Preparation of Chiral Stationary Phase Co‐Modified With Homochiral Secondary Amine Molecular Cages and Amylose and Its Enantiomeric Separation Performance DOI
Shanshan Sun,

Dekuan Hu,

Xiaoge Wang

et al.

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(4)

Published: April 1, 2025

In this study, reduced porous organic cages with homochiral secondary amine structure were immobilized on a silica gel surface, and derivative of 3,5-dimethyl phenyl carbamate amylose was coated onto the molecular cage-modified sphere to prepare chiral stationary phase co-modified cages. The prepared characterized using techniques such as scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis. results confirmed successful preparation phase. 10 compounds selected systematically evaluate enantioselective performance new normal-phase chromatography for enantiomeric separation. experimental demonstrated that well separated phase, complete separation achieved trans-stilbene oxide, phenylethanol, 1-phenyl-1-propanol, all showing resolution greater than 1.5. contrast, showed only partial these compounds. study highlights synergistic effect in enhancing separation, demonstrating their significant potential development phases.

Language: Английский

Preparation of Chiral Stationary Phase Co‐Modified With Homochiral Secondary Amine Molecular Cages and Amylose and Its Enantiomeric Separation Performance DOI
Shanshan Sun,

Dekuan Hu,

Xiaoge Wang

et al.

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(4)

Published: April 1, 2025

In this study, reduced porous organic cages with homochiral secondary amine structure were immobilized on a silica gel surface, and derivative of 3,5-dimethyl phenyl carbamate amylose was coated onto the molecular cage-modified sphere to prepare chiral stationary phase co-modified cages. The prepared characterized using techniques such as scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis. results confirmed successful preparation phase. 10 compounds selected systematically evaluate enantioselective performance new normal-phase chromatography for enantiomeric separation. experimental demonstrated that well separated phase, complete separation achieved trans-stilbene oxide, phenylethanol, 1-phenyl-1-propanol, all showing resolution greater than 1.5. contrast, showed only partial these compounds. study highlights synergistic effect in enhancing separation, demonstrating their significant potential development phases.

Language: Английский

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