 (CCP) schedules. However, CCP 2.3-fold higher XBB.1.5 FWI PPP sera. This study provides new insights into differences between leading eventual outcompetition. Our analysis offers important evidence regarding balance that drives evolution second-generation population.

Language: Английский

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Characteristics of SARS-CoV-2 Omicron BA.5 variants in Shanghai after ending the zero-COVID policy in December 2022: a clinical and genomic analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 28, 2024

Introduction An unprecedented surge of Omicron infections appeared nationwide in China December 2022 after the adjustment COVID-19 response policy. Here, we report clinical and genomic characteristics SARS-CoV-2 among children Shanghai during this outbreak. Methods A total 64 with symptomatic were enrolled. whole genome sequences obtained using next-generation sequencing (NGS) technology. Patient demographics compared between variants. Phylogenetic tree, mutation spectrum, impact unique mutations on proteins analysed silico. Results The monitoring revealed that emerging BA.5.2.48 BF.7.14 dominant more frequently observed to experience vomiting/diarrhea less present cough patients without comorbidities study. high-frequency non-synonymous (N:Q241K) (nsp2:V94L, nsp12:L247F, S:C1243F, ORF7a:H47Y) respect their parental lineages. Of these mutations, ORF7a:H47Y protein predicted have a deleterious effect function. Besides, nsp2:V94L nsp12:L247F destabilize proteins. Discussion Further vitro vivo studies are needed verify role specific viral fitness. In addition, continuous manifestation assessments variants will still be crucial for effective responses ongoing pandemic.

Language: Английский

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Complexity and Diversity of the Neurological Spectrum of SARS-CoV-2 over Three Waves of COVID-19

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3477 - 3477

Published: June 14, 2024

Background/Objectives: SARS-CoV-2 continually mutates, with five identified variants. Many neurological manifestations were observed during the COVID-19 pandemic, differences between virus The aim of this study is to assess frequency and characteristics in hospitalized patients over three waves Poland comparison analysis correlation course infection. Methods: This retrospective single-center included 600 consecutive adults confirmed COVID-19, 3 (pre-Delta, Delta Omicron) Poland. Demographic clinical information collected compared across periods. Results: median age group was 68, lower wave. In Omicron period, disease severity at admission inflammatory markers concentration lowest. Neurological 49%. most common altered mentation, headache, myalgia, mood disorder, ischemic stroke encephalopathy. Smell taste disturbances (STDs) less frequent period. complications predominant pre-Delta Ischemic more often Altered mentation related higher admission, worse lab test results, ICU mortality, while headache reduced mortality. Pre-existing dementia Conclusions: are frequent, a rate STDs period cerebrovascular diseases Headache improves comorbidities increase

Language: Английский

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Clinical characteristics and outcomes of children with COVID-19 in pediatric intensive care units during the Omicron wave in Taiwan

Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Since April 2022, the SARS-CoV-2 Omicron variant has caused a notable increase in pediatric COVID-19 cases Taiwan. During acute phase of infection, some children required admissions to intensive care units (PICU). This study aimed analyze their clinical presentations and outcomes while exploring associated factors. Medical records were retrospectively collected from patients with (aged <18 years) admitted our PICU 2022–March 2023. Early stage is defined as period without adequate vaccination treatment guidelines for April–June remaining months are referred late stage. Clinical characteristics compared between early stages. We enrolled 78 COVID-19, median length stay (LOS) 3 days 5% mortality rate. Patients during had lower rates (7% vs. 50%), higher logistic organ dysfunction scores (2 0.1), longer LOS (6 2 days) than those Multivariate analysis identified admission risk factor prolonged (>7 (odds ratio: 3.65, p = 0.047). Without available vaccinations suitable guidelines, tended have more severe illness PICU. These observations highlight importance familiarity medical providers management this newly-emerging infectious disease.

Language: Английский

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Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts

World Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 20(10), P. 1079 - 1089

Published: May 7, 2024

SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed analyze the specific symptoms of Omicron-infected improve patient care.

Language: Английский

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