Luminescent Ultrashort Peptide Hydrogelator with Enhanced Photophysical Implications and Biocompatibility

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel ultra-short peptide hydrogelator capable of exhibiting excellent aggregation-induced emission and biocompatible features that have been exploited for in vitro cellular imaging.

Language: Английский

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12-Hydroxy-Lauric Acid Tethered Self-Assembled Heterochiral Diphenylalanine-Based Mechanoresponsive and Proteolytically Stable Hydrogel: A Dual Player for Handling Cancer and Bacterial Challenges

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Deciphering the most promising strategy for evolution of cancer patient management remains a multifaceted, challenging affair to date. Additionally, such approaches often lead microbial infections as side effects, probably due compromised immunity patients undergoing treatment. Distinctly, this work delineates rational combinatorial harnessing stereogenic harmony in diphenylalanine fragment, tethering it an amphiphile 12-hydroxy-lauric acid at N-terminus (compounds I-III) that potential therapeutic could be extracted out from series. Aligned goal, cytotoxic properties and cell viability compounds were investigated using two distinct lines: MCF-7 (human breast cell) HEK 293 embryonic kidney). Our rigorous investigations revealed I-III exhibited substantial impact on MCF7 line. But pool three constructs, compound III (12-hydroxy-lauric -d-Phe-l-Phe-OH) showed better selectivity toward cancerous over normal comparison others, backed by computational calculations. Henceforth, was fished series used its elaborate anticancer activities reactive oxygen species generation, DNA fragmentation, caspase-dependent gene expression employing extrinsic intrinsic apoptotic factors well inflammatory biomarkers, namely, TNF-α IL1-β. We anticipated III, possessing mechanoresponsiveness nanofibrillar network, administered with injections because shear-thinning properties. Moreover, optimum partition coefficient might have allowed scaffold penetrate cellular membranes form dilactate complex (compound VI) when exposed accumulated lactates/lactic acids, common phenomenon observed within hypoxic tumor cores, accordance Warburg mechanism, thereby evading cytotoxicity cells. Besides, supramolecular β-sheets manifest antimicrobial efficacy against pathogens, Gram-positive bacteria, S. aureus B. subtilis, Gram-negative E. coli P. aeruginosa, fungus, C. albicans, along proteolytic stability high mechanical strength physiological pH. Overall, we speculate discovery these multifunctional bioinspired materials holds future promise preferential therapeutics remediation immune-susceptible patients, afflicted arising alone or effects chemotherapeutic medications.

Language: Английский

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Fmoc-conjugated dipeptides-based hydrogels and their pH-tuneable behaviour

Soft Matter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Fmoc-dipeptide-based thixotropic, injectable, and biocompatible hydrogels were developed. Hydrogel properties highly dependent on the pH of solution.

Language: Английский

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Synthesis of d-glucono-1,4-lactones modified with linear saturated fatty acids as novel low molecular-weight organogelators and evaluation of their physical properties

Soft Matter, Journal Year: 2025, Volume and Issue: 21(10), P. 1970 - 1983

Published: Jan. 1, 2025

To develop a novel low molecular-weight organogelator, D-glucono-1,4-lactones were synthesized with all hydroxy groups esterified linear saturated fatty acids, and their gelation ability was evaluated. When acid introduced, the six-membered ring D-glucono-1,5-lactone transformed into five-membered D-glucono-1,4-lactone, regardless of length acid. However, depended on acid, compounds palmitic (16 carbons) stearic (18 showed better ability. Electron microscopy that structure xerogels varied acids. Some formed fibrous structures others plate-like crystals, building up to porous structure. In addition physical properties as an emulsification crystal polymorphism confirmed, detailed polymorphic analysis through FT-IR performed estimate intermolecular packing at molecular level.

Language: Английский

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Supramolecular Hydrogels Derived from 2:1-[α/aza]-Pseudopeptides: Design, Structural Analysis and Self-Assembly in Solution, Solid, and Gel States

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Structural determination of the weak interactions gives clues, at atomic scale, to design and formulate new innovating supramolecular hydrogels based on low molecular weight gelators (LMWGs < 2000 Da).

Language: Английский

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Self-Assembling Peptide Hydrogels: Design, Mechanisms, Characterization, and Biomedical Applications

Soft Matter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Structural characteristics, molecular driving forces, and medical applications of multifunctional peptide-based biomaterial hydrogels.

Language: Английский

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自组装纳米抗菌肽的设计策略及应用

Chinese Science Bulletin (Chinese Version), Journal Year: 2024, Volume and Issue: 69(28-29), P. 4267 - 4280

Published: July 26, 2024

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