Understanding and targeting resistance mechanisms in cancer

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: May 22, 2023

Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes treatment failure and poor patient survival. The reduced responsiveness cells multifaceted that can arise from genetic, epigenetic, microenvironmental factors. Various mechanisms have discovered extensively studied, including drug inactivation, intracellular accumulation by uptake or increased efflux, target alteration, activation compensatory pathways for cell survival, regulation DNA repair death, tumor plasticity, microenvironments (TMEs). To overcome resistance, variety strategies proposed, are designed enhance effectiveness reduce resistance. These include identifying biomarkers predict response new targets, developing targeted drugs, combination targeting multiple signaling pathways, modulating TME. present article focuses on different resistance corresponding tackling approaches with recent updates. Perspectives polytherapy mechanisms, novel nanoparticle delivery systems, advanced design tools overcoming also reviewed.

Language: Английский

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pH-Responsive Polymer Nanomaterials for Tumor Therapy

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 22, 2022

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals microenvironment, various stimuli-responsive delivery systems can be constructed sites. Among these, pH is frequently utilized, owing being lower than that blood and healthy tissues. pH-responsive polymer carriers improve efficiency in vivo , allow delivery, reduce adverse reactions, enabling multifunctional personalized treatment. polymers have gained increasing interest due their advantageous properties potential applicability therapy. In this review, recent advances in, common applications of, nanomaterials therapy are summarized, with a focus on different types polymers. Moreover, future field prospected.

Language: Английский

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Smart transformable nanoparticles for enhanced tumor theranostics

Applied Physics Reviews, Journal Year: 2021, Volume and Issue: 8(4)

Published: Dec. 1, 2021

The physical morphologies of nanoparticles, especially size and shape, always significantly influence their biological behaviors. In the past, nanoparticles with constant have been widely investigated applied in tumor theranostics. With increased in-depth knowledge tumors physiological microenvironments, are required to self-adjust during circulation varying microenvironments when reaching site that possess distinct microenvironments. Therefore, smart transformable nanomaterials, which can alter under different conditions, show great potential advanced This review summarizes nanoparticles' on behaviors highlights designs serving as a guideline for construction, intensively discusses recent biomedical applications these theranostics, also proposes future challenges perspectives development

Language: Английский

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Information Storage Based on Stimuli‐Responsive Fluorescent 3D Code Materials

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(20)

Published: Feb. 18, 2022

Abstract With the booming of information technology, considerable progress has been witnessed in storage carriers, accompanied by soaring capacity. 3D codes as an emerging carrier attracted wide attention. However, it is challenging for conventional to transform their encoded information, restricting applications. Due rich color characteristics and various stimuli responsiveness, fluorescent materials can be utilized construct stimuli‐responsive code systems that exhibit pattern changes upon specific external stimuli, thereby realizing transformation. According type several kinds are classified summarized, including pH ion light electricity time some separate multiple responsiveness. This review summarizes recent systems, elaborates on how they realize transformation, analyzes potential applications, puts forward perspectives further development this field. The authors anticipate provide guidelines design novel promote science technology.

Language: Английский

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Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

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