The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 18 - 18

Published: Jan. 16, 2025

Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, major risk factor for cancer. This study aims investigate the relationship between cervicovaginal infections, and CIN development in 94 Romanian women with lesions. Comprehensive assessments included genotyping, cytology, colposcopy, histopathology. In 53.20% of cases, vaginal infections were identified, Candida albicans most frequently associated HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade 8.51% invasive carcinoma. There was strong correlation types (especially 16 18), colposcopic findings, histopathology, age. emphasizes mutual effect infection increasing developing cancer among women. Persistent types, particularly 18, has been confirmed as primary driver progression.

Language: Английский

---

Incidence of HPV, Cervical Cancer in China, and Its Potential Risk Factors and Protocols for Remedy

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Cervical cancer ranks as the fourth most prevalent globally among women, recording approximately 604,127 new cases and 341,831 fatalities in 2020. High-risk human papillomavirus (HPV) genotype infection is a significant risk factor for cervical cancer, one of leading causes cancer-related mortality women worldwide. In China, prevalence impact HPV have garnered increasing attention due to its substantial burden on public health. This chapter provides an in-depth exploration incidence, prevalence, factors, screening methods, prevention strategies, challenges associated with China. Drawing upon epidemiological data, clinical studies, health reports, this aims offer comprehensive understanding current landscape future directions combating HPV-related

Language: Английский

---

Risk Stratification in HPV-Associated Oropharyngeal Cancer: Limitations of Current Approaches and the Search for Better Solutions

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 357 - 357

Published: Jan. 22, 2025

The rising incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) necessitates advancements in risk stratification to optimize treatment outcomes and improve the quality life for patients. Despite its favorable prognosis compared HPV-negative OPSCC, current clinical staging biomarkers, such as p16 status, are limited their ability distinguish between high- low-risk patients within HPV-associated OPSCC. This limitation results overtreatment patients, exposing them unnecessary toxicity, undertreatment high-risk who require more aggressive interventions. review critically evaluates methods, including assessments, de-escalation trials, candidate molecular biomarkers stratification. Emerging approaches immune markers, viral genomic integration patterns, other markers offer promising avenues enhanced prognostic accuracy. By integrating advanced tailored may one day be developed balance oncologic efficacy with reduced treatment-related morbidity. underscores need continued research into predictive adaptive strategies better address diverse profiles OPSCC

Language: Английский

---

Molecular Insights into HR-HPV and HCMV Co-Presence in Cervical Cancer Development

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 582 - 582

Published: Feb. 8, 2025

Cervical cancer remains a significant health concern worldwide and the primary cause of cancerous cervical lesions is infection with high-risk human papillomavirus (HR-HPV). However, emerging evidence suggests that HR-HPV alone insufficient for development, other co-factors may contribute to carcinogenesis. Human cytomegalovirus (HCMV), common herpesvirus frequently detected in samples, has demonstrated oncogenic potential. This review aims explore molecular interactions between HCMV promoting progression. A comprehensive search was conducted PubMed Google Scholar, focusing on articles examining role tissues and/or cells, selected based relevance significance. The reviewed literature indicates share several mechanisms could drive cell transformation. Both viruses synergistically promote epithelial transformation tumor progression multiple ways. facilitate entry by increasing host receptors essential viral attachment. Additionally, cooperatively disrupt cellular processes, enhancing also modulate local immune environment, enabling evasion lesion persistence. further vitro vivo studies are required validate these hypotheses.

Language: Английский

---

The Vaginal Virome in Women’s Health and Disease

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 431 - 431

Published: Feb. 16, 2025

Most research on the vaginal microbiome has focused bacterial communities (the bacteriome), but viruses, including eukaryotic viruses and bacteriophages, are also important players in health disease states. In this review, we will briefly discuss microbiome, delve into what is known about virome its impact women's health, finish with novel microbial or microbial-derived therapeutics horizon. More studies needed to better prevent treat gynecological, reproductive, neonatal diseases.

Language: Английский

---

Unlocking the Interactions Between the Whole-Body Microbiome and HPV Infection: A Literature Review

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 293 - 293

Published: March 18, 2025

The human microbiome plays a vital role in maintaining homeostasis, acting as key regulator of host immunity and defense mechanisms. However, dysbiotic microbial communities may cause disruption the symbiotic relationship between local microbiota, leading to pathogenesis various diseases, including viral infections cancers. One most common infectious agents causing cancer is papilloma virus (HPV), which accounts for more than 90% cervical In cases, immune system activated clears HPV, whereas some infection persists can lead precancerous lesions. Over last two decades, advent next-generation sequencing (NGS) technology bioinformatics has allowed thorough in-depth analysis composition anatomical niches, allowing researchers unveil interactions underlying mechanisms through microbiota could affect HPV establishment, persistence, progression. Accordingly, present narrative review aims shed light on our understanding context its progression, mainly cancer. Furthermore, we explore by balance exert potential pathogenic or protective effects, either persistence disease outcomes clearance. Special interest given how modulate infection. Lastly, summarize latest findings therapeutic efficacy probiotics prebiotics preventing and/or treating vaginal transplantation while highlighting significance personalized medicine approaches emerging from NGS-based profiling artificial intelligence (AI) optimal management HPV-related diseases.

