Synthesis of low-cost and eco-friendly hard carbon material anodes for potassium-ion batteries using pre-hydrolysate

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: 13(2), P. 115455 - 115455

Published: Jan. 18, 2025

Language: Английский

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A Comprehensive Review of Instrumentation and Applications in Post‐Column and In‐Source Derivatization for LC‐MS

Mass Spectrometry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

ABSTRACT Liquid chromatography‐mass spectrometry (LC‐MS) has become an indispensable tool for elucidating molecular structures and quantifying diverse compounds within complex mixtures. Despite its versatility, it faces various challenges such as ion suppression, low sensitivity, analyte instability, matrix effects, which are being overcome by different kinds of offline online derivatization techniques to improve specificity reduce potential interferences. In this context, considerable advancements have been made in reviewing critically evaluating a wide range developed methods techniques; however, little attention given post‐column (PCD) LC‐MS. Therefore, comprehensive review highlights state‐of‐the‐art LC‐MS with specific focus on types chemical physical PCD, in‐source derivatization. It also examines the latest instrumentation developments, influencing factors, explores applications food, proteomics, biology, pharmaceuticals, environmental analysis from past four decades. Besides, role PCD along outlining advantages disadvantages. Furthermore, special emphasis is prospects insights developing more versatile LC‐PCD‐MS methodologies, address ongoing aim open new research avenues analysts.

Language: Английский

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Advancements in Electrochemical Biosensors for Comprehensive Glycosylation Assessment of Biotherapeutics

Sensors, Journal Year: 2025, Volume and Issue: 25(7), P. 2064 - 2064

Published: March 26, 2025

Proteins represent a significant portion of the global therapeutics market, surpassing hundreds billions dollars annually. Among various post-translational modifications, glycosylation plays crucial role in influencing protein structure, stability, and function. This modification is especially important biotherapeutics, where precise characterization glycans vital for ensuring product efficacy safety. Although mass spectrometry-based techniques have become essential tools glycomic analysis due to their high sensitivity resolution, complexity lengthy processing times limit practical application. In contrast, electrochemical methods provide rapid, cost-effective, sensitive alternative assessment, enabling real-time glycan structures on biotherapeutic proteins. These techniques, often used conjunction with complementary methods, offer valuable insights into profiles both isolated glycoproteins intact cells. review examines latest advancements biosensors analysis, highlighting potential enhancing biotherapeutics advancing field precision medicine.

Language: Английский

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Current research on determination of medically valued stilbenes and stilbenoids from spruce and pine with chromatographic and spectrometric methods—A review

Journal of Chromatography Open, Journal Year: 2024, Volume and Issue: 6, P. 100169 - 100169

Published: Aug. 9, 2024

The review compiles a selection of the recently published chemical research on stilbenes, stilbene glucuronides, and stilbenoids. basic structure group compounds is 1,2-diphenylethene. They can be isolated from spruce, pine, other conifers, specifically wood bark, needles, heartwood, roots. Stilbenes stilbenoids possess antioxidative, anti-inflammatory, antimicrobial impacts what for they are used in pharmaceuticals. decrease glucose triglyceride concentrations plasma. Especially, treatment cancer, liver injuries, Alzheimer's disease. Lately, extraction materials was done with alcohol, water, or nonpolar solvents. Moreover, were extracted supercritical fluid hot water methods. Rectified extracts studied liquid and/or gas chromatography. Mass spectrometry negative electrospray ionization prevalent method their identification. HPLC-MS methods preferred over GC to identify dimeric stilbenes oligomeric

Language: Английский

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Hydrophilic interaction chromatographic evaluation of zwitterionic polymer grafted silica gel via multiple binding sites

Journal of Separation Science, Journal Year: 2024, Volume and Issue: 47(14)

Published: July 1, 2024

A novel zwitterionic polymer grafted silica stationary phase, Sil-PZIC, was prepared by bonding poly(ethylene maleic anhydride) molecules on the surface of via multiple binding sites, followed ammonolysis anhydride through a nucleophilic substitution reaction with ethylenediamine. The phase characterized solid-state

Language: Английский

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