Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation DOI Creative Commons
Sirikwan Sangboonruang, Natthawat Semakul,

Kiattikhun Manokruang

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100291 - 100291

Published: Oct. 11, 2024

Chronic wound infections are attributed to delayed tissue repair, which remains a major clinical challenge in long-term health care. Particularly, with antibiotic resistance have more serious effects on health, often resulting unsuccessful treatments. Thus, antimicrobial peptide (AMP)-based therapy holds promise as potential therapeutic approach overcoming drug resistance. Conventional dressing is passive strategy for care that not capable of eradicating pathogens and promoting repair. In this study, we aim construct an advanced dressing; thermo-responsive hydrogel incorporated lactoferricin (Lfcin) niosome (Lfcin-Nio/hydrogel) bacterial pathogen treatment. The Lfcin-loaded (Lfcin-Nio) has particle size 396.91 ± 20.96 nm, 0.38 0.01 PdI, -10.5 0.3 mV ζ potential, 72.30 7.05 % Lfcin entrapment efficiency. Lfcin-Nio exhibited broad antibacterial activity both drug-susceptible drug-resistant strains, also bacteria residing the biofilm matrix. Lfcin-Nio/hydrogel was fabricated from 0.5

Language: Английский

Hydrogels and Wound Healing: Current and Future Prospects DOI Creative Commons

Varshan Gounden,

Moganavelli Singh

Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 43 - 43

Published: Jan. 5, 2024

The care and rehabilitation of acute chronic wounds have a significant social economic impact on patients global health. This burden is primarily due to the adverse effects infections, prolonged recovery, associated treatment costs. Chronic can be treated with variety approaches, which include surgery, negative pressure wound therapy, dressings, hyperbaric oxygen therapy. However, each these strategies has an array limitations. existing dry dressings lack functionality in promoting healing exacerbating pain by adhering wound. Hydrogels, are commonly polymer-based swell water, been proposed as potential remedies their ability provide moist environment that facilitates healing. Their unique composition enables them absorb exudates, exhibit shape adaptability, modified incorporate active compounds such growth factors antibacterial compounds. review provides updated discussion leading natural synthetic hydrogels utilized healing, details latest advancements hydrogel technology, explores alternate approaches this field. Search engines Scopus, PubMed, Science Direct, Web were advances applications over last fifteen years.

Language: Английский

Citations

80
STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS DOI Creative Commons

Mohammad Qutub,

Amol Tatode, Jayshree Taksande

et al.

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

Citations

6
A hybrid machine learning framework for predicting drug-release profiles, kinetics, and mechanisms of temperature-responsive hydrogels DOI
Maha Mohammad AL-Rajabi,

Samer Alzyod,

Akshay Patel

et al.

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

2
4D Bioprinting: Keeping the Technology Alive DOI Creative Commons
Patrick Imrie, Jianyong Jin

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract 4D bioprinting is a groundbreaking technology with potential to revolutionize healthcare. It based on additive manufacturing technologies, which are used fabricate dynamic prosthetics and devices from biologically compatible smart materials that respond stimuli. The ultimate end of the creation an artificial organ perfectly mimics functional movements native fully integrated within human body. In this perspective, two phases identified toward end. first minimally invasive surgery (MIS) using shape memory composites stimulated by near‐infrared (NIR) light and/or magnetic fields. second tissue engineering (DTE) activation biological

Language: Английский

Citations

2
Wearable hydrogel-based health monitoring systems: A new paradigm for health monitoring? DOI

Xintao Wang,

Haixia Ji,

Li Gao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153382 - 153382

Published: June 21, 2024

Language: Английский

Citations

10
Stimuli-Responsive Hydrogels Potentiating Photothermal Therapy against Cancer Stem Cell–Induced Breast Cancer Metastasis DOI
Tianfu Zhang, Ping Wei,

Meng Suo

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20313 - 20323

Published: July 24, 2024

The self-renewal and differentiation properties of cancer stem cells (CSCs) result in chemoresistance breast cancer. Even though numerous drugs have been developed to target CSCs, they suffered from inefficient delivery accumulation at the focal site. Here, a thermoresponsive hydrogel is by coencapsulating aggregation-induced emission (AIE)-active photothermal agent thioridazine (THZ), demonstrating controllable system triggered AIE augment THZ-mediated CSC ablation. Upon near-infrared laser stimuli, effect induces deformation for burst drug release. precise situ tumor administration accelerates diffusion deep lesions. Thus, THZ can invade tumors provoke massive apoptosis via dopamine receptor blockage oxidative stress induction. Consequently, effective inhibition significant suppression recurrence metastasis are demonstrated mice with We believe that this intelligent hydrogel-based represents promising treatment strategy metastatic clinical potential.

