Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management
Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 21, 2024
Microneedles
(MNs)
have
emerged
as
a
promising
transdermal
antimicrobial
delivery
system,
providing
precise
and
localized
drug
while
complemented
with
noninvasiveness
patient
compliance.
Currently,
the
topical
application
of
antimicrobials
restricts
drugs
to
critical
areas
wound
bed,
largely
due
barriers
posed
by
necrotic
tissue,
scab
formation,
bacterial
biofilms,
which
severely
diminish
bioavailability
therapeutics.
MNs
enabled
efficient
targeted
overcome
many
chronic
challenges.
Over
past
decade,
significant
progress
has
been
made
develop
unique
properties
tailored
for
vaccines,
anticancer,
antimicrobials.
As
ongoing
research
continues
refine
MN
design,
material
properties,
formulations,
potential
revolutionizing
efficacy,
experience,
therapeutic
outcomes
remains
at
forefront
scientific
research.
In
this
review,
insights
are
provided
into
latest
progress,
current
developments,
diverse
applications
delivery.
Herein,
translational
is
highlighted
perspective
on
challenges
associated
clinical
translation
provided.
Furthermore,
review
aids
in
identifying
gaps
empowering
contributing
future
implementation
cutting‐edge
systems
effectively
tackle
resistance.
Language: Английский
3D bioprinted microneedles: merging drug delivery and scaffold science for tissue-specific applications
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(11), P. 1559 - 1572
Published: May 9, 2024
Three-Dimensional
(3D)
microneedles
have
recently
gained
significant
attention
due
to
their
versatility,
biocompatibility,
enhanced
permeation,
and
predictable
behavior.
The
incorporation
of
biological
agents
into
these
3D
constructs
has
advanced
the
traditional
microneedle
an
effective
platform
for
wide-ranging
applications.
Language: Английский
Advances in the development of medical dressings for the treatment of diabetic foot wounds
Ming Cai,
No information about this author
Zhao Liu,
No information about this author
Xun Sun
No information about this author
et al.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
498, P. 155575 - 155575
Published: Sept. 7, 2024
Language: Английский
Emerging strategies for treating medical device and wound‐associated biofilm infections
Microbial Biotechnology,
Journal Year:
2024,
Volume and Issue:
17(10)
Published: Oct. 1, 2024
Bacterial
infections
represent
a
significant
global
threat
to
human
health,
leading
considerable
economic
losses
through
increased
healthcare
costs
and
reduced
productivity.
One
major
challenge
in
treating
these
is
the
presence
of
biofilms
-
structured
bacterial
communities
that
form
protective
barriers,
making
traditional
treatments
less
effective.
Additionally,
rise
antibiotic-resistant
bacteria
has
exacerbated
treatment
difficulties.
To
address
challenges,
researchers
are
developing
exploring
innovative
approaches
combat
biofilm-related
infections.
This
mini-review
highlights
recent
advancements
following
key
areas:
surface
anti-adhesion
technologies,
electricity,
photo/acoustic-active
materials,
endogenous
mimicking
agents,
drug
delivery
systems.
These
strategies
aim
prevent
biofilm
formation,
disrupt
existing
biofilms,
enhance
efficacy
antimicrobial
treatments.
Currently,
show
great
potential
for
applications
medical
fields
such
as
device
wound
associated
By
summarizing
developments,
this
provides
comprehensive
resource
seeking
advance
management
biofilm-associated
Language: Английский
Origami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(9), P. 816 - 816
Published: Aug. 28, 2024
This
review
describes
the
discovery,
structure,
activity,
engineered
constructs,
and
applications
of
KR-12,
smallest
antibacterial
peptide
human
cathelicidin
LL-37,
production
which
can
be
induced
under
sunlight
or
by
vitamin
D.
It
is
a
moonlighting
that
shows
both
antimicrobial
immune-regulatory
effects.
Compared
to
KR-12
extremely
appealing
due
its
small
size,
lack
toxicity,
narrow-spectrum
activity.
Consequently,
various
peptides
have
been
tune
activity
stability
via
amino
acid
substitution,
end
capping,
hybridization,
conjugation,
sidechain
stapling,
backbone
macrocyclization.
We
also
mention
recently
discovered
KR-8
RIK-10
are
shorter
than
KR-12.
Nano-formulation
provides
an
avenue
targeted
delivery,
controlled
release,
increased
bioavailability.
In
addition,
has
covalently
immobilized
on
biomaterials/medical
implants
prevent
biofilm
formation.
These
constructs
with
enhanced
potency
demonstrated
eradicate
drug-resistant
pathogens,
disrupt
preformed
biofilms,
neutralize
endotoxins,
regulate
host
immune
responses.
Also
highlighted
safety
efficacy
these
in
topical
systemic
animal
models.
Finaly,
we
summarize
achievements
discuss
future
developments
as
cosmetic
preservatives,
novel
antibiotics,
anti-inflammatory
peptides,
microbiota-restoring
agents.
Language: Английский
Nanomaterial-Enhanced Microneedles: Emerging Therapies for Diabetes and Obesity
Mehrnaz Abbasi,
No information about this author
Divine Afunu Boka,
No information about this author
Hannah DeLoit
No information about this author
et al.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1344 - 1344
Published: Oct. 21, 2024
Drug
delivery
systems
(DDS)
have
improved
therapeutic
agent
administration
by
enhancing
efficacy
and
patient
compliance
while
minimizing
side
effects.
They
enable
targeted
delivery,
controlled
release,
bioavailability.
Transdermal
drug
(TDDS)
offer
non-invasive
medication
evolved
to
include
methods
such
as
chemical
enhancers,
iontophoresis,
microneedles
(MN),
nanocarriers.
MN
technology
provides
innovative
solutions
for
chronic
metabolic
diseases
like
diabetes
obesity
using
various
types.
For
management,
MNs
continuous
glucose
monitoring,
diabetic
wound
healing,
painless
insulin
delivery.
treatment,
provide
sustained
transdermal
of
anti-obesity
drugs
or
nanoparticles
(NPs).
Hybrid
integrating
wearable
sensors
smart
materials
enhance
treatment
effectiveness
management.
Nanotechnology
has
advanced
nano-scaled
liposomes
polymeric
NPs
with
MNs.
In
glucose-responsive
facilitate
At
the
same
time,
lipid
nanocarriers
in
dissolving
extended
release
stability
absorption
disorder
therapies.
DDS
are
advancing
toward
personalized
treatments
enhanced
nanomaterials.
These
approaches
can
outcomes
through
precise
real-time
monitoring.
However,
widespread
implementation
faces
challenges
ensuring
biocompatibility,
improving
technologies,
scaling
production,
obtaining
regulatory
approval.
This
review
will
present
recent
advances
developing
applying
nanomaterial-enhanced
management
also
discussing
challenges,
limitations,
future
perspectives
these
DDS.
Language: Английский
Versatile nanomaterials used in combatting biofilm infections
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: Jan. 31, 2025
Microbial
infections
are
a
pressing
global
health
issue,
exacerbated
by
the
rise
of
antibiotic-resistant
bacteria
due
to
widespread
antibiotic
overuse.
This
resistance
diminishes
effectiveness
current
treatments,
intensifying
need
for
new
antimicrobial
agents
and
innovative
drug
delivery
strategies.
Nanotechnology
presents
promising
solutions,
leveraging
unique
properties
nanomaterials
such
as
tunable
optical
electronic
characteristics,
nanoscale
size,
high
surface-to-volume
ratios.
These
features
enhance
their
versatile
systems.
minireview
classifies
into
four
categories
based
on
mechanisms
action:
thermal
generation,
reactive
oxygen
species
gas
nanocarrier
systems
liposomes,
polymersomes,
metal-organic
frameworks.
Uniquely,
this
review
integrates
comparative
analysis
these
mechanisms,
highlighting
relative
advantages,
limitations,
applications
across
diverse
microbial
targets.
Additionally,
it
identifies
emerging
trends
in
field,
providing
forward-looking
perspective
how
recent
advancements
nanotechnology
can
be
leveraged
address
unmet
clinical
needs.
Finally,
article
discusses
future
directions
opportunities
nanotechnology.
Language: Английский
A New Insight into Phage Combination Therapeutic Approaches Against Drug-Resistant Mixed Bacterial Infections
PHAGE,
Journal Year:
2024,
Volume and Issue:
5(4), P. 203 - 222
Published: Oct. 17, 2024
Rising
antibiotic
resistance
among
bacterial
pathogens
has
become
a
substantial
health
issue
for
human
civilization.
The
emergence
of
these
in
high-risk
diseases
such
as
cystic
fibrosis
(CF)
led
to
financial
and
nonfinancial
losses,
necessitating
alternative
therapies.
This
study
presents
an
overview
approaches,
including
phage
therapy,
antimicrobial
peptides
(AMPs),
nanotechnology,
monoclonal
antibodies
(mAbs),
microbial
therapies
(probiotic
therapy),
clustered
regularly
interspaced
short
palindromic
repeats
technology
(CRISPR),
aptamers
focusing
on
their
mechanisms
action
exploring
the
impact
combining
derivatives
with
mentioned
approaches.
Although
approaches
combinations
phages
show
promise,
phage-antibiotic
combination
been
subject
most
studies,
It
proven
be
highly
effective
combating
antibiotic-resistant
infections.
Other
also
appear
promising,
but
further
studies
are
needed
determine
effectiveness.
emphasizes
need
more
thorough
research
into
different
treatments
beyond
well-established
strategy.
Language: Английский
The impact of monoclonal antibodies in preventing antimicrobial resistance (AMR)
Raja Chakraverty,
No information about this author
Jyotirmoy Bondyopadhyay,
No information about this author
Tatini Debnath
No information about this author
et al.
Indian Journal of Pharmacy and Pharmacology,
Journal Year:
2024,
Volume and Issue:
11(1), P. 23 - 28
Published: May 7, 2024
Monoclonal
antibodies
(mAbs)
have
transformed
modern
medicine
through
precision
targeting
and
therapeutic
efficacy.
This
summary
summarises
the
development,
applications,
comparative
characteristics
of
mAbs
in
context
antiviral
medicines
antibiotic
treatment
durations.
are
designed
to
target
specific
antigens
with
great
affinity
specificity,
making
them
important
for
diagnostics
treatments.
Anti-virulence
mAbs,
a
type
mAb,
pathogen
virulence
factors
rather
than
pathogens
themselves,
providing
promising
technique
combating
infectious
diseases
while
limiting
resistance
development.
When
comparing
duration
medication
versus
mAb
treatment,
frequently
provide
shorter
more
tailored
regimen.
can
lead
better
patient
outcomes,
less
resistance,
lower
risk
side
effects
associated
long-term
usage.
Antigen
selection,
hybridoma
creation,
antibody
synthesis,
purification,
characterization
all
steps
development
process,
advances
like
recombinant
DNA
technology
improving
efficiency
scalability.
Language: Английский