Rapid, Sensitive, and Species-Independent Detection of Crimean Congo Hemorrhagic Fever Virus Nucleoprotein and GP38 Antibodies DOI
Elif Karaaslan, Cheng‐Feng Chiang,

Gülter Öncü Kurutaş

et al.

Published: Jan. 1, 2024

Language: Английский

Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda DOI Creative Commons
Evan A. Mihalakakos, Victor Ssempijja, Ruy M. Ribeiro

et al.

Emerging Microbes & Infections, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease endemic to many regions of Africa, the Middle East, Southeast Asia and Balkans. Caused by CCHF virus (CCHFV), has been recognized cause illness in Uganda since 1950s recently, more intensive surveillance suggests CCHFV widely within country. Most focused on Ugandan cattle corridor due risk exposure associated with livestock practices. Here we evaluated seroprevalence several Southern communities outside combined longitudinal sample sets measure immune response for up decade. Interestingly, across three community types, agrarian, trading fishing, detected all but found highest fishing communities. We also measured consistent CCHFV-specific antibody responses Our findings support conclusion that highlight additional may be at exposure.

Language: Английский

Citations

0
Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) DOI Creative Commons

Paloma Kiwan,

Morena Gasparine,

Dorine Decarreaux

et al.

One Health, Journal Year: 2025, Volume and Issue: unknown, P. 101020 - 101020

Published: March 1, 2025

The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen known to cause severe viral fever. We aimed evaluate the potential circulation of CCHFV in Corsica through serosurvey, including anonymized residual sera (RS) and high-risk individuals exposed animals and/or tick bites due occupational activities. This cross-sectional study involved two groups: RS from medical biology laboratories (slaughterhouse workers, veterinary professionals, animal farmers, rangers) collected across during 2022-2023. Antibodies targeting nucleoprotein were detected using double-antigen ELISA. ELISA-positive samples underwent neutralizing antibody testing. Sociodemographic epidemiological data structured questionnaire group. Total anti-CCHFV seropositivity was 0.08 % (n = 2) [95 Confidence Interval (CI): 0.06-0.09] 0.50 1) CI: 0.43-0.56] groups (p < 0.01). Lifetime tick-bites reported by 65.9 118) respondents, with higher rates among farmers (Odds Ratio (OR) 3.4; 95 CI 1.4-8.5) participants >10 years exposure (OR 3.8; 1.7-8.5). provides initial evidence human Corsica, consistent those observed other Western European regions. Our results indicate risk CCHF Corsican population, particularly slaughterhouse workers. Continuous surveillance public education are essential mitigate this risk, especially these targeted healthcare ensuring prompt diagnosis prevention outbreaks.

Language: Английский

Citations

0
The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean–Congo Hemorrhagic Fever Virus (CCHFV) DOI Creative Commons

Aysegul Pirincal,

Mehmet Ziya Doymaz

Viruses, Journal Year: 2024, Volume and Issue: 16(10), P. 1547 - 1547

Published: Sept. 30, 2024

Crimean-Congo hemorrhagic fever virus (CCHFV) is an

Language: Английский

Citations

1
Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice DOI Creative Commons

Shanna Leventhal,

Carl Shaia, Deepashri Rao

et al.

npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 19, 2024

Language: Английский

Citations

1
Rapid, Sensitive, and Species-Independent Detection of Crimean Congo Hemorrhagic Fever Virus Nucleoprotein and GP38 Antibodies DOI
Elif Karaaslan, Cheng‐Feng Chiang,

Gülter Öncü Kurutaş

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0