Language: Английский

Citations

9
Development and Evaluation of Thermosensitive Hydrogels for Hydrogen Sulfide Gas Release: A Novel Approach for Therapeutic Applications DOI Open Access
Hai Thanh Phan,

Huyen Thanh Anh Nguyen,

Luan Minh Nguyen

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

ABSTRACT Hydrogen sulfide (H₂S) plays a critical role in regulating various pathological processes, such as protecting cells from injury and promoting tissue regeneration, making it focus of therapeutic applications. However, the unpredictable release H₂S donors limit its clinical use. In this study, novel delivery system was developed by encapsulating 5‐aminopyridine‐2‐thiocarboxamide (APTC), small‐molecule donor, into gelatin‐Pluronic (GP) thermosensitive hydrogel. The GP hydrogel exhibited excellent thermosensitivity, transitioning sol to gel at physiological temperature (~37°C) while maintaining gelling upon APTC addition, ideal for minimally invasive methylene blue assay demonstrated controlled release, with highest cumulative (1.2 mM) 80 h GP‐APTC 15 Cytocompatibility cell behavior studies using HUVECs showed that significantly enhanced migration, fully covering scratched areas within 24 h. hydrogels also promoted angiogenesis, evidenced vitro tube formation ovo CAM assays, greater concentrations leading increased branching denser vascular networks. This study highlights novelty platform, offering significant potential applications, including regeneration wound healing.

Language: Английский

Citations

1
Advances in pharmaceutical and biomedical applications of plant–based nano-biopolymers with special emphasis on vaginal drug delivery systems: A review DOI Creative Commons

Rafia Noor-ul-Ain,

Noshin Ilyas,

Maimona Saeed

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 225, P. 120592 - 120592

Published: Jan. 25, 2025

Language: Английский

Citations

1
Regenerative medicine: Hydrogels and mesoporous silica nanoparticles DOI Creative Commons
Jesús L. Pablos, Daniel Lozano, Miguel Manzano

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101342 - 101342

Published: Nov. 14, 2024

Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility biodegradability, closely resemble living tissues. The versatility hydrogels has fuelled application in various fields, agriculture, biomaterials, the food industry, drug delivery, tissue engineering, regenerative medicine. combination nanoparticles, specifically Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to next level, since MSNs could improve hydrogel mechanical ability encapsulate controlled release great amounts different therapeutic agents, responsiveness a variety external internal stimuli. In this review, main features both introduced, followed by discussion hydrogels-MSNs structures an overview use applications, delivery technologies engineering.

Language: Английский

Citations

4
A hydrogel miscible azelaic acid‐ionic liquids for the treatment of acne vulgaris: Enhanced solubility and skin retention DOI Creative Commons
Zhezheng Fang,

Xianzi Zheng,

Yanyun Ma

et al.

MedComm – Biomaterials and Applications, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 2, 2025

Abstract Azelaic acid (AzA) is a natural dicarboxylic used to treat acne vulgaris but greatly limited by poor aqueous solubility. This study aims enhance the solubility and skin retention of AzA ionic liquids (ILs). AzA‐ILs were synthesized decomposition reaction with amine compounds. Tris‐(hydroxymethyl)‐aminomethane ([AzA][Tris]) meglumine ([AzA][Meg]) at molar ratio 1:2 liquid room temperature miscible water. 1 H‐NMR FT‐IR confirmed synthesis AzA‐ILs. [AzA][Tris] got higher transdermal transport than [AzA][Meg]. ZEN has lower viscosity better spreadability Carbomer thus was adopted as gel matrix. also matrix any concentration. Hydrogels containing 10% (w/w) exhibited highest among hydrogels or concentrations AzA. AzA‐IL hydrogel (10%, w/w) obtained similar therapeutic efficacy irritation Finacea® (a marketed 15% AzA). In conclusion, ILs enhanced develop transparent achieve good treatment for vulgaris.

Language: Английский

Citations

0