A Gastrodia elata polysaccharide for restoring intestinal immunocompromise

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141781 - 141781

Published: March 1, 2025

We here extracted a polysaccharide fragment from Gastrodia elata, characterized by main chain connected via (1 → 4)-α-D-Glcp bonds, with terminal α-D-Glcp-(1→) linked to the through O-6 of 4,6)-α-D-Glcp and O-3 3,4)-α-D-Glcp (SRGP). Both in vitro vivo experiments demonstrated that SRGP activates TLR4/NF-κB signaling pathway, exerting immunomodulatory effects alleviating cyclophosphamide (CTX)-induced intestinal mucosal damage mice. High-throughput 16S rRNA sequencing further revealed restores gut microbiota composition enhances abundance specific bacterial populations. Additionally, improves CTX-induced upregulating tight junction proteins, mitigating dysbiosis, regulating both overall microbial community levels bacteria.

Language: Английский

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ShenJiaoLingCao Decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119830 - 119830

Published: April 1, 2025

Language: Английский

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Unusual polyunsaturated fatty acids in edible marine worms identified by covalent adduct chemical ionization mass spectrometry

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141287 - 141287

Published: Sept. 13, 2024

Language: Английский

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Shenjiaolingcao Decoction Ameliorate Cyclophosphamide-Induced Splenic Injury and Immunosuppression Via the Inhibition of Mapk/Mek/Erk Signaling Pathway Activity and Modulation of Amino Acid Metabolism

Published: Jan. 1, 2024

Language: Английский

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