A Hidden Guardian: The Stability and Spectrum of Antibody-Dependent Cell-Mediated Cytotoxicity in COVID-19 Response in Chinese Adults DOI Creative Commons
Jinge Cao, Mengze Gan, Zhihao Zhang

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 262 - 262

Published: Feb. 28, 2025

Objectives: Identifying immune-protective biomarkers is crucial for the effective management and mitigation of current future COVID-19 outbreaks, particularly in preventing or counteracting immune evasion exhibited by Omicron variants. The emergence SARS-CoV-2 variants, especially those within lineage, has highlighted their capacity to evade neutralizing antibodies, emphasizing need understand role antibody-dependent cell-mediated cytotoxicity (ADCC) combating these infections. Methods: This study, conducted Qichun City, Hubei province, from December 2021 March 2023, involved 50 healthy Chinese adults who had received two doses inactivated vaccines subsequently experienced mild infections with BA.5 variant. Blood samples were collected at six distinct time points: baseline 1st, 3rd, 6th, 9th months following third dose vaccine, as well 3 post-breakthrough infection. Their sera analyzed assess ADCC neutralization effects. Results: results indicated that antibodies elicited vaccine targeted spike protein, exhibiting both pre-existing activities against variants XBB.1.5. Notably, activity demonstrated greater stability compared effects, persisting least 15 post-vaccination, could be augmented additional breakthrough effect associated hybrid immunity effectively targets a spectrum prospective including BA.2.86, CH.1.1, EG.5.1, JN.1. Conclusions: In light its broad-spectrum efficacy, we recommend use biomarker assessing protective guiding development monoclonal antibodies.

Language: Английский

A Hidden Guardian: The Stability and Spectrum of Antibody-Dependent Cell-Mediated Cytotoxicity in COVID-19 Response in Chinese Adults DOI Creative Commons
Jinge Cao, Mengze Gan, Zhihao Zhang

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 262 - 262

Published: Feb. 28, 2025

Objectives: Identifying immune-protective biomarkers is crucial for the effective management and mitigation of current future COVID-19 outbreaks, particularly in preventing or counteracting immune evasion exhibited by Omicron variants. The emergence SARS-CoV-2 variants, especially those within lineage, has highlighted their capacity to evade neutralizing antibodies, emphasizing need understand role antibody-dependent cell-mediated cytotoxicity (ADCC) combating these infections. Methods: This study, conducted Qichun City, Hubei province, from December 2021 March 2023, involved 50 healthy Chinese adults who had received two doses inactivated vaccines subsequently experienced mild infections with BA.5 variant. Blood samples were collected at six distinct time points: baseline 1st, 3rd, 6th, 9th months following third dose vaccine, as well 3 post-breakthrough infection. Their sera analyzed assess ADCC neutralization effects. Results: results indicated that antibodies elicited vaccine targeted spike protein, exhibiting both pre-existing activities against variants XBB.1.5. Notably, activity demonstrated greater stability compared effects, persisting least 15 post-vaccination, could be augmented additional breakthrough effect associated hybrid immunity effectively targets a spectrum prospective including BA.2.86, CH.1.1, EG.5.1, JN.1. Conclusions: In light its broad-spectrum efficacy, we recommend use biomarker assessing protective guiding development monoclonal antibodies.

Language: Английский

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