Causal associations between severe COVID-19 and diseases of seven organs: a proteome-wide mendelian randomization study DOI Creative Commons
Yunhang Shen, Yi Zhang, Yeyang Xu

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

The coronavirus disease 2019 (COVID-19) pandemic poses an enormous threat to public health worldwide. Many retrospective studies and case reports date have shown associations between severe COVID-19 diseases of multi-organs. However, the research on causal mechanisms behind this phenomenon is neither extensive nor comprehensive. We conducted a proteome-wide Mendelian randomization (MR) study using summary statistics from Genome-Wide Association Studies (GWAS) related seven organs: lung, spleen, liver, heart, kidney, testis, thyroid, based European ancestry. primary analytical method used radial inverse variance-weighted (radial IVW) method, supplemented with (IVW), weighted-median (WM), MR-Egger methods. Our findings confirmed association multiple organ-related diseases, such as Hypothyroidism, strict autoimmune (HTCBSA), Thyroid disorders (TD), Graves’ (GD). And we also identified certain proteins that are associated Superoxide Dismutase 2 (SOD2) TEK Receptor Tyrosine Kinase (TEK), which considered potential drug targets. Phenotype scanning sensitivity analyses were implemented consolidate results for randomization. This provides compelling foundation investigating caused in future studies.

Language: Английский

Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study DOI Creative Commons
Lihua Huang, Min Xiao, Huang Xiao-ling

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 20, 2025

Objective This research aimed to analyze the impact of hemorrhagic fever with renal syndrome (HFRS) acute pancreatitis (AP) on severity and prognosis patients, screen risk factors HFRS AP, establish a nomogram model.

Language: Английский

Citations

1
Causal Relationship between Gut Microbiota, Plasma Metabolites, and Acute Pancreatitis: An Exploratory Mendelian Randomization Study DOI
Qingqiang Ni, Huimin Zhang, Zhengjian Wang

et al.

Published: Jan. 1, 2025

Background: Emerging evidence suggests a significant correlation between pancreatitis and gut microbiota, yet the causal relationship underlying mechanism remain largely undetermined. Given that microbiota plays crucial role in regulating circulating metabolites, we aimed to elucidate how these interactions impact risk of acute (AP).Methods: Using two-sample Mendelian randomization (MR) analysis, investigated links among plasma AP. Enrichment analysis was performed determine primary metabolite classes metabolic pathways associated with AP risk.Findings: The MR revealed 18 microbial taxa 59 metabolites effects on Furthermore, mediation identified seven as potential intermediaries pathway from AP, emphasizing critical carbohydrate metabolism via polyol fructolysis, well lipid homeostasis, disease's pathogenesis.Interpretation: Our systematic study provided comprehensive characterization causally novel mediating microbiota's effect risk. These findings provide new insights into microbiome-related signatures influencing suggest targets for future research intervention.Funding: This supported by Shandong Provincial Natural Science Foundation (Grant/Award Number: ZR2019PH070) Taishan Scholars Program Province China tsqn202306374).Declaration Interest: authors declare no competing interests.Ethical Approval: Ethical approval informed consent participants were acquired each cohort enrolled original GWAS studies, accordance their local regulations institute requirements. All this study, based summary-level data publicly available databases, require further ethical permit.

Language: Английский

Citations

0
Causal associations between COVID-19 and diseases of seven organs: A proteome-wide Mendelian randomization study DOI Creative Commons
Yunhang Shen, Yi Zhang, Yeyang Xu

et al.

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: May 25, 2024

The coronavirus disease 2019 (COVID-19) pandemic poses an enormous threat to public health worldwide. Many retrospective studies and case reports date have shown associations between severe COVID-19 multi-organs. However, the research on causal mechanisms behind this phenomenon is neither extensive nor comprehensive. We conducted a proteome-wide Mendelian randomization (MR) study using summary statistics from genome-wide association (GWAS) of diseases related seven organs: lung, spleen, liver, heart, kidney, testis, thyroid, based European ancestry. filtered data multi-organ proteomic autopsies cases previous studies. primary analytical method used radial inverse variance-weighted (radial IVW) method, supplemented with (IVW), weighted-median (WM), MR-Egger methods. Our findings confirmed multiple organ-related diseases, such as Hypothyroidism, strict autoimmune (HTCBSA), Thyroid disorders (TD), Graves’ (GD). we did not find correlations certain that been clinically established. And we’ve also identified some proteins are associated disease.

Language: Английский

Citations

0
Causal associations between severe COVID-19 and diseases of seven organs: a proteome-wide mendelian randomization study DOI Creative Commons
Yunhang Shen, Yi Zhang, Yeyang Xu

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

The coronavirus disease 2019 (COVID-19) pandemic poses an enormous threat to public health worldwide. Many retrospective studies and case reports date have shown associations between severe COVID-19 diseases of multi-organs. However, the research on causal mechanisms behind this phenomenon is neither extensive nor comprehensive. We conducted a proteome-wide Mendelian randomization (MR) study using summary statistics from Genome-Wide Association Studies (GWAS) related seven organs: lung, spleen, liver, heart, kidney, testis, thyroid, based European ancestry. primary analytical method used radial inverse variance-weighted (radial IVW) method, supplemented with (IVW), weighted-median (WM), MR-Egger methods. Our findings confirmed association multiple organ-related diseases, such as Hypothyroidism, strict autoimmune (HTCBSA), Thyroid disorders (TD), Graves’ (GD). And we also identified certain proteins that are associated Superoxide Dismutase 2 (SOD2) TEK Receptor Tyrosine Kinase (TEK), which considered potential drug targets. Phenotype scanning sensitivity analyses were implemented consolidate results for randomization. This provides compelling foundation investigating caused in future studies.

Language: Английский

Citations

0