Multi-omics approaches to disease

Genome biology, Journal Year: 2017, Volume and Issue: 18(1)

Published: May 5, 2017

High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field "integrative genetics". Other omics technologies, such as proteomics metabolomics, are now often incorporated into everyday methodology biological researchers. In this review, we provide an overview focus on their integration across multiple layers. As compared a single type, multi-omics offers opportunity understand flow information that underlies disease.

Language: Английский

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A Novel Integrated Method for Large-Scale Detection, Identification, and Quantification of Widely Targeted Metabolites: Application in the Study of Rice Metabolomics

Molecular Plant, Journal Year: 2013, Volume and Issue: 6(6), P. 1769 - 1780

Published: May 24, 2013

Language: Английский

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Multivariate Analysis in Metabolomics

Current Metabolomics, Journal Year: 2012, Volume and Issue: 1(1), P. 92 - 107

Published: Nov. 1, 2012

Metabolomics aims to provide a global snapshot of all small-molecule metabolites in cells and biological fluids, free observational biases inherent more focused studies metabolism. However, the staggeringly high information content such analyses introduces challenge its own; efficiently forming biologically relevant conclusions from any given metabolomics dataset indeed requires specialized forms data analysis. One approach finding meaning datasets involves multivariate analysis (MVA) methods as principal component (PCA) partial least squares projection latent structures (PLS), where spectral features contributing most variation or separation are identified for further with mathematical treatment, these not panacea; this review discusses use metabolomics, well common pitfalls misconceptions.

Language: Английский

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mRNAs, proteins and the emerging principles of gene expression control

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 21(10), P. 630 - 644

Published: July 24, 2020

Language: Английский

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Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

Chemical Society Reviews, Journal Year: 2010, Volume and Issue: 40(1), P. 387 - 426

Published: Aug. 17, 2010

The study of biological systems in a holistic manner (systems biology) is increasingly being viewed as necessity to provide qualitative and quantitative descriptions the emergent properties complete system. Systems biology performs studies focussed on complex interactions system components; emphasising whole rather than individual parts. Many perturbations mammalian (diet, disease, drugs) are multi-factorial small parts insufficient understand phenotypic changes induced. Metabolomics one functional level tool employed investigate metabolites with other (metabolism) but also regulatory role through interaction genes, transcripts proteins (e.g. allosteric regulation). Technological developments driving force behind advances scientific knowledge. Recent two analytical platforms mass spectrometry (MS) nuclear magnetic resonance (NMR) spectroscopy have driven forward discipline metabolomics. In this critical review, an introduction metabolites, metabolomes, metabolomics MS NMR will be provided. applications for health-disease continuum, drug efficacy toxicity dietary effects health reviewed. current limitations future goals discussed (374 references).

Language: Английский

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Clinical Applications of Metabolomics in Oncology: A Review

Clinical Cancer Research, Journal Year: 2009, Volume and Issue: 15(2), P. 431 - 440

Published: Jan. 15, 2009

Abstract Metabolomics, an omic science in systems biology, is the global quantitative assessment of endogenous metabolites within a biological system. Either individually or grouped as metabolomic profile, detection carried out cells, tissues, biofluids by either nuclear magnetic resonance spectroscopy mass spectrometry. There potential for metabolome to have multitude uses oncology, including early and diagnosis cancer both predictive pharmacodynamic marker drug effect. Despite this, there lack knowledge oncology community regarding metabolomics confusion about its methodologic processes, technical challenges, clinical applications. when used translational research tool, can provide link between laboratory clinic, particularly because metabolic molecular imaging technologies, such positron emission tomography spectroscopic imaging, enable discrimination markers noninvasively vivo. Here, we review current applications metabolomics, focusing on use biomarker diagnosis, prognosis, therapeutic evaluation.

