Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance DOI Creative Commons
Jing Cai, Fang Wang,

Shengjun Shi

et al.

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 41(1)

Published: Dec. 11, 2024

The dysregulation of microRNA (miRNA) expression contributes to the development allergic rhinitis (AR). This study investigates serum miR-135a levels and their association with regulatory T cell (Treg) helper 17 (Th17) balance in AR patients. A total 93 patients 76 healthy controls were retrospectively recruited. Levels miR-135a, peripheral blood Th17 Treg cells, Treg/Th17-related cytokines measured. We assessed diagnostic value for its relationship Treg/Th17 balance. showed significantly elevated immunoglobulin E (IgE), IL-17 IL-6 levels, alongside reduced IL-10, TGF-β1, ratios. ≤0.536 demonstrated potential AR. Patients higher displayed increased level ratios, cell, lower nasal symptom score (TNSS). Serum negatively correlated TNSS, IL-17, IL-6, percentages, positively Collectively, decreased are associated balance, supporting as a biomarker diagnosis.

Language: Английский

Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance DOI Creative Commons
Jing Cai, Fang Wang,

Shengjun Shi

et al.

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 41(1)

Published: Dec. 11, 2024

The dysregulation of microRNA (miRNA) expression contributes to the development allergic rhinitis (AR). This study investigates serum miR-135a levels and their association with regulatory T cell (Treg) helper 17 (Th17) balance in AR patients. A total 93 patients 76 healthy controls were retrospectively recruited. Levels miR-135a, peripheral blood Th17 Treg cells, Treg/Th17-related cytokines measured. We assessed diagnostic value for its relationship Treg/Th17 balance. showed significantly elevated immunoglobulin E (IgE), IL-17 IL-6 levels, alongside reduced IL-10, TGF-β1, ratios. ≤0.536 demonstrated potential AR. Patients higher displayed increased level ratios, cell, lower nasal symptom score (TNSS). Serum negatively correlated TNSS, IL-17, IL-6, percentages, positively Collectively, decreased are associated balance, supporting as a biomarker diagnosis.

Language: Английский

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