Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair after myocardial infarction

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 335, P. 216 - 236

Published: May 19, 2021

Language: Английский

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Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction

Bioactive Materials, Journal Year: 2020, Volume and Issue: 6(2), P. 520 - 528

Published: Sept. 11, 2020

Myocardial infarction (MI) is one of cardiovascular diseases that pose a serious threat to human health. The pathophysiology MI complex and contains several sequential phases including blockage coronary artery, necrosis myocardial cells, inflammation, fibrosis. Aiming at the treatment different stages MI, in this work, an injectable alginate based composite hydrogel developed load vascular endothelial active factor (VEGF) silk fibroin (SF) microspheres containing bone morphogenetic protein 9 (BMP9) for releasing VEGF BMP9 realize their respective functions. results vitro experiments indicate rapid initial release during first few days relatively slow sustained days, facilitating formation blood vessels early stage inhibiting fibrosis long-term stage, respectively. Intramyocardial injection such into infarct border zone mice model via multiple points promotes angiogenesis reduces size. Taken together, these dual-release from collaborative effect on improvement heart function, showing promising potential cardiac clinical application.

Language: Английский

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Preparation of a recombinant collagen-peptide (RHC)-conjugated chitosan thermosensitive hydrogel for wound healing

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 119, P. 111555 - 111555

Published: Sept. 29, 2020

Language: Английский

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Innervation: the missing link for biofabricated tissues and organs

npj Regenerative Medicine, Journal Year: 2020, Volume and Issue: 5(1)

Published: June 5, 2020

Abstract Innervation plays a pivotal role as driver of tissue and organ development well means for their functional control modulation. Therefore, innervation should be carefully considered throughout the process biofabrication engineered tissues organs. Unfortunately, has generally been overlooked in most non-neural engineering applications, part due to intrinsic complexity building organs containing heterogeneous native cell types structures. To achieve proper organs, specific host axon populations typically need precisely driven appropriate location(s) within construct, often over long distances. As such, neural and/or guidance strategies necessary adjunct organogenesis endeavors across multiple systems. address this challenge, our team is actively axon-based “living scaffolds” that may physically wire during bioreactors serve substrate effectively drive targeted long-distance growth integration axons after implantation. This article reviews neuroanatomy regulation cardiac, skeletal, smooth muscle highlights potential promote biofabricated muscles, use endeavor both vitro vivo applications. We assert included component biofabrication, orchestrate axonal are advantageous ensure function, tolerance, assimilation, bio-regulation with recipient post-implant.

Language: Английский

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Advances in biomedical applications of self-healing hydrogels

Materials Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 5(12), P. 4368 - 4400

Published: Jan. 1, 2021

In this paper, various self-healing hydrogels are discussed including their healing mechanisms and details of current biomedical applications.

Language: Английский

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