The Effectiveness of COVID‐19 Vaccination on Post‐Acute Sequelae of SARS‐CoV‐2 Infection Among Geriatric Patients DOI
Yap‐Hang Chan,

Chia‐Chen Chen,

Yan Tu

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(12)

Published: Dec. 1, 2024

ABSTRACT This study aims to evaluate the effectiveness of anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines in preventing post‐acute sequelae SARS‐CoV‐2 infection (PASC), commonly known as long COVID, and reducing all‐cause mortality among older patients. A retrospective cohort was conducted using TriNetX database. The consisted patients (age ≥ 65 years) with their first COVID‐19 illness between January 1, 2022, May 31, 2024. Participants were divided into vaccinated unvaccinated groups based on vaccination status. Propensity score matching (PSM) used balance baseline characteristics. Cox regression models log‐rank tests applied estimate hazard ratio (HR) for PASC during 30–180 days follow‐up. included 189 059 geriatric who contracted SARS‐CoV‐2, 5615 183 444 unvaccinated. After PSM, each group contained Vaccinated exhibited a significantly lower incidence symptoms (HR = 0.852, 95% CI: 0.778–0.933, p 0.0005), particularly anxiety depression, HR 0.710 (95% 0.575–0.878, 0.0015). Vaccination also associated reduced 0.231, 0.136–0.394, < 0.0001). findings highlight mitigating development decreasing

Language: Английский

Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis DOI Creative Commons
Liwei Huang, Huamin Li, Bei He

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Since its emergence in 2019, COVID-19 has continued to pose significant threats both the physical and mental health of global population, as well healthcare systems worldwide (Raman et al., Eur Heart J 43:1157–1172, 2022). Emerging evidence indicates that may lead post-acute syndrome (PACS) with cardiovascular implications, potentially driven by factors such ACE2 interaction viruses, systemic inflammation, endothelial dysfunction. However, there remains a limited amount research on manifestations PACS, which delay development optimal treatment strategies for affected patients. Therefore, it is crucial investigate prevalence sequelae patients determine whether infection acts an independent risk factor these outcomes. This meta-analysis adhered PRISMA guidelines was registered PROSPERO (CRD42024524290). A systematic search PubMed, Embase, Cochrane Library conducted up March 17, 2024. The primary outcomes included hypertension, palpitations, chest pain, pooled effect estimate reported proportions odds ratios (ORs) 95% confidence intervals (CIs). Sensitivity subgroup analysis were performed assess robustness results identify sources heterogeneity. total 37 studies, encompassing 2,965,467 patients, analysis. Pooled from case–control studies revealed that, compared control group, ORs pain group 4.0 (95% CI: 1.6, 10.0). palpitation hypertension 3.4 1.1, 10.2) 1.7 1.8), respectively. PACS experiencing palpitation, 22% 14%, 33%), 18% 13%, 24%), 19% 12%, 31%), Our findings indicate 15% experience sequelae. Furthermore, significantly increases likelihood developing uninfected individuals. Future should prioritize investigating underlying pathological mechanisms targeted preventive management strategies. CRD42024524290.

Language: Английский

Citations

1
Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity DOI Creative Commons

Quanzhong Ren,

Xiaotong Xu, Zheng Dong

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

The prevalence of acute lower respiratory infections in individuals with iron deficiency (ID) has significantly increased, and is correlated reduced numbers immune cells impaired function. Dendritic (DCs) play a crucial role combating the influenza A virus (IAV) by initiating adaptive responses. However, impact ID on DCs their response to IAV infection remain unclear. This study showed that impairs antigen-presenting ability DCs, thereby hindering capacity mediate T-cell proliferation clear viruses. restrictive effects begin bone marrow specifically affect monocyte DC progenitor (MDP) stage. reduction number MDPs compromised potential lead decrease population functionality subsequent common precursor (CDP) stage blood, spleen, lungs. highlights previously unrecognized provides valuable insights into cell responses application supplementation fight against viral infections.

Language: Английский

Citations

0
High Prevalence of Long COVID in Common Variable Immunodeficiency: An Italian Multicentric Study DOI Creative Commons

Annalisa Villa,

Cinzia Milito, Carla Maria Deiana

et al.