Language: Английский

---

Analysis of 19,116 cases of human papillomavirus infection and subtype distribution in Sanmen, Zhejiang Province, China

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

To analyze the prevalence and subtype distribution of human papillomavirus (HPV) infection in Sanmen County, Zhejiang Province, China, correlation between ThinPrep cytologic test (TCT) results. A retrospective analysis was conducted on demographic clinical data patients who underwent HPV typing TCT at People's Hospital from January 2020 to December 2022. The rate region calculated, status among different age groups departments compared, as well relationship types total 19,116 were included study. overall 16.3%, single-type accounted for 82.7% multiple-type 17.3%, with a high-risk type 12.6% low-risk 2.7%. top six positive cases 52 24.3%, 58 13.4%, 53 12.5%, 81 9.0%, 16 7.3%, 68 5.8%. results revealed significant difference rates groups, < 25-year group having highest 21.1%. proportion abnormal 8.0%, there no comparison high-grade squamous intraepithelial lesions found group. had positivity lesion is mainly single-type. most common 52, 58, 53, High-grade closely related infections 16, 18.

Language: Английский

---

Hallmarks of Bacterial Vaginosis

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1090 - 1090

Published: April 25, 2025

Background: Bacterial vaginosis (BV) is considered the most common cause of vaginal discharge, which related to several public health issues, such as an increased risk for sexually transmitted infections, pelvic inflammatory disease, pregnancy-related problems abortion, stillbirth or premature birth, and tubal factor infertility. BV not infection but imbalance in microbiota, characterized by a substitution normal Lactobacilli flora anaerobe. Reducing resistance against infections mechanisms, including bacterial homeostasis, stabilization acid pH, inhibition pathogens adhesion polyamine degradation, production anti-inflammatory molecules, surfactants, antimicrobial substances like hydrogen peroxide, acids, bacteriocins. Approximately half women with can experience symptoms, mainly include malodor, fishy stinging sensation, pH. The treatment based primarily on promoting restoration eliminating dangerous microbiota antibiotic therapy. However, there high rate recurrence relapse. Objective: Based current literature, this review aims propose list ten hallmarks: dysbiosis, inflammation, apoptosis, pH basification, mucosal barrier integrity, pathway activation, epithelial damage, genomic instability, oxidative stress (OS), metabolic reconfiguration. Conclusions: Understanding causes pathogenicity mechanisms critical preventing improving therapeutic management patients.

Language: Английский

---

Bagging the role of herbal drugs in the management of cervical cancer

Ayush journal of integrative oncology., Journal Year: 2025, Volume and Issue: 2(1), P. 35 - 43

Published: Jan. 1, 2025

Abstract Cervical cancer remains a significant public health concern, ranking as the fourth most common among women worldwide and major contributor to cancer-related mortality, particularly in low- middle-income countries. Despite advancements screening programs that have reduced its incidence industrialized nations, cervical highly prevalent developing regions due inadequate human papillomavirus (HPV) follow-up measures. In India, accounts for substantial proportion of new cases, emphasizing urgent need improved preventive strategies. HPV, primary etiological agent, is sexually transmitted infection, with various risk factors such early sexual activity, multiple partners, immunosuppression playing crucial role transmission. This review highlights global burden cancer, impact HPV challenges associated prevention detection, underscoring enhanced initiatives.

Language: Английский

---

Atypical HPV Typing: Detection of Genital-Associated HPV Type 6 in Verruca Vulgaris of the Hands and Feet in an HIV-Positive Patient

International Medical Case Reports Journal, Journal Year: 2025, Volume and Issue: Volume 18, P. 67 - 74

Published: Jan. 1, 2025

Abstract: Verruca vulgaris is a cutaneous infection predominantly caused by human papillomavirus (HPV) type 1, 2, and 4. In immunocompromised individuals infected with immunodeficiency virus (HIV) infection, HPV leads to higher prevalence of infections also has greater likelihood being atypical types such as genital-associated in extragenital sites. This case report describes 48-year-old male patient who presented skin-colored verrucous papules on the hands feet, no evidence genital lesions. Polymerase Chain Reaction (PCR) genotyping identified presence 4, 6, 16 an etiology verruca vulgaris, low-risk lesions, high-risk HPV. result may suggest failure immune defense system body. Therefore, accurately identifying through PCR testing patients essential for appropriate clinical management monitoring. Keywords: virus, genotyping, polymerase chain reaction

Language: Английский

---