Open Chemistry,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 1, 2024
Abstract
The
sixth
most
common
cancer
in
the
world,
esophageal
cancer,
requires
aggressive
treatment
such
as
surgery,
chemotherapy,
radiotherapy,
and
immunotherapy.
Phytochemicals
medicinal
plants
are
being
used
green
synthesis
of
nanoparticles.
Our
study
aimed
to
synthesize
ZnO–SnO
2
nerolidol
nanocomposite
its
effects
on
squamous
cell
carcinoma
cells.
UV
spectroscopy
showed
significant
absorbance
at
288
nm,
transmission
electron
microscopy
DLS
spherical
shapes,
also
108
nm
average
diameters.
was
investigated
using
energy-dispersive
X-ray
analysis,
Fourier
transform
infrared
spectroscopy,
photoluminescence,
field
emission
scanning
microscopy.
A
cytotoxic
effect
observed
against
KYSE-150
cells
with
an
IC
50
concentration
14.9
μg/mL.
inhibited
proliferation
enhanced
apoptosis
by
altering
mitochondrial
membrane
potential.
oxidative
stress,
leading
a
decrease
superoxide
dismutase,
catalase,
glutathione
increase
lipid
peroxidation.
Ultimately,
caspase
cascade
inducing
caspases
3,
8,
9
On
whole,
we
suggest
that
can
be
effective
strategy
However,
understanding
molecular
circuits
is
still
warranted.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(4)
Published: Feb. 3, 2024
In
recent
years,
the
development
of
dual
dopant‐based
nanoparticles
(NPs)
has
gained
significant
attention
as
they
possess
exceptional
physico‐chemical
and
biomedical
properties,
making
them
potential
candidates
for
antimicrobial
anticancer
uses.
this
research,
we
successfully
synthesized
nickel
oxide
(NiO)
copper,
manganese‐doped
NiO
(CuMn:NiO)
NPs
using
a
green
synthesis
method.
The
process
involved
Trigonella
foenum‐graecum
(
T.f.graecum
)
leaves
extract
nucleating
agent.
were
confirmed
by
various
studies.
Based
on
X‐ray
diffraction
analysis,
median
size
was
determined
36
nm
32
CuMn:NiO
NPs.
antibacterial
study
revealed
that
exhibited
higher
zone
inhibition
in
contrast
to
both
Gram‐positive
Streptococcus
pneumoniae
,
Bacillus
subtilis
megaterium
Gram‐negative
bacteria
Klebsiella
Escherichia
coli
Vibrio
cholerae
compared
with
commercial
amoxicillin.
antifungal
studies
conducted
against
Candida
albicans
demonstrated
enhanced
efficacy
comparison
vitro
testing
human
breast
cancer
cells
(MCF‐7)
NPs,
supported
IC
50
concentrations
11
9
μg/mL,
respectively.
photoluminescence
(PL)
spectra
emission
at
508
518
nm,
respectively,
which
indicated
generation
active
free
radicals
These
findings
suggest
hold
promise
healthcare
industry.
Biotechnology and Applied Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
ABSTRACT
Obesity,
modifiable
and
an
avertable
medical
condition,
has
become
a
global
threat
due
to
rapid
modernization
industrialization.
Swift
growth
in
not
only
eases
the
day‐to‐day
life,
it
also
mandates
sedentary
lifestyle,
which
leads
various
noncommunicable
diseases.
At
present
one
eight
people
population
are
obese,
these
booming
obese
individuals
prone
other
micro‐
macrovascular
diseases
such
hyperglycemia,
myocardial
infraction,
hypertension,
stroke,
so
forth.
Ample
research
had
unveiled
intricate
association
perceived
between
obesity
Type
2
diabetes
mellitus
pathogenesis.
Although
intake
of
anti‐obesity
drugs
along
with
anti‐diabetic
effectively
regulated
hyperglycemic
conditions
diabetic
patients,
causes
side
effects
on
long‐term
usage.
Coumarins
phytochemicals
that
have
demonstrated
pharmacological
properties
including
anti‐inflammatory,
antioxidant,
anti‐tumor,
In
this
analysis,
we
assessed
potency
aesculetin,
courmarin
derivative.
The
rats
were
induced
high‐fat
diet
subjected
streptozotocin
infusion
induce
hyperglycemia.
Obese
treated
aesculetin
for
its
effect.
BMI
analyze
effect
aesculetin.
Diabetic
profile
test
lipid
performed
evaluate
Ameliorative
during
was
renal
test,
hepatic
function
biomarkers,
by
histopathological
analysis
cardiac
tissue.
anti‐inflammatory
antioxidant
property
determine
mechanism
action
To
confirm
adipokines
levels
estimated.
Aesculetin
eminently
decreased
BMI,
HbA1c,
cholesterol
levels,
intensified
secretion
insulin
rats.
