Conceptualization and Preliminary Characterization of Poloxamer-Based Hydrogels for Biomedical Applications DOI Creative Commons
Marta Tuszyńska, Joanna Skopińska-Wiśniewska,

Mateusz Bartniak

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 18, 2025

Poloxamers are widely used in biomedical applications, but their effectiveness depends on achieving an optimal sol-gel phase transition near body temperature. This study evaluates three different poloxamer mixtures for potential treating meniscus tears, focusing gel formation, injectability, and cell compatibility. The rheological properties, cytotoxicity assessments, cellular migration experiments were studied using NIH/3T3 fibroblast cells as the standard experimental model primary research. hydrogels showed properties well suited to injectable or drug delivery systems. Specifically, combination of Synperonic F108 Poloxamer 188 tended show less adhesion more aggregation, followed by a greater number viable cells, suggesting its utility coating foundational matrix. Concurrently, Kolliphor 407 exhibited increased viscosity, maintaining state at physiological Its biocompatibility indicated controlled-release systems musculoskeletal injuries. Our findings demonstrate that concentration composition significantly influence applications. These triblock copolymer useful characteristics surgical such favorable kinetics biocompatibility, applications osteoarticular regeneration.

Language: Английский

Conceptualization and Preliminary Characterization of Poloxamer-Based Hydrogels for Biomedical Applications DOI Creative Commons
Marta Tuszyńska, Joanna Skopińska-Wiśniewska,

Mateusz Bartniak

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 18, 2025

Poloxamers are widely used in biomedical applications, but their effectiveness depends on achieving an optimal sol-gel phase transition near body temperature. This study evaluates three different poloxamer mixtures for potential treating meniscus tears, focusing gel formation, injectability, and cell compatibility. The rheological properties, cytotoxicity assessments, cellular migration experiments were studied using NIH/3T3 fibroblast cells as the standard experimental model primary research. hydrogels showed properties well suited to injectable or drug delivery systems. Specifically, combination of Synperonic F108 Poloxamer 188 tended show less adhesion more aggregation, followed by a greater number viable cells, suggesting its utility coating foundational matrix. Concurrently, Kolliphor 407 exhibited increased viscosity, maintaining state at physiological Its biocompatibility indicated controlled-release systems musculoskeletal injuries. Our findings demonstrate that concentration composition significantly influence applications. These triblock copolymer useful characteristics surgical such favorable kinetics biocompatibility, applications osteoarticular regeneration.

Language: Английский

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