Gradually-frozen aligned bacterial nanocellulose membranes loaded with gallic acid exhibit enhanced mechanical and dual antithrombotic-antimicrobial properties

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Bacterial nanocellulose (BNC) is a versatile natural polymer with unique morphological properties. However, its susceptibility to biofouling limits utility in healthcare. To address this challenge, study explores the incorporation of gallic acid, phenolic acid potent antimicrobial and antithrombotic properties, into BNC membranes. Additionally, novel drying method termed gradual freezing introduced, resulting directionally-aligned membrane enhanced mechanical integrity high porosity. Using glycerol as solvent plasticizer, was loaded air-dried (AD-BNC), freeze-dried (FD-BNC), gradually-frozen (GF-BNC) Successful drug-loading FD-BNC GF-BNC significantly increased elasticity films, however testing indicated that acid/glycerol counterpart (GF-GG-BNC) achieved overall optimal strength elasticity. These samples were selected for further antifouling testing. Antibacterial assays demonstrated practical efficacy GF-GG-BNC inhibiting proliferation biofilm formation E. coli S. aureus, while favorable behaviour prevented clot red blood cell adhesion on material's surface when compared findings highlight potential multifunctional biomaterial prevention biomedical applications.

Language: Английский

Living electronics in cellulose zoogleal mats

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: unknown, P. 100627 - 100627

Published: Dec. 1, 2024

Language: Английский