Intentions of healthcare seeking and self-isolation for MPOX among men who have sex with men in China: a national cross-sectional study DOI Creative Commons
Fangfang Chen, Peilong Li, Weiming Tang

et al.

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: May 7, 2024

Linking identified MPOX cases to care is essential for control. This study aims investigate the intentions of healthcare seeking and self-isolation among men who have sex with (MSM) in China. A cross-sectional online survey was conducted early August 2023 Respondents were recruited by community-based organizations (CBOs), collecting information on demographics, health status, behavioural psychological characteristics. Univariate multivariate logistic regression analyses performed examine predictors seek self-isolate within MSM population. total 7725 participants recruited, a median age 30 years. 92.21% would MPOX-like symptoms, but only 52.50% intended if diagnosed. Intentions lower those symptoms past 3 months (standardized prevalence ratio (SPRs) = 0.82, 95% CI: 0.74-0.89) willingness reduced diagnosed (SPRs 0.65, 0.48-0.87). Participants free sexually transmitted infections (STIs) aware their HIV status more likely than STIs or unaware status. Regular followers perceiving low risk infection inclined take preventive measures. These findings highlight need targeted prevention strategies high-risk groups importance addressing barriers infectious disease response.

Language: Английский

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics DOI Creative Commons
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Niclosamide, initially developed as an anthelmintic, has recently emerged a potential antiviral, showing efficacy against diverse viral threats, including Mpox. As the global health landscape faces recurrent Mpox outbreaks, repurposing niclosamide through advanced material strategies offers promising therapeutic avenues. This article explores antiviral mechanisms of niclosamide, focusing on how innovative nano‐hybrid formulations enhance its bioavailability and pharmacological performance. By leveraging nanohybridization, niclosamide's limitations—such poor solubility bioavailability—are addressed, enabling targeted delivery sustained release. Early preclinical studies reveal that disrupts replication entry processes, suggesting utility option poxvirus infections. Looking forward, further in vitro, animal models, clinical investigations are essential to optimize application dosing for With continued development materials, nanohybrid could become critical tool managing related offering accessible, cost‐effective outbreak preparedness.

Language: Английский

Citations

0
Intentions of healthcare seeking and self-isolation for MPOX among men who have sex with men in China: a national cross-sectional study DOI Creative Commons
Fangfang Chen, Peilong Li, Weiming Tang

et al.

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: May 7, 2024

Linking identified MPOX cases to care is essential for control. This study aims investigate the intentions of healthcare seeking and self-isolation among men who have sex with (MSM) in China. A cross-sectional online survey was conducted early August 2023 Respondents were recruited by community-based organizations (CBOs), collecting information on demographics, health status, behavioural psychological characteristics. Univariate multivariate logistic regression analyses performed examine predictors seek self-isolate within MSM population. total 7725 participants recruited, a median age 30 years. 92.21% would MPOX-like symptoms, but only 52.50% intended if diagnosed. Intentions lower those symptoms past 3 months (standardized prevalence ratio (SPRs) = 0.82, 95% CI: 0.74-0.89) willingness reduced diagnosed (SPRs 0.65, 0.48-0.87). Participants free sexually transmitted infections (STIs) aware their HIV status more likely than STIs or unaware status. Regular followers perceiving low risk infection inclined take preventive measures. These findings highlight need targeted prevention strategies high-risk groups importance addressing barriers infectious disease response.

Language: Английский

Citations

1