Variations in adverse events associated with different infusion modalities of parenteral nutrition: A pharmacovigilance study DOI
Jing Zhou,

Zhengli Jiang,

Ying Su

et al.

Journal of Parenteral and Enteral Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Background Parenteral nutrition can be administered through various infusion modalities. However, limited research has examined the differences in adverse reactions associated with these Methods Data from Food and Drug Administration event reporting system database were analyzed using disproportionality analysis to identify compare signals across different Results A total of 1642 reports related parenteral included: 356 all‐in‐one group, 85 two‐in‐one 1086 fat emulsion 115 amino acid supplementation group. Across all reports, 4159 preferred terms identified, distributed as follows: 858 152 2975 174 events spanning 20 organ classes. In top three lymphangitis, increased blood magnesium, incorrect drug administration rate. leading fungemia, extravasation, disease complications. most significant included overload syndrome, fatty deficiency, nutrition–associated liver disease. key impaired glucose tolerance, hyperglycemia, elevated hepatic enzymes. Conclusion This study identified variations These findings underscore need for tailored interventions ensure safe effective use nutrition, thereby optimizing therapeutic outcomes clinical practice.

Language: Английский

Variations in adverse events associated with different infusion modalities of parenteral nutrition: A pharmacovigilance study DOI
Jing Zhou,

Zhengli Jiang,

Ying Su

et al.

Journal of Parenteral and Enteral Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Background Parenteral nutrition can be administered through various infusion modalities. However, limited research has examined the differences in adverse reactions associated with these Methods Data from Food and Drug Administration event reporting system database were analyzed using disproportionality analysis to identify compare signals across different Results A total of 1642 reports related parenteral included: 356 all‐in‐one group, 85 two‐in‐one 1086 fat emulsion 115 amino acid supplementation group. Across all reports, 4159 preferred terms identified, distributed as follows: 858 152 2975 174 events spanning 20 organ classes. In top three lymphangitis, increased blood magnesium, incorrect drug administration rate. leading fungemia, extravasation, disease complications. most significant included overload syndrome, fatty deficiency, nutrition–associated liver disease. key impaired glucose tolerance, hyperglycemia, elevated hepatic enzymes. Conclusion This study identified variations These findings underscore need for tailored interventions ensure safe effective use nutrition, thereby optimizing therapeutic outcomes clinical practice.

Language: Английский

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