The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection DOI Creative Commons
Omer Qutaiba B. Allela,

Mohamad Ghazanfari Hashemi,

Shirin Heidari

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 19, 2024

The Flaviviridae family includes the dengue virus (DENV). About half of world's population is in danger because estimated 390 million infections and 96 symptomatic cases that occur each year. An effective treatment for fever (DF) does not yet exist. Therefore, a better knowledge how viral proteins virus-targeted medicines may exert distinct functions depending on exact cellular region addressed aid creating much-needed antiviral medications. Lipids facilitate coordination many replication phases, from entrance to dissemination. In addition, flaviviruses masterfully plan significant rearrangement host cell's lipid metabolism foster growth new viruses. Recent research has consistently shown significance certain classes flavivirus infections. For instance, DENV-infected cells, overall cholesterol (CHO) levels are only little altered, DENV significantly reduced when CHO inhibited. Moreover, statins decrease serotype 2 (DENV-2) titers, indicating prerequisite cycle. Furthermore, Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors now being evaluated human research. A pharmacological target management high PCSK9. suppression PCSK9 been proposed as possible defense against DENV. Numerous studies have generally recommended use lipid-lowering medications suppress As result, we investigated popular techniques this We also examined metabolism, lipids, receptors affect regulation. Lastly, looked at different This article discusses method's future based its benefits drawbacks.

Language: Английский

The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection DOI Creative Commons
Omer Qutaiba B. Allela,

Mohamad Ghazanfari Hashemi,

Shirin Heidari

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 19, 2024

The Flaviviridae family includes the dengue virus (DENV). About half of world's population is in danger because estimated 390 million infections and 96 symptomatic cases that occur each year. An effective treatment for fever (DF) does not yet exist. Therefore, a better knowledge how viral proteins virus-targeted medicines may exert distinct functions depending on exact cellular region addressed aid creating much-needed antiviral medications. Lipids facilitate coordination many replication phases, from entrance to dissemination. In addition, flaviviruses masterfully plan significant rearrangement host cell's lipid metabolism foster growth new viruses. Recent research has consistently shown significance certain classes flavivirus infections. For instance, DENV-infected cells, overall cholesterol (CHO) levels are only little altered, DENV significantly reduced when CHO inhibited. Moreover, statins decrease serotype 2 (DENV-2) titers, indicating prerequisite cycle. Furthermore, Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors now being evaluated human research. A pharmacological target management high PCSK9. suppression PCSK9 been proposed as possible defense against DENV. Numerous studies have generally recommended use lipid-lowering medications suppress As result, we investigated popular techniques this We also examined metabolism, lipids, receptors affect regulation. Lastly, looked at different This article discusses method's future based its benefits drawbacks.

Language: Английский

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