It
renal,
functional
markers
prevented
tissue
injury
adipokines,
increased
antioxidants,
level
proinflammatory
cytokines,
thereby
obesity‐induced
conclude,
our
findings
confirmed
supplementary
prevents
disorder
Catalysts,
Journal Year:
2025,
Volume and Issue:
15(3), P. 283 - 283
Published: March 17, 2025
The
polyol
method
under
a
single
pot
has
successfully
produced
coating
of
CuO,
TiO2,
and
the
combination
CuO/TiO2
around
Ag
NWs
sequential
addition.
their
with
pure
metal
oxide
hybrid
were
characterized
using
X-ray
diffraction
(XRD),
scanning
electron
microscopy
(SEM)
coupled
EDX,
photoelectron
spectroscopy
(XPS),
UV–Visible,
photoluminescent
(PL)
spectroscopy,
cyclic
voltammetry
(CV).
formation
ultra-thin
was
also
been
seen
in
presence
TiO2
coating.
co-axial
each
form
preserved
SPR
demonstrated
photon
harvesting
from
400–800
nm
range.
band
gap
hybridization
confirmed
by
CV
for
Ag@CuO/TiO2
design,
which
made
structure
reliable
catalyst.
Therefore,
material
expresses
excellent
photocatalytic
activities
carcinogenic
textile
dyes
such
as
turquoise
blue
(TB),
sapphire
(SB),
methyl
orange
(MO),
without
reagent
H2O2.
(i.e.,
Ag@CuO/TiO2)
exhibited
degradation
within
6
min
Additionally,
showed
antibacterial
against
various
bacteria
(Pseudomonas
aeruginosa,
Escherichia
coli,
Staphylococcus
aureus,
Bacillus
subtilis,
pumilus)
when
assayed
broth
media.
materials
have
established
degrading
disinfection
roles
suitable
environmental
perspectives.
role
texture
further
improved
growth
NWs.
preparatory
route
possibly
ensued
metal–metal
metal–hybrid
Schottky
junctions,
would
expectedly
transform
it
into
diode
electronic
applications.
Biotechnology and Applied Biochemistry,
Journal Year:
2024,
Volume and Issue:
71(4), P. 779 - 790
Published: March 12, 2024
Abstract
Supramolecular
nanoparticles
containing
peptides
and
drugs
have
recently
gained
recognition
as
an
effective
tumor
treatment
drug
delivery
system.
A
multitarget
termed
pemetrexed
is
against
various
cancers,
including
nonsmall
cell
lung
cancer.
The
work
aims
to
establish
the
capability
of
gold
(PEM‐AuNPs)
induce
apoptosis
explore
molecular
changes.
X‐ray
diffraction,
Fourier‐transform
infrared
spectroscopy,
ultraviolet–visible
scanning
electron
microscope,
transmission
microscope
were
used
investigate
synthesized
nanoparticles.
MTT
assay
was
utilized
anticancer
properties
PEM‐AuNPs
at
varying
concentrations
(50,
100,
200
µM).
demonstrated
a
decrease
in
viability
with
55.87%,
43.04%,
25.59%
for
A549
cells
54.31%,
37.40%,
25.84%
H1299
respective
concentrations.
To
assess
perform
morphological
analysis,
diverse
biochemical
staining
techniques,
acridine
orange‐ethidium
bromide
4′,6‐diamidino‐2‐phenylindole
nuclear
assays,
employed.
Additionally,
2′,7′‐dichlorofluorescein
diacetate
confirmed
induction
reactive
oxygen
species
generation,
while
JC‐1
validated
impact
on
mitochondrial
membrane
IC
50
concentration
PEM‐AuNPs.
Thus,
study
that
exhibited
enhanced
activity
both
cells.
Biotechnology and Applied Biochemistry,
Journal Year:
2024,
Volume and Issue:
71(4), P. 896 - 908
Published: April 9, 2024
Abstract
Gefitinib
(GET)
is
a
revolutionary
targeted
treatment
inhibiting
the
epidermal
growth
factor
receptor's
tyrosine
kinase
action
by
competitively
ATP
binding
site.
In
preclinical
trials,
several
lung
cancer
cell
lines
and
xenografts
have
demonstrated
potential
activity
with
GET.
Response
rates
neared
25%
in
trials
for
non‐small
cancer.
Here,
we
describe
one‐pot
synthesis
of
GET@ZIF‐8
nanocomposites
(NCs)
pure
water,
encapsulating
zeolitic
imidazolate
framework
8
(ZIF‐8).
This
method
developed
NCs
consistent
morphology
loading
efficiency
9%,
resulting
capacity
20
wt%.
Cell
proliferation
assay
assessed
anticancer
effect
on
A549
H1299
cells.
The
different
biochemical
staining
(Calcein‐AM
PI
4′,6‐Diamidino‐2‐phenylindole
nuclear
staining)
assays
death
morphological
examination.
Additionally,
mode
apoptosis
was
evaluated
mitochondrial
membrane
(∆
ψ
m)
reactive
oxygen
species.
Therefore,
study
concludes
that
are
pledged
to
treat
