A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 24, 2025

Abstract In the past, drug research and development has predominantly followed a "single target, single disease" model. However, clinical data show that single-target drugs are difficult to interfere with complete disease network, prone develop resistance low safety in use. The proposal of multi-target therapy (also known as "cocktail therapy") provides new approach for discovery, which can affect reduce adverse reactions by regulating multiple targets. Natural products an important source innovative development, more than half approved small molecule related natural products. there many challenges process products, such active screening, target identification preclinical dosage optimization. Therefore, how good from always been challenge. This article summarizes applications shortcomings technologies product bioactivity clarify mode action (direct/indirect target), dose Moreover, response faced trend interdisciplinary multi-technology integration, strategy "active substances — optimization" is proposed solve key dimensions levels.

Language: Английский

The modulation of proteomics and antioxidant stress is involved in the effect of nitazoxanide against Japanese encephalitis virus in vitro

Veterinary Microbiology, Journal Year: 2024, Volume and Issue: 298, P. 110289 - 110289

Published: Oct. 24, 2024

Language: Английский