Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus—A Comprehensive Review of Clinical Studies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7299 - 7299

Published: July 2, 2024

Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes (T1DM), focusing on cellular molecular mechanisms derived from interplay oral microbiota host immune response. A comprehensive search of studies published 2008 2023 was conducted elucidate association these two diseases. Preclinical clinical evidence suggests relationship, individuals T1DM exhibiting heightened susceptibility periodontitis, vice versa. The includes recent findings human studies, revealing variations in composition patients, including increases certain pathogenic species such as

Language: Английский

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Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Published: April 15, 2024

Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes (T1DM), focusing on cellular molecular mechanisms derived interplay oral microbiota host immune response. A comprehensive search of literature published 2008 2023 was conducted elucidate association these two diseases. Preclinical clinical evidence suggests relationship, individuals T1DM exhibiting heightened susceptibility periodontitis, vice versa. The includes recent findings from human studies, revealing variations in composition patients, including increases certain pathogenic species such as Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, along shifts microbial diversity abundance. Molecular underlying this involve oxidative stress dysregulated responses, mediated inflammatory cytokines IL-6, IL-8, MMPs. Furthermore, disruptions bone turnover markers, RANKL OPG, contribute periodontal complications patients. While preventive measures manage patients may improve overall health outcomes, further research is needed understand intricate interactions microbiota, response, disease, systemic population.

Language: Английский

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Type 1 Diabetes Mellitus and Host-Bacterial Interactions in the Oral Cavity

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2024, Volume and Issue: 36, P. 100536 - 100536

Published: June 13, 2024

Type 1 diabetes mellitus (T1DM) is an autoimmune disease which characterized by the destruction of insulin producing pancreatic β-cells. Current evidence supports contribution T-cells, macrophages, B-cells, and dendritic cells to pathogenesis T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions environmental factors create dysbiotic environment oral cavity, support growth pathogenic microbial biofilms. Changes composition, together with diminished lead development two most common diseases, caries periodontal diseases. In present review, we summarized current on manifestations T1DM, described shifts composition response.

Language: Английский

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Probiotics Support Resilience of the Oral Microbiota during Resolution after Experimental Gingivitis—A Randomized, Double-Blinded, Placebo-Controlled Trial

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4805 - 4805

Published: Nov. 16, 2023

The present study aims to test whether probiotics protect against experimental gingivitis incited by 14 days of oral hygiene neglect and/or subsequently support the restoration homeostasis. Eighty systemically and orally healthy participants refrained from procedures for days, followed with regular procedures. Additionally, consumed either (n = 40) or placebo throughout trial. At baseline, day 14, 28, supragingival plaque score bleeding-on-probing percentage (BOP %) were registered, saliva samples collected. microbiota was characterized using 16S sequencing, analyzed levels pro-inflammatory cytokines proteases. relative abundance Lautropia (p 0.014), Prevotella 0.046), Fusobacterium 0.033), Selenomonas 0.0078) genera significantly higher in group compared group, while Rothia 0.047) species associated group. Streptococcus sanguinis Campylobacter gracilis No difference observed salivary cytokines, albumin, any enzyme activity. suggests that resilience resolution period after gingivitis.

Language: Английский

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Probiotics Partly Suppress the Impact of Sugar Stress on the Oral Microbiota—A Randomized, Double-Blinded, Placebo-Controlled Trial

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4810 - 4810

Published: Nov. 17, 2023

The aim was to test if probiotics counteract oral dysbiosis during 14 days of sugar stress and subsequently help restore homeostasis. Eighty healthy individuals received either (n = 40) or placebo lozenges for 28 rinsed with a 10% sucrose solution 6-8 times the initial trial. Saliva supragingival samples were collected at baseline, day 14, 28. analyzed levels pro-inflammatory cytokines, albumin, salivary enzyme activity. microbiota characterized according Human Oral Microbiome Database. After stress, relative abundance Porphyromonas species significantly higher (p 0.03) remained elevated in probiotic group compared 0.004). At 28, Kingella 0.03). Streptococcus gordinii Neisseria elongata associated on while sobrinus On albumin level lower group. present study demonstrates potential stabilizing effect mediated by consumption short-term stress.

Language: Английский

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