From active affordance to active inference: vertical integration of cognition in the cerebral cortex through dual subcortical control systems DOI

Phan Luu,

Don M. Tucker, Karl Friston

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 2, 2023

In previous papers, we proposed that the dorsal attention system's top-down control is regulated by division of limbic system, providing a feedforward or impulsive form generating expectancies during active inference. contrast, ventral system division, regulating feedback constraints and error-correction for inference within neocortical hierarchy. Here, propose these forms cognitive reflect vertical integration subcortical arousal systems evolved specific behavior control. The impetus to action phasic arousal, mediated lemnothalamic projections from reticular activating lower brainstem, then elaborated hippocampus division. constraint-based on environmental requirements-is tonic activation furnished collothalamic midbrain centers, sustained amygdala, basal ganglia, an evolutionary-developmental analysis, understanding differing affordance-for motor vertebrate neuraxis-may help explain evolution cognition expectancy mammalian 6-layered neocortex.

Language: Английский

Crym-positive striatal astrocytes gate perseverative behaviour DOI Creative Commons

Matthias Ollivier,

Joselyn S. Soto, Kay E. Linker

et al.

Nature, Journal Year: 2024, Volume and Issue: 627(8003), P. 358 - 366

Published: Feb. 28, 2024

Abstract Astrocytes are heterogeneous glial cells of the central nervous system 1–3 . However, physiological relevance astrocyte diversity for neural circuits and behaviour remains unclear. Here we show that a specific population astrocytes in striatum expresses μ-crystallin (encoded by Crym mice CRYM humans) is associated with several human diseases, including neuropsychiatric disorders 4–7 In adult mice, reducing levels striatal through CRISPR–Cas9-mediated knockout resulted perseverative behaviours, increased fast synaptic excitation medium spiny neurons dysfunctional excitatory–inhibitory balance. Increased perseveration stemmed from loss astrocyte-gated control neurotransmitter release presynaptic terminals orbitofrontal cortex–striatum projections. We found could be remedied using inhibitory chemogenetics 8 , this treatment also corrected deficits. Together, our findings reveal converging molecular, synaptic, circuit behavioural mechanisms which molecularly defined allocated gates phenotypes accompany 9–12 Our data -positive have key biological functions within system, uncover astrocyte–neuron interaction targeted treatments perseveration.

Language: Английский

Citations

19
Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration DOI
Jinbin Xu,

Huifangjie L. Farsad,

Yiran Hou

et al.

Nature Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 9, 2023

Language: Английский

Citations

24
The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra DOI Creative Commons
Margaret I. Davis, Jill R. Crittenden,

Austin Y. Feng

et al.

PLoS ONE, Journal Year: 2018, Volume and Issue: 13(2), P. e0191436 - e0191436

Published: Feb. 21, 2018

Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum substantia nigra, where they play a role in learning control of motivated actions. However, pattern CB1-R expression across different striatal compartments, microcircuits efferent targets, contribution CB1-R-expressing neurons this pattern, unclear. We use combination conventional techniques novel genetic models evaluate striosome (patch) matrix compartments striatum, nigral targets medium spiny projection (MSNs). protein mRNA follow descending dorsolateral-to-ventromedial intensity gradient caudal with elevated striosomes relative surrounding matrix. The lateral predominance contrasts that classical striosomal marker, mu opioid receptor (MOR), which is most prominently rostromedial striosomes. similar Drd2 dopamine immunoreactivity opposite Substance P. This topology maintained downstream globus pallidus nigra. Dense striatonigral fibers extend dorsally within nigra pars reticulata, colocalize bundles ventrally extending, striosome-targeted, dendrites dopamine-containing compacta (striosome-dendron bouquets). Within fluorescently labeled MSN collaterals Cre recombinase-mediated deletion from cortical or MSNs, MSN-selective reintroduction knockout mice, demonstrate principal source dorsolateral local collaterals. These data suggest for striosome-dendron bouquet projections anatomically poised mediate presynaptic disinhibition both MSNs midbrain response endocannabinoids cannabinomimetics.

Language: Английский

Citations

74
Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model DOI Creative Commons

Alexander Friedman,

Emily Hueske,

Sabrina M. Drammis

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(4), P. 918 - 934.e49

Published: Oct. 27, 2020

Language: Английский

Citations

47
Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice DOI Creative Commons
Allain-Thibeault Le Sourd Ferhat,

Elisabeth Verpy,

Anne Biton

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: March 16, 2023

Autism is characterized by atypical social communication and stereotyped behaviors. Mutations in the gene encoding synaptic scaffolding protein SHANK3 are detected 1–2% of patients with autism intellectual disability, but mechanisms underpinning symptoms remain largely unknown. Here, we behavior Shank3 Δ11/Δ11 mice from 3 to 12 months age. We observed decreased locomotor activity, increased self-grooming modification socio-sexual interaction compared wild-type littermates. then used RNAseq on four brain regions same animals identify differentially expressed genes (DEGs). DEGs were identified mainly striatum associated transmission (e.g., Grm2, Dlgap1 ), G-protein-signaling pathways Gnal , Prkcg1 Camk2g as well excitation/inhibition balance Gad2 ). Downregulated upregulated enriched clusters medium-sized spiny neurons expressing dopamine 1 (D1-MSN) 2 receptor (D2-MSN), respectively. Several ( Cnr1 Drd4 ) reported striosome markers. By studying distribution glutamate decarboxylase GAD65, encoded showed that compartment was enlarged displayed much higher expression GAD65 mice. Altogether, these results indicate altered -deficient strongly suggest, for first time, excessive related an imbalance striatal matrix compartments.