Language: Английский

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Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Nature Methods, Journal Year: 2021, Volume and Issue: 18(7), P. 747 - 756

Published: July 1, 2021

Language: Английский

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Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics

Analytical Chemistry, Journal Year: 2015, Volume and Issue: 88(1), P. 524 - 545

Published: Dec. 4, 2015

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTToward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics LipidomicsTomas Cajka† Oliver Fiehn*†‡View Author Information† UC Davis Genome Center−Metabolomics, University of California Davis, 451 Health Sciences Drive, 95616, United States‡ King Abdulaziz University, Faculty Science, Biochemistry Department, P.O. Box 80203, Jeddah 21589, Saudi Arabia*Phone: +1-530-754-8258. Fax: +1-530-754-9658. E-mail: [email protected]Cite this: Anal. Chem. 2016, 88, 1, 524–545Publication Date (Web):December 4, 2015Publication History Published online16 December 2015Published inissue 5 January 2016https://pubs.acs.org/doi/10.1021/acs.analchem.5b04491https://doi.org/10.1021/acs.analchem.5b04491review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views20448Altmetric-Citations571LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ions,Lipidomics,Lipids,Metabolism,Metabolomics Get e-Alerts

Language: Английский

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Metabolomics for Functional Genomics, Systems Biology, and Biotechnology

Annual Review of Plant Biology, Journal Year: 2009, Volume and Issue: 61(1), P. 463 - 489

Published: Jan. 23, 2009

Metabolomics now plays a significant role in fundamental plant biology and applied biotechnology. Plants collectively produce huge array of chemicals, far more than are produced by most other organisms; hence, metabolomics is great importance biology. Although substantial improvements have been made the field metabolomics, uniform annotation metabolite signals databases informatics through international standardization efforts remains challenge, as does development new fields such fluxome analysis single cell analysis. The principle transcript cooccurrence, particularly transcriptome coexpression network analysis, powerful tool for decoding function genes Arabidopsis thaliana. This strategy can be used identification involved specific pathways crops medicinal plants. has gained biotechnology applications, exemplified quantitative loci prediction food quality, evaluation genetically modified crops. Systems driven metabolome data will aid deciphering secrets systems their application to

Language: Английский

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The Molecular Identification of Organic Compounds in the Atmosphere: State of the Art and Challenges

Chemical Reviews, Journal Year: 2015, Volume and Issue: 115(10), P. 3919 - 3983

Published: Feb. 3, 2015

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTThe Molecular Identification of Organic Compounds in the Atmosphere: State Art and ChallengesBarbara Nozière*†, Markus Kalberer*‡, Magda Claeys*§, James Allan∥, Barbara D'Anna†, Stefano Decesari⊥, Emanuela Finessi#, Marianne Glasius∇, Irena Grgić○, Jacqueline F. Hamilton#, Thorsten Hoffmann◆, Yoshiteru Iinuma¶, Mohammed Jaoui△, Ariane Kahnt§, Christopher J. Kampf▲, Ivan Kourtchev‡, Willy Maenhaut§□, Nicholas Marsden∥, Sanna Saarikoski■, Jürgen Schnelle-Kreis◇, Jason D. Surratt▼, Sönke Szidat☆, Rafal Szmigielski★, Armin Wisthaler⬡View Author Information† Ircelyon/CNRS Université Lyon 1, 69626 Villeurbanne Cedex, France‡ University Cambridge, Cambridge CB2 1EW, United Kingdom§ Antwerp, 2000 Belgium∥ The Manchester & National Centre for Atmospheric Science, M13 9PL, Kingdom⊥ Istituto ISAC - C.N.R., I-40129 Bologna, Italy# York, York YO10 5DD, Kingdom∇ Aarhus, 8000 Aarhus C, Denmark○ Institute Chemistry, 1000 Ljubljana, Slovenia◆ Johannes Gutenberg-Universität, 55122 Mainz, Germany¶ Leibniz-Institut für Troposphärenforschung, 04318 Leipzig, Germany△ Alion Science Technology, McLean, Virginia 22102, States▲ Max Planck 55128 Germany□ Ghent University, 9000 Gent, Belgium■ Finnish Meteorological Institute, FI-00101 Helsinki, Finland◇ Helmholtz Zentrum München, D-85764 Neuherberg, Germany▼ North Carolina at Chapel Hill, 27599, States☆ Bern, 3012 Switzerland★ Physical Chemistry PAS, Warsaw 01-224, Poland⬡ Oslo, 0316 Norway*E-mail: [email protected]*E-mail: protected]Cite this: Chem. Rev. 2015, 115, 10, 3919–3983Publication Date (Web):February 3, 2015Publication History Received1 July 2014Published online3 February 2015Published inissue 27 May 2015https://pubs.acs.org/doi/10.1021/cr5003485https://doi.org/10.1021/cr5003485review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views12686Altmetric-Citations384LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aerosols,Chromatography,Mathematical methods,Organic compounds,Redox reactions Get e-Alerts

Language: Английский

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