Journal of Clinical Immunology, Journal Year: 2024, Volume and Issue: 44(2)

Published: Feb. 1, 2024

The long-term effects of SARS-CoV-2 infection represent a relevant global health problem. Long COVID (LC) is defined as complex signs and symptoms developed during or after lasting > 12 weeks. In common variable immunodeficiency (CVID) patients, we previously reported higher risk hospitalization death infection, well prolonged swab positivity frequent reinfections. aim the present study was to assess LC in an Italian cohort CVID patients. We used translated version survey proposed by Centers for Disease Control Prevention (CDC) collect data on LC. enrolled 175 found high prevalence (65.7%). most were fatigue (75.7%), arthralgia/myalgia (48.7%), dyspnea (41.7%). majority patients (60%) experienced symptoms, at least 6 months infection. multivariate analysis, presence complicated phenotype (OR 2.44, 95% CI 1.88-5.03; p = 0.015), obesity 11.17, 1.37-90.95; 0.024), female sex 2.06, 1.09-3.89; 0.024) significantly correlated with development conclusion, this multicenter observational study, demonstrated that increased when compared general population. Improved awareness could optimize management new alarming complication

Language: Английский

Citations

1
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish.

Language: Английский

Citations

1
Short-Term Outcomes in Patients With Coexistence of COVID-19 Infection and Vitamin D Deficiency: A Large Cohort Study DOI Open Access
Yap‐Hang Chan,

Chia‐Chen Chen,

Jheng‐Yan Wu

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Vitamin D deficiency (VDD) is prevalent worldwide and may influence the severity of infectious diseases, including COVID-19. This study aimed to evaluate association between VDD 30-day clinical outcomes in patients with

Language: Английский

Citations

1
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Abstract The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish. Here we generate deficient loaded C57BL/6J mice feeding low high diets, with on normal diet representing controls. All were infected primary omicron XXB SARS-CoV-2 isolate lung inflammatory responses analyzed histology, immunohistochemistry RNA-Seq. Compared controls, showed no significant changes in viral loads or histopathology, whereas, slightly, but significantly, reduced histopathology. Transcriptional modest, illustrated widespread dysregulation signatures for both vs. Some these could be associated detrimental outcomes, whereas others would viewed as beneficial. Diet-associated thus induced modest modulations signatures, histopathologically detectable exacerbations. Author summary can lead anemia, problem worldwide. excessive less common, consumption supplements. We investigate herein using mouse model, whether diets predispose outcomes lungs after infection SARS-CoV-2. promote inflammation. However, found, modulations, unaffected slightly reduced, histopathology was either indicated disease. These findings do not support view that represent comorbidities predisposing overt COVID-19

Language: Английский

Citations

0
The Effectiveness of COVID‐19 Vaccination on Post‐Acute Sequelae of SARS‐CoV‐2 Infection Among Geriatric Patients DOI
Yap‐Hang Chan,

Chia‐Chen Chen,

Yan Tu

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(12)

Published: Dec. 1, 2024

ABSTRACT This study aims to evaluate the effectiveness of anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines in preventing post‐acute sequelae SARS‐CoV‐2 infection (PASC), commonly known as long COVID, and reducing all‐cause mortality among older patients. A retrospective cohort was conducted using TriNetX database. The consisted patients (age ≥ 65 years) with their first COVID‐19 illness between January 1, 2022, May 31, 2024. Participants were divided into vaccinated unvaccinated groups based on vaccination status. Propensity score matching (PSM) used balance baseline characteristics. Cox regression models log‐rank tests applied estimate hazard ratio (HR) for PASC during 30–180 days follow‐up. included 189 059 geriatric who contracted SARS‐CoV‐2, 5615 183 444 unvaccinated. After PSM, each group contained Vaccinated exhibited a significantly lower incidence symptoms (HR = 0.852, 95% CI: 0.778–0.933, p 0.0005), particularly anxiety depression, HR 0.710 (95% 0.575–0.878, 0.0015). Vaccination also associated reduced 0.231, 0.136–0.394, < 0.0001). findings highlight mitigating development decreasing

Language: Английский

Citations

0