Language: Английский

Citations

16
Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders DOI Creative Commons
Joshua L. Plotkin, Joshua A. Goldberg

The Neuroscientist, Journal Year: 2018, Volume and Issue: 25(4), P. 359 - 379

Published: Oct. 31, 2018

The basal ganglia are an intricately connected assembly of subcortical nuclei, forming the core adaptive network connecting cortical and thalamic circuits. For nearly three decades, researchers medical practitioners have conceptualized how circuit works, its pathology underlies motor disorders such as Parkinson’s Huntington’s diseases, using what is often referred to “box-and-arrow model”: a diagram showing broad strokes connectivity pathological increases decreases in weights specific connections that occur disease. While this model still has great utility led groundbreaking strategies treat disorders, our evolving knowledge function made it clear classic several shortcomings severely limit predictive descriptive abilities. In review, we will focus on striatum, main input nucleus ganglia. We describe recent advances understanding rich microcircuitry plastic capabilities factors not captured by original box-and-arrow model, provide examples inform current pathologies underlying disorders.

Language: Английский

Citations

46
Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons DOI Creative Commons
Eric M. Prager, Daniel B. Dormán, Zachary Hobel

et al.

Neuron, Journal Year: 2020, Volume and Issue: 108(6), P. 1091 - 1102.e5

Published: Oct. 19, 2020

Language: Английский

Citations

39
New roles for dopamine in motor skill acquisition: lessons from primates, rodents, and songbirds DOI
Alynda N. Wood

Journal of Neurophysiology, Journal Year: 2021, Volume and Issue: 125(6), P. 2361 - 2374

Published: May 12, 2021

Motor learning is a core aspect of human life and appears to be ubiquitous throughout the animal kingdom. Dopamine, neuromodulator with multifaceted role in synaptic plasticity, may key signaling molecule for motor skill learning. Though typically studied context reward-based associative learning, dopamine necessary some types Mesencephalic structures are highly conserved among vertebrates, as their primary targets within basal ganglia, subcortical circuit important control. With focus on benefits cross-species comparisons, this review examines how "model-free" "model-based" computational frameworks understanding dopamine's applied The hypotheses that could drive either by functioning reward prediction error, through passive facilitating normal ganglia activity, or other mechanisms examined light new studies using humans, rodents, songbirds. Additionally, paradigms enhance our bridging gap between theoretical literature humans species discussed.

Language: Английский

Citations

29
Striatal circuit development and its alterations in Huntington's disease DOI Creative Commons

Margaux Lebouc,

Quentin Richard, Maurice Garret

et al.

Neurobiology of Disease, Journal Year: 2020, Volume and Issue: 145, P. 105076 - 105076

Published: Sept. 6, 2020

Huntington's disease (HD) is an inherited neurodegenerative disorder that usually starts during midlife with progressive alterations of motor and cognitive functions. The caused by a CAG repeat expansion within the huntingtin gene leading to severe striatal neurodegeneration. Recent studies conducted on pre-HD children highlight early developmental starting as soon 6 years old, earliest age assessed. These findings, in line data from mouse models HD, raise questions when development do first disease-related emerge whether they contribute later appearance features disease. In this review we will describe different stages network then discuss recent evidence for its rodent We argue better understanding striatum's should help assessing aberrant neurodevelopmental processes linked HD mutation.

Language: Английский

Citations

30
From Progenitors to Progeny: Shaping Striatal Circuit Development and Function DOI Creative Commons

Rhys Knowles,

Nathalie Dehorter, Tommas J. Ellender

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(46), P. 9483 - 9502

Published: Nov. 17, 2021

Understanding how neurons of the striatum are formed and integrate into complex synaptic circuits is essential to provide insight striatal function in health disease. In this review, we summarize our current understanding development associated with a focus on their embryonic origin. Specifically, address role distinct types progenitors, found proliferative zones ganglionic eminences ventral telencephalon, generation diverse interneurons projection neurons. Indeed, recent evidence would suggest that progenitor origin dictates key characteristics postnatal cells, including neurochemical content, location within striatum, long-range inputs. We also observations regarding progenitors cortical other regions discuss might inform future research eminences. Last, examine dysfunction can alter formation, as exemplified Huntington's disease autism spectrum disorder, increased have significant implications for directions improved therapeutic options. SIGNIFICANCE STATEMENT This review highlights recently defined novel roles cells shaping functional properties both striatum. It outlines developmental mechanisms guide neuronal from progeny Where questions remain open, cortex present possible avenues research. progenitor-centric perspective onto disorder. investigations manipulations clinical settings will likely require careful consideration great intrinsic diversity neurogenic potential.

Language: Английский

Citations

25