
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 277 - 277
Published: Jan. 23, 2025
The review explores the potential of asiaticoside-loaded bioscaffolds to improve management hyperglycemic wounds, particularly diabetic foot ulcers (DFUs). Asiaticoside, sourced from Centella asiatica, possesses properties that address DFUs’ healing challenges: insufficient angiogenesis, persistent inflammation, and delayed tissue regeneration. By incorporating asiaticoside into bioscaffold 3D designs including hydrogels, microneedle arrays, nanofibrous meshes, therapeutic efficacy is optimized. This examines mechanisms in wound (collagen production, angiogenesis modulation, inflammation reduction, cell migration proliferation) based on vitro vivo studies. Asiaticoside also demonstrates synergistic abilities with other biomaterials, creating possibility more effective therapies. While preclinical research promising, clinical trials are crucial evaluate safety patients DFUs. Asiaticoside-loaded a significant development may aid treating complications. Their ability offer individualized treatment plans has enhance quality life those who suffer diabetes. thorough literature search (2019–2024) across multiple databases, excluding secondary non-English articles.
Language: Английский