Development of Electroconductive Polypyrrole‐Polycaprolactone and Poly(3,4‐Ethylenedioxythiophene)‐poly(Styrenesulfonate)‐Polyethylene Oxide Fibrous Scaffolds by Pressurised Gyration for Cardiac Tissue Engineering Applications

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Cardiac patches, typically made from non‐conductive polymers, are a promising treatment for myocardial infarction (MI). Introducing electroconductive fibres in these patches improves clinical outcomes, but current production methods limited. This study aims to design and manufacture polymeric cardiac scaffolds that closely match native tissue, using pressurised gyration (PG) conductive polymers (CP). In this study, the first time, polypyrrole (PPy) with polycaprolactone (PCL) chloroform Poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS) polyethylene oxide (PEO) water, pressure spun varying CP concentrations (5–10% w/v) applied pressures (0–0.2 MPa). SEM shows resemble thickness uniformity of natural fibres, as PEDOT:PSS 5%, 0 MPa matched endomysium, 10%, aligned perimysium, PPy 7.5%, mimicked epimysium diameters 0.38, 1.02, 3.88 µm, respectively. Four‐point probe testing reveals closest electrical conductivity measurement reported chambers values is 0.22 S m −1 , achieved by 0.2MPa. FTIR verified absence residual solvent, confirming due polymer bonds. The confirms produced have ideal physicochemical properties tissue engineering, demonstrating PG's potential scalable technique manufacturing, advancing patch development MI treatment.

Language: Английский

The tailored manufacturing of core (cellulose acetate)-sheath (polyvinylpyrrolidone) polymeric nanofibers for biphasic drug delivery systems using pressure-spinning

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113939 - 113939

Published: April 1, 2025

Language